Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report
The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have no...
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ftdoajarticles:oai:doaj.org/article:9224a152b48344188995e7a635cf79b4 2023-05-15T15:11:10+02:00 Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report Nhora Silva Natalia Calvache Elizabeth Arrieta Juan Carlos Bravo Camilo Salazar Joaquín Rosales Francisco Jaramillo Juan Guillermo Restrepo 2018-09-01T00:00:00Z https://doi.org/10.7705/biomedica.v38i3.3739 https://doaj.org/article/9224a152b48344188995e7a635cf79b4 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3739 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i3.3739 https://doaj.org/article/9224a152b48344188995e7a635cf79b4 Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 3, Pp 298-302 (2018) Histoplasma histoplasmosis leucemia linfocítica crónica de células B linfoma no Hodgkin granuloma informes de casos Medicine R Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.7705/biomedica.v38i3.3739 2022-12-30T21:16:28Z The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. A female 82-year-old patient was admitted due to an intermittent dry cough, asthenia, and adynamia that had persisted for one month. Multiple studies to detect infections and immuno-rheumatic conditions were performed and an extensive cervical, thoracic and peritoneal adenopathic syndrome was diagnosed. A flow cytometry and a cervical lymph node biopsy were performed reporting CD19+, CD20dim, CD5+, CD45+, CD23+, CD43neg, and CD10neg phenotypes with restriction in the light kappa chain compatible with a small lymphocytic lymphoma. Epithelioid granulomas without necrosis were observed in the lymph node histopathology and special colorations showed no microorganisms. The culture from the lymph node was positive for Histoplasma capsulatum. We initiated treatment with amphotericin B and itraconazole with an adequate response. In the absence of compliance with oncology treatment criteria, the patient was managed on a “watch and wait” basis. Opportunistic infections could be the initial clinical manifestation in patients with low-grade lymphoproliferative syndromes. This case report shows that they can develop even in the absence of chemotherapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 38 3 298 302 |
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language |
English Spanish |
topic |
Histoplasma histoplasmosis leucemia linfocítica crónica de células B linfoma no Hodgkin granuloma informes de casos Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Histoplasma histoplasmosis leucemia linfocítica crónica de células B linfoma no Hodgkin granuloma informes de casos Medicine R Arctic medicine. Tropical medicine RC955-962 Nhora Silva Natalia Calvache Elizabeth Arrieta Juan Carlos Bravo Camilo Salazar Joaquín Rosales Francisco Jaramillo Juan Guillermo Restrepo Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
topic_facet |
Histoplasma histoplasmosis leucemia linfocítica crónica de células B linfoma no Hodgkin granuloma informes de casos Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. A female 82-year-old patient was admitted due to an intermittent dry cough, asthenia, and adynamia that had persisted for one month. Multiple studies to detect infections and immuno-rheumatic conditions were performed and an extensive cervical, thoracic and peritoneal adenopathic syndrome was diagnosed. A flow cytometry and a cervical lymph node biopsy were performed reporting CD19+, CD20dim, CD5+, CD45+, CD23+, CD43neg, and CD10neg phenotypes with restriction in the light kappa chain compatible with a small lymphocytic lymphoma. Epithelioid granulomas without necrosis were observed in the lymph node histopathology and special colorations showed no microorganisms. The culture from the lymph node was positive for Histoplasma capsulatum. We initiated treatment with amphotericin B and itraconazole with an adequate response. In the absence of compliance with oncology treatment criteria, the patient was managed on a “watch and wait” basis. Opportunistic infections could be the initial clinical manifestation in patients with low-grade lymphoproliferative syndromes. This case report shows that they can develop even in the absence of chemotherapy. |
format |
Article in Journal/Newspaper |
author |
Nhora Silva Natalia Calvache Elizabeth Arrieta Juan Carlos Bravo Camilo Salazar Joaquín Rosales Francisco Jaramillo Juan Guillermo Restrepo |
author_facet |
Nhora Silva Natalia Calvache Elizabeth Arrieta Juan Carlos Bravo Camilo Salazar Joaquín Rosales Francisco Jaramillo Juan Guillermo Restrepo |
author_sort |
Nhora Silva |
title |
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
title_short |
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
title_full |
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
title_fullStr |
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
title_full_unstemmed |
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report |
title_sort |
disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: a case report |
publisher |
Instituto Nacional de Salud |
publishDate |
2018 |
url |
https://doi.org/10.7705/biomedica.v38i3.3739 https://doaj.org/article/9224a152b48344188995e7a635cf79b4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 3, Pp 298-302 (2018) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3739 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i3.3739 https://doaj.org/article/9224a152b48344188995e7a635cf79b4 |
op_doi |
https://doi.org/10.7705/biomedica.v38i3.3739 |
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Biomédica |
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38 |
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3 |
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298 |
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302 |
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