Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study.
Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The coh...
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ftdoajarticles:oai:doaj.org/article:90544e29c5cb4aee9d0d915e7a08ac6b 2023-05-15T17:22:43+02:00 Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. Sabrina Luke Amy J Hobbs Michaela Smith Catherine Riddell Phil Murphy Calypse Agborsangaya Christina Cantin John Fahey Kenny Der Ann Pederson Chantal Nelson National Maternal Cannabis Working Group 2022-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0276824 https://doaj.org/article/90544e29c5cb4aee9d0d915e7a08ac6b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0276824 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0276824 https://doaj.org/article/90544e29c5cb4aee9d0d915e7a08ac6b PLoS ONE, Vol 17, Iss 11, p e0276824 (2022) Medicine R Science Q article 2022 ftdoajarticles https://doi.org/10.1371/journal.pone.0276824 2022-12-30T19:28:48Z Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. Results The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth (1.80[1.68-1.93] and 1.94[1.77-2.12], respectively), very preterm birth (1.73[1.48-2.02]), low birth weight (1.90[1.79-2.03]), small-for-gestational age (1.21[1.16-1.27]) and large-for-gestational age (1.06[1.01-1.12]), any major congenital anomaly (1.71[1.49-1.97]), caesarean section (1.13[1.09-1.17]), and gestational diabetes (1.32[1.23-1.42]). No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. Conclusions Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are ... Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Newfoundland Canada British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) PLOS ONE 17 11 e0276824 |
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English |
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Medicine R Science Q |
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Medicine R Science Q Sabrina Luke Amy J Hobbs Michaela Smith Catherine Riddell Phil Murphy Calypse Agborsangaya Christina Cantin John Fahey Kenny Der Ann Pederson Chantal Nelson National Maternal Cannabis Working Group Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
topic_facet |
Medicine R Science Q |
description |
Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. Results The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth (1.80[1.68-1.93] and 1.94[1.77-2.12], respectively), very preterm birth (1.73[1.48-2.02]), low birth weight (1.90[1.79-2.03]), small-for-gestational age (1.21[1.16-1.27]) and large-for-gestational age (1.06[1.01-1.12]), any major congenital anomaly (1.71[1.49-1.97]), caesarean section (1.13[1.09-1.17]), and gestational diabetes (1.32[1.23-1.42]). No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. Conclusions Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are ... |
format |
Article in Journal/Newspaper |
author |
Sabrina Luke Amy J Hobbs Michaela Smith Catherine Riddell Phil Murphy Calypse Agborsangaya Christina Cantin John Fahey Kenny Der Ann Pederson Chantal Nelson National Maternal Cannabis Working Group |
author_facet |
Sabrina Luke Amy J Hobbs Michaela Smith Catherine Riddell Phil Murphy Calypse Agborsangaya Christina Cantin John Fahey Kenny Der Ann Pederson Chantal Nelson National Maternal Cannabis Working Group |
author_sort |
Sabrina Luke |
title |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
title_short |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
title_full |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
title_fullStr |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
title_full_unstemmed |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. |
title_sort |
cannabis use in pregnancy and maternal and infant outcomes: a canadian cross-jurisdictional population-based cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pone.0276824 https://doaj.org/article/90544e29c5cb4aee9d0d915e7a08ac6b |
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ENVELOPE(-125.003,-125.003,54.000,54.000) |
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Newfoundland Canada British Columbia |
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Newfoundland Canada British Columbia |
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Newfoundland |
genre_facet |
Newfoundland |
op_source |
PLoS ONE, Vol 17, Iss 11, p e0276824 (2022) |
op_relation |
https://doi.org/10.1371/journal.pone.0276824 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0276824 https://doaj.org/article/90544e29c5cb4aee9d0d915e7a08ac6b |
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https://doi.org/10.1371/journal.pone.0276824 |
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PLOS ONE |
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17 |
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11 |
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