ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan
Abstract Background Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women. Aim The study aimed to investigate the role of ABO blood groups on pregnancy outcomes in an area of unstabl...
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ftdoajarticles:oai:doaj.org/article:91d6d3fb3043431a9eed84fe8edbd225 2023-05-15T15:14:47+02:00 ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M 2007-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-110 https://doaj.org/article/91d6d3fb3043431a9eed84fe8edbd225 EN eng BMC http://www.malariajournal.com/content/6/1/110 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-110 1475-2875 https://doaj.org/article/91d6d3fb3043431a9eed84fe8edbd225 Malaria Journal, Vol 6, Iss 1, p 110 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-110 2022-12-31T04:39:34Z Abstract Background Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women. Aim The study aimed to investigate the role of ABO blood groups on pregnancy outcomes in an area of unstable malaria transmission in eastern Sudan. Methods A total of 293 women delivering in New Half teaching hospital, eastern Sudan during the period October 2006–March 2007 have been analyzed. ABO blood groups were determined and placental histopathology examinations for malaria were performed. Birth and placental weight were recorded and maternal haemoglobin was measured. Results 114 (39.7%), 61 (22.1%) and 118 (38.2%) women were primiparae, secundiparae and multiparae, respectively. The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128 (O). Placental histopathology showed acute placental malaria infections in 6 (2%), chronic infections in 6 (2%), 82 (28.0%) of the placentae showed past infection and 199 (68.0%) showed no infection. There was no association between the age (OR = 1.02, 95% CI = 0.45–2.2; P = 0.9), parity (OR = 0.6, 95% CI = 0.3–1.2; P = 0.1) and placental malaria infections. In all parity blood group O was associated with a higher risk of past (OR = 1.9, 95% CI = 1.1–3.2; P = 0.01) placental malaria infection. This was also true when primiparae were considered separately (OR = 2.6, 95% CI = 1.05–6.5, P = 0.03). Among women with all placental infections/past placental infection, the mean haemoglobin was higher in women with the blood group O, but the mean birth weight, foeto-placental weight ratio was not different between these groups and the non-O group. Conclusion These results indicate that women of eastern Sudan are at risk for placental malaria infection irrespective to their age or parity. Those women with blood group O were at higher risk of past placental malaria infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women. Aim The study aimed to investigate the role of ABO blood groups on pregnancy outcomes in an area of unstable malaria transmission in eastern Sudan. Methods A total of 293 women delivering in New Half teaching hospital, eastern Sudan during the period October 2006–March 2007 have been analyzed. ABO blood groups were determined and placental histopathology examinations for malaria were performed. Birth and placental weight were recorded and maternal haemoglobin was measured. Results 114 (39.7%), 61 (22.1%) and 118 (38.2%) women were primiparae, secundiparae and multiparae, respectively. The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128 (O). Placental histopathology showed acute placental malaria infections in 6 (2%), chronic infections in 6 (2%), 82 (28.0%) of the placentae showed past infection and 199 (68.0%) showed no infection. There was no association between the age (OR = 1.02, 95% CI = 0.45–2.2; P = 0.9), parity (OR = 0.6, 95% CI = 0.3–1.2; P = 0.1) and placental malaria infections. In all parity blood group O was associated with a higher risk of past (OR = 1.9, 95% CI = 1.1–3.2; P = 0.01) placental malaria infection. This was also true when primiparae were considered separately (OR = 2.6, 95% CI = 1.05–6.5, P = 0.03). Among women with all placental infections/past placental infection, the mean haemoglobin was higher in women with the blood group O, but the mean birth weight, foeto-placental weight ratio was not different between these groups and the non-O group. Conclusion These results indicate that women of eastern Sudan are at risk for placental malaria infection irrespective to their age or parity. Those women with blood group O were at higher risk of past placental malaria infection. |
format |
Article in Journal/Newspaper |
author |
Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M |
author_facet |
Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M |
author_sort |
Prins Martin H |
title |
ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
title_short |
ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
title_full |
ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
title_fullStr |
ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
title_full_unstemmed |
ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
title_sort |
abo blood group system and placental malaria in an area of unstable malaria transmission in eastern sudan |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-110 https://doaj.org/article/91d6d3fb3043431a9eed84fe8edbd225 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 110 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/110 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-110 1475-2875 https://doaj.org/article/91d6d3fb3043431a9eed84fe8edbd225 |
op_doi |
https://doi.org/10.1186/1475-2875-6-110 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
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1766345192115273728 |