Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin
This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The...
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ftdoajarticles:oai:doaj.org/article:9165ae23a6f54caa97f7e6617972b35b 2023-05-15T15:50:46+02:00 Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová 2021-05-01T00:00:00Z https://doi.org/10.3390/genes12060832 https://doaj.org/article/9165ae23a6f54caa97f7e6617972b35b EN eng MDPI AG https://www.mdpi.com/2073-4425/12/6/832 https://doaj.org/toc/2073-4425 doi:10.3390/genes12060832 2073-4425 https://doaj.org/article/9165ae23a6f54caa97f7e6617972b35b Genes, Vol 12, Iss 832, p 832 (2021) behaviour dogs genomic diversity morphological traits protein-coding genes selection events Genetics QH426-470 article 2021 ftdoajarticles https://doi.org/10.3390/genes12060832 2022-12-31T10:47:29Z This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The dataset consisted of 131 animals and 143,593 single nucleotide polymorphisms (SNPs). The effects of demographic history on the overall genome structure were determined by screening the distribution of the homozygous segments. The genetic variance distributed within and between groups was quantified by genetic distances, the F ST index, and discriminant analysis of principal components. Fine-scale population stratification due to specific morphological and behavioural traits was assessed by principal component and factorial analyses. In the CWD, a demographic history effect was manifested mainly in a high genome-wide proportion of short homozygous segments corresponding to a historical load of inbreeding derived from founders. The observed proportion of long homozygous segments indicated that the inbreeding events shaped the CWD genome relatively recently compared to other groups. Even if there was a significant increase in genetic similarity among wolf-like breeds, they were genetically separated from each other. Moreover, this study showed that the CWD genome carries private alleles that are not found in either wolves or other dog breeds analysed in this study. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Genes 12 6 832 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
behaviour dogs genomic diversity morphological traits protein-coding genes selection events Genetics QH426-470 |
spellingShingle |
behaviour dogs genomic diversity morphological traits protein-coding genes selection events Genetics QH426-470 Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
topic_facet |
behaviour dogs genomic diversity morphological traits protein-coding genes selection events Genetics QH426-470 |
description |
This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The dataset consisted of 131 animals and 143,593 single nucleotide polymorphisms (SNPs). The effects of demographic history on the overall genome structure were determined by screening the distribution of the homozygous segments. The genetic variance distributed within and between groups was quantified by genetic distances, the F ST index, and discriminant analysis of principal components. Fine-scale population stratification due to specific morphological and behavioural traits was assessed by principal component and factorial analyses. In the CWD, a demographic history effect was manifested mainly in a high genome-wide proportion of short homozygous segments corresponding to a historical load of inbreeding derived from founders. The observed proportion of long homozygous segments indicated that the inbreeding events shaped the CWD genome relatively recently compared to other groups. Even if there was a significant increase in genetic similarity among wolf-like breeds, they were genetically separated from each other. Moreover, this study showed that the CWD genome carries private alleles that are not found in either wolves or other dog breeds analysed in this study. |
format |
Article in Journal/Newspaper |
author |
Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová |
author_facet |
Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová |
author_sort |
Nina Moravčíková |
title |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
title_short |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
title_full |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
title_fullStr |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
title_full_unstemmed |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus , German Shepherd Dog, and Different Sheepdogs of European Origin |
title_sort |
czechoslovakian wolfdog genomic divergence from its ancestors canis lupus , german shepherd dog, and different sheepdogs of european origin |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/genes12060832 https://doaj.org/article/9165ae23a6f54caa97f7e6617972b35b |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Genes, Vol 12, Iss 832, p 832 (2021) |
op_relation |
https://www.mdpi.com/2073-4425/12/6/832 https://doaj.org/toc/2073-4425 doi:10.3390/genes12060832 2073-4425 https://doaj.org/article/9165ae23a6f54caa97f7e6617972b35b |
op_doi |
https://doi.org/10.3390/genes12060832 |
container_title |
Genes |
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12 |
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6 |
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832 |
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1766385783471603712 |