Cyclophosphamide effect on coccidioidomycosis in the rat Efecto de la ciclofosfamida en la infección por Coccidioides immitis en la rata

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Mirta C. Remesar, Jorgelina L. Blejer, Ricardo Negroni, Marta R. Nejamkis
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1989
• Subjects: Cyclophosphamide; Coccidioidomycosis; Immunosuppression; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Acosta; Arctic; Droga; Rata
• Online Access: https://doi.org/10.1590/S0036-46651989000600009; https://doaj.org/article/91010b2f476a47d8a92218cb96cc5977

Coccidioidomycosis is a systemic mycosis, endemic in arid areas of the American continent. The rat was employed as an experimental host, since it had been shown to reproduce human lesions and present a chronic course of disease with granulomas mainly restricted to lungs. Given the influence of immun...