Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel.
BACKGROUND: Fish-borne zoonotic trematodes (FZT) infections including liver- and minute intestinal flukes are common in Southeast Asia in both humans and domestic animals eating raw fish and since 2010, the liver flukes are recognised as neglected tropical diseases by WHO. Mass drug treatment with p...
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ftdoajarticles:oai:doaj.org/article:90c6da47ba644861adcd230bfea24678 2023-05-15T15:15:14+02:00 Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. Sofie Nissen Lan Anh Thi Nguyen Stig Milan Thamsborg Anders Dalsgaard Maria Vang Johansen 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002625 https://doaj.org/article/90c6da47ba644861adcd230bfea24678 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3879258?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002625 https://doaj.org/article/90c6da47ba644861adcd230bfea24678 PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2625 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002625 2022-12-31T11:22:37Z BACKGROUND: Fish-borne zoonotic trematodes (FZT) infections including liver- and minute intestinal flukes are common in Southeast Asia in both humans and domestic animals eating raw fish and since 2010, the liver flukes are recognised as neglected tropical diseases by WHO. Mass drug treatment with praziquantel is advised for humans, but no recommendations for control of the FZT in the reservoir hosts exist. METHODOLOGY/PRINCIPAL FINDINGS: A study was conducted to assess the ability of praziquantel treatment for control of FZT in farm dogs in an endemic area in Northern Vietnam. Initially, 101 dogs from 73 households were examined for small trematode eggs in their faeces. Forty seven copro-positive dogs were included in the study. Thirty eight dogs received treatment with a single dose of 40 mg/kg of praziquantel. A group of nine dogs were left untreated. Coprological examination for small trematode eggs was performed on day 0, 3, 10, 30, 60, 90 and 120 post treatment. Farmers were questioned about dog keeping practises. All dogs were copro-negative for small trematode eggs on both day 3 and 10 post treatment. From day 30 onwards previously negative dogs became positive again. The reinfection rates were 26.3% (day 30), 45.5% (day 60), 53.1% (day 90), 61.3% (day 120).The nine untreated dogs remained positive throughout the study period. There was no difference in the intensity of infection at day 0 and 120 neither in the treated or untreated group. CONCLUSION: Dogs had easy access to raw fish and did not receive treatment against flukes by their owner. More than 50% of the dogs were reinfected 3 months post treatment. We do not recommend controlling FZT infections in dogs by anthelmintic treatment alone since reinfection occurs fast under the existing farm management systems. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 1 e2625 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sofie Nissen Lan Anh Thi Nguyen Stig Milan Thamsborg Anders Dalsgaard Maria Vang Johansen Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Fish-borne zoonotic trematodes (FZT) infections including liver- and minute intestinal flukes are common in Southeast Asia in both humans and domestic animals eating raw fish and since 2010, the liver flukes are recognised as neglected tropical diseases by WHO. Mass drug treatment with praziquantel is advised for humans, but no recommendations for control of the FZT in the reservoir hosts exist. METHODOLOGY/PRINCIPAL FINDINGS: A study was conducted to assess the ability of praziquantel treatment for control of FZT in farm dogs in an endemic area in Northern Vietnam. Initially, 101 dogs from 73 households were examined for small trematode eggs in their faeces. Forty seven copro-positive dogs were included in the study. Thirty eight dogs received treatment with a single dose of 40 mg/kg of praziquantel. A group of nine dogs were left untreated. Coprological examination for small trematode eggs was performed on day 0, 3, 10, 30, 60, 90 and 120 post treatment. Farmers were questioned about dog keeping practises. All dogs were copro-negative for small trematode eggs on both day 3 and 10 post treatment. From day 30 onwards previously negative dogs became positive again. The reinfection rates were 26.3% (day 30), 45.5% (day 60), 53.1% (day 90), 61.3% (day 120).The nine untreated dogs remained positive throughout the study period. There was no difference in the intensity of infection at day 0 and 120 neither in the treated or untreated group. CONCLUSION: Dogs had easy access to raw fish and did not receive treatment against flukes by their owner. More than 50% of the dogs were reinfected 3 months post treatment. We do not recommend controlling FZT infections in dogs by anthelmintic treatment alone since reinfection occurs fast under the existing farm management systems. |
format |
Article in Journal/Newspaper |
author |
Sofie Nissen Lan Anh Thi Nguyen Stig Milan Thamsborg Anders Dalsgaard Maria Vang Johansen |
author_facet |
Sofie Nissen Lan Anh Thi Nguyen Stig Milan Thamsborg Anders Dalsgaard Maria Vang Johansen |
author_sort |
Sofie Nissen |
title |
Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
title_short |
Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
title_full |
Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
title_fullStr |
Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
title_full_unstemmed |
Reinfection of dogs with fish-borne zoonotic trematodes in northern Vietnam following a single treatment with praziquantel. |
title_sort |
reinfection of dogs with fish-borne zoonotic trematodes in northern vietnam following a single treatment with praziquantel. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002625 https://doaj.org/article/90c6da47ba644861adcd230bfea24678 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2625 (2014) |
op_relation |
http://europepmc.org/articles/PMC3879258?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002625 https://doaj.org/article/90c6da47ba644861adcd230bfea24678 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002625 |
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PLoS Neglected Tropical Diseases |
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8 |
container_issue |
1 |
container_start_page |
e2625 |
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1766345612002852864 |