Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study
Background: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagi...
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ftdoajarticles:oai:doaj.org/article:91f13261b8ab42459d9c855572198187 2023-05-15T17:45:00+02:00 Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study Kristina Johansson Jan-Håkan Jansson Lars Johansson Ingemar Bylesjö Torbjörn K. Nilsson Mats Eliasson Stefan Söderberg Marcus Lind 2017-04-01T00:00:00Z https://doi.org/10.1159/000468994 https://doaj.org/article/91f13261b8ab42459d9c855572198187 EN eng Karger Publishers http://www.karger.com/Article/FullText/468994 https://doaj.org/toc/1664-5456 1664-5456 doi:10.1159/000468994 https://doaj.org/article/91f13261b8ab42459d9c855572198187 Cerebrovascular Diseases Extra, Vol 7, Iss 1, Pp 84-94 (2017) Coagulation Biomarkers Intracranial hemorrhage Cohort study Cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701 article 2017 ftdoajarticles https://doi.org/10.1159/000468994 2022-12-31T05:28:11Z Background: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagic stroke. The aim of this study was to investigate the correlation between FXII and cardiovascular risk factors in the general population. We also aimed to study the associations between FXII levels and future myocardial infarction and ischemic and hemorrhagic stroke. Methods: This prospective cohort study measured FXII levels in 1,852 randomly selected participants in a health survey performed in northern Sweden in 1994. Participants were followed until myocardial infarction, stroke, death, or until December 31, 2011. Results: During the median follow-up of 17.9 years, 165 individuals were diagnosed with myocardial infarction, 108 with ischemic stroke, and 30 with hemorrhagic stroke. There were weak correlations between FXII and body mass index, cholesterol, and hypertension. There was no association between FXII and myocardial infarction or ischemic stroke, neither in univariable Cox regression analysis nor after adjustment for age, sex, smoking, body mass index, cholesterol, hypertension, and diabetes. In univariable Cox regression analysis, the hazard ratio for the association between FXII levels and hemorrhagic stroke was 1.42 per SD (95% confidence interval: 0.99–2.05). In the multivariable model, higher levels of FXII were associated with increased risk of hemorrhagic stroke (hazard ratio 1.51 per SD; 95% confidence interval: 1.03–2.21). Conclusion: We found an independent association between FXII levels and the risk of hemorrhagic stroke, but not between FXII levels and ischemic stroke or myocardial infarction. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Cerebrovascular Diseases Extra 7 1 84 94 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Coagulation Biomarkers Intracranial hemorrhage Cohort study Cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
Coagulation Biomarkers Intracranial hemorrhage Cohort study Cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701 Kristina Johansson Jan-Håkan Jansson Lars Johansson Ingemar Bylesjö Torbjörn K. Nilsson Mats Eliasson Stefan Söderberg Marcus Lind Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
topic_facet |
Coagulation Biomarkers Intracranial hemorrhage Cohort study Cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Background: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagic stroke. The aim of this study was to investigate the correlation between FXII and cardiovascular risk factors in the general population. We also aimed to study the associations between FXII levels and future myocardial infarction and ischemic and hemorrhagic stroke. Methods: This prospective cohort study measured FXII levels in 1,852 randomly selected participants in a health survey performed in northern Sweden in 1994. Participants were followed until myocardial infarction, stroke, death, or until December 31, 2011. Results: During the median follow-up of 17.9 years, 165 individuals were diagnosed with myocardial infarction, 108 with ischemic stroke, and 30 with hemorrhagic stroke. There were weak correlations between FXII and body mass index, cholesterol, and hypertension. There was no association between FXII and myocardial infarction or ischemic stroke, neither in univariable Cox regression analysis nor after adjustment for age, sex, smoking, body mass index, cholesterol, hypertension, and diabetes. In univariable Cox regression analysis, the hazard ratio for the association between FXII levels and hemorrhagic stroke was 1.42 per SD (95% confidence interval: 0.99–2.05). In the multivariable model, higher levels of FXII were associated with increased risk of hemorrhagic stroke (hazard ratio 1.51 per SD; 95% confidence interval: 1.03–2.21). Conclusion: We found an independent association between FXII levels and the risk of hemorrhagic stroke, but not between FXII levels and ischemic stroke or myocardial infarction. |
format |
Article in Journal/Newspaper |
author |
Kristina Johansson Jan-Håkan Jansson Lars Johansson Ingemar Bylesjö Torbjörn K. Nilsson Mats Eliasson Stefan Söderberg Marcus Lind |
author_facet |
Kristina Johansson Jan-Håkan Jansson Lars Johansson Ingemar Bylesjö Torbjörn K. Nilsson Mats Eliasson Stefan Söderberg Marcus Lind |
author_sort |
Kristina Johansson |
title |
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
title_short |
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
title_full |
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
title_fullStr |
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
title_full_unstemmed |
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study |
title_sort |
factor xii as a risk marker for hemorrhagic stroke: a prospective cohort study |
publisher |
Karger Publishers |
publishDate |
2017 |
url |
https://doi.org/10.1159/000468994 https://doaj.org/article/91f13261b8ab42459d9c855572198187 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Cerebrovascular Diseases Extra, Vol 7, Iss 1, Pp 84-94 (2017) |
op_relation |
http://www.karger.com/Article/FullText/468994 https://doaj.org/toc/1664-5456 1664-5456 doi:10.1159/000468994 https://doaj.org/article/91f13261b8ab42459d9c855572198187 |
op_doi |
https://doi.org/10.1159/000468994 |
container_title |
Cerebrovascular Diseases Extra |
container_volume |
7 |
container_issue |
1 |
container_start_page |
84 |
op_container_end_page |
94 |
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1766147705834307584 |