International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests
Abstract Background In malaria elimination settings, the very low levels of transmission now being attained present challenges that demand new strategies to identify and treat low-density infections in both symptomatic and asymptomatic populations. Accordingly, passive case detection activities need...
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ftdoajarticles:oai:doaj.org/article:8f9eda865dd7410aaf0a6e3da66e2cd6 2023-05-15T15:16:30+02:00 International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests Ana Campillo Jennifer Daily Iveth J. González 2017-09-01T00:00:00Z https://doi.org/10.1186/s12936-017-2037-z https://doaj.org/article/8f9eda865dd7410aaf0a6e3da66e2cd6 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-2037-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2037-z 1475-2875 https://doaj.org/article/8f9eda865dd7410aaf0a6e3da66e2cd6 Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017) Malaria Diagnostics Rapid test Elimination Survey Active case detection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-2037-z 2022-12-30T22:37:47Z Abstract Background In malaria elimination settings, the very low levels of transmission now being attained present challenges that demand new strategies to identify and treat low-density infections in both symptomatic and asymptomatic populations. Accordingly, passive case detection activities need to be supplemented by active case detection (ACD) strategies with more sensitive diagnostic tools. Malaria rapid diagnostic tests (RDTs) have provided low- and middle-income countries with unprecedented access to malaria diagnostics. Nevertheless, conventional RDTs miss a potentially important proportion of sub-microscopic infections. Therefore, new combination highly sensitive (HS-)RDTs, able to detect low parasite densities and identify all infected individuals, could support countries implementing ACD strategies for radical cure to accelerate malaria elimination. To address this need, an on-line survey was conducted to gather information from malaria control programme representatives to guide the development of next-generation RDTs. Results Most of respondents confirmed that ACD was a common activity in their programmes (56/75; 75%). Although microscopy was the preferred method in case management and reactive case detection, RDTs were the primary diagnostic tests used in proactive case detection (31/75; 41%). In terms of preferences for species detection in a new combination HS-RDT, data was not one-directional. Survey respondents slightly preferred the Pf/Pv/Pan combination (42%; 21/50), while Pf/Pan was more popular among end-users. Survey respondents also valued a low-cost (< $1.00 USD), lightweight and portable test, able to detect asymptomatic infections and differentiate species, as well as provide immediate results that could be interpreted with the naked eye. In addition, respondents were open to new tests and even to replace the existing ones for ACD (63%; 47/75). Conclusions This survey provided valuable information on the use and current limitations of ACD, on the primary product characteristics for ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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op_collection_id |
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English |
topic |
Malaria Diagnostics Rapid test Elimination Survey Active case detection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Diagnostics Rapid test Elimination Survey Active case detection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ana Campillo Jennifer Daily Iveth J. González International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
topic_facet |
Malaria Diagnostics Rapid test Elimination Survey Active case detection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In malaria elimination settings, the very low levels of transmission now being attained present challenges that demand new strategies to identify and treat low-density infections in both symptomatic and asymptomatic populations. Accordingly, passive case detection activities need to be supplemented by active case detection (ACD) strategies with more sensitive diagnostic tools. Malaria rapid diagnostic tests (RDTs) have provided low- and middle-income countries with unprecedented access to malaria diagnostics. Nevertheless, conventional RDTs miss a potentially important proportion of sub-microscopic infections. Therefore, new combination highly sensitive (HS-)RDTs, able to detect low parasite densities and identify all infected individuals, could support countries implementing ACD strategies for radical cure to accelerate malaria elimination. To address this need, an on-line survey was conducted to gather information from malaria control programme representatives to guide the development of next-generation RDTs. Results Most of respondents confirmed that ACD was a common activity in their programmes (56/75; 75%). Although microscopy was the preferred method in case management and reactive case detection, RDTs were the primary diagnostic tests used in proactive case detection (31/75; 41%). In terms of preferences for species detection in a new combination HS-RDT, data was not one-directional. Survey respondents slightly preferred the Pf/Pv/Pan combination (42%; 21/50), while Pf/Pan was more popular among end-users. Survey respondents also valued a low-cost (< $1.00 USD), lightweight and portable test, able to detect asymptomatic infections and differentiate species, as well as provide immediate results that could be interpreted with the naked eye. In addition, respondents were open to new tests and even to replace the existing ones for ACD (63%; 47/75). Conclusions This survey provided valuable information on the use and current limitations of ACD, on the primary product characteristics for ... |
format |
Article in Journal/Newspaper |
author |
Ana Campillo Jennifer Daily Iveth J. González |
author_facet |
Ana Campillo Jennifer Daily Iveth J. González |
author_sort |
Ana Campillo |
title |
International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
title_short |
International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
title_full |
International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
title_fullStr |
International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
title_full_unstemmed |
International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
title_sort |
international survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-2037-z https://doaj.org/article/8f9eda865dd7410aaf0a6e3da66e2cd6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-2037-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2037-z 1475-2875 https://doaj.org/article/8f9eda865dd7410aaf0a6e3da66e2cd6 |
op_doi |
https://doi.org/10.1186/s12936-017-2037-z |
container_title |
Malaria Journal |
container_volume |
16 |
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1 |
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1766346795495981056 |