PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION
Clinical observations were made of mice in the acute stage of infection produced by three Trypanosoma cruzi strains. Mice infected with Dm74 suffered complete paralysis of the rear limbs followed by death, while still in the acute stage of Chagas' disease. Hystological analysis of skeletal musc...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2000
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ftdoajarticles:oai:doaj.org/article:90ca6f18d03a4ae7a0a9171c66e62d1f 2023-10-01T03:53:56+02:00 PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION A Lugo de Yarbuh C Colasante 2000-03-01T00:00:00Z https://doaj.org/article/90ca6f18d03a4ae7a0a9171c66e62d1f EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://produccioncientificaluz.org/index.php/kasmera/article/view/4672 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/90ca6f18d03a4ae7a0a9171c66e62d1f Kasmera, Vol 28, Iss 3 (2000) Enfermedad de Chagas músculo esquelético fibra nerviosa placa motora Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2000 ftdoajarticles 2023-09-03T00:34:23Z Clinical observations were made of mice in the acute stage of infection produced by three Trypanosoma cruzi strains. Mice infected with Dm74 suffered complete paralysis of the rear limbs followed by death, while still in the acute stage of Chagas' disease. Hystological analysis of skeletal muscle showed intense inflammatory infiltrates of mononuclear and polymorphonuclear leukocytes, fibroblasts, free red blood cells and IgG deposits in the interstilium of Gastrocnemius (G). Local miofibrillic disintegration and changes in microvessels, nerve fibers and the neuromuscular junction of G were also observed. These results indicate that the acute infection with T. cruzi may cause progressive damage in parasite infected muscle fiber and lead to loss of mobility. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Spanish |
topic |
Enfermedad de Chagas músculo esquelético fibra nerviosa placa motora Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Enfermedad de Chagas músculo esquelético fibra nerviosa placa motora Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 A Lugo de Yarbuh C Colasante PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
topic_facet |
Enfermedad de Chagas músculo esquelético fibra nerviosa placa motora Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Clinical observations were made of mice in the acute stage of infection produced by three Trypanosoma cruzi strains. Mice infected with Dm74 suffered complete paralysis of the rear limbs followed by death, while still in the acute stage of Chagas' disease. Hystological analysis of skeletal muscle showed intense inflammatory infiltrates of mononuclear and polymorphonuclear leukocytes, fibroblasts, free red blood cells and IgG deposits in the interstilium of Gastrocnemius (G). Local miofibrillic disintegration and changes in microvessels, nerve fibers and the neuromuscular junction of G were also observed. These results indicate that the acute infection with T. cruzi may cause progressive damage in parasite infected muscle fiber and lead to loss of mobility. |
format |
Article in Journal/Newspaper |
author |
A Lugo de Yarbuh C Colasante |
author_facet |
A Lugo de Yarbuh C Colasante |
author_sort |
A Lugo de Yarbuh |
title |
PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
title_short |
PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
title_full |
PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
title_fullStr |
PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
title_full_unstemmed |
PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION |
title_sort |
pathological aspects of skeletal muscle in experimental trypanosoma cruzi infection |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2000 |
url |
https://doaj.org/article/90ca6f18d03a4ae7a0a9171c66e62d1f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 28, Iss 3 (2000) |
op_relation |
https://produccioncientificaluz.org/index.php/kasmera/article/view/4672 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/90ca6f18d03a4ae7a0a9171c66e62d1f |
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1778521034356424704 |