Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes
Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sb v (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1990
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ftdoajarticles:oai:doaj.org/article:8f81d0ecb2324e9eb88b1b0c5eb1f031 2024-09-09T19:28:09+00:00 Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes Joel Paulo R. Veiga Rashida Khanam Tânia T. Rosa Luiz F. Junqueira Jr. Plínio C. Brant Alberto N. Raick Horacio Friedman Phillip D. Marsden 1990-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651990000400012 https://doaj.org/article/8f81d0ecb2324e9eb88b1b0c5eb1f031 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000400012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651990000400012 0036-4665 1678-9946 https://doaj.org/article/8f81d0ecb2324e9eb88b1b0c5eb1f031 Revista do Instituto de Medicina Tropical de São Paulo, Vol 32, Iss 4, Pp 304-309 (1990) Pentavalent antimonial Renal function Urinary concentrating capacity Acute tubular necrosis Rat Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1990 ftdoajarticles https://doi.org/10.1590/S0036-46651990000400012 2024-08-05T17:49:30Z Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sb v (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis. Estudou-se a função renal de ratos tratados com Glucantime (Antimoniato de Meglumine, Rhodia) e Pentostam (Estibogluconato de Sódio, Wellcome) na dose de 30 mg de Sb v por 100 g de peso por dia, durante 30 dias. Observou-se um distúrio na concentração urinária, que foi reversível 7 dias após cessada a administração das drogas. O estudo histopatológico do rim, por meio da microscopia óptica, não evidenciou alterações significativas. Por outro lado, ratos tratados com altas doses dos antimoniais (200 mg de Sb v por 100 g de peso por dia) mostraram alterações funcionais e histopatológicas renais compatíveis com necrose tubular aguda. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) Arctic Revista do Instituto de Medicina Tropical de São Paulo 32 4 304 309 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Pentavalent antimonial Renal function Urinary concentrating capacity Acute tubular necrosis Rat Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Pentavalent antimonial Renal function Urinary concentrating capacity Acute tubular necrosis Rat Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Joel Paulo R. Veiga Rashida Khanam Tânia T. Rosa Luiz F. Junqueira Jr. Plínio C. Brant Alberto N. Raick Horacio Friedman Phillip D. Marsden Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
topic_facet |
Pentavalent antimonial Renal function Urinary concentrating capacity Acute tubular necrosis Rat Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sb v (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis. Estudou-se a função renal de ratos tratados com Glucantime (Antimoniato de Meglumine, Rhodia) e Pentostam (Estibogluconato de Sódio, Wellcome) na dose de 30 mg de Sb v por 100 g de peso por dia, durante 30 dias. Observou-se um distúrio na concentração urinária, que foi reversível 7 dias após cessada a administração das drogas. O estudo histopatológico do rim, por meio da microscopia óptica, não evidenciou alterações significativas. Por outro lado, ratos tratados com altas doses dos antimoniais (200 mg de Sb v por 100 g de peso por dia) mostraram alterações funcionais e histopatológicas renais compatíveis com necrose tubular aguda. |
format |
Article in Journal/Newspaper |
author |
Joel Paulo R. Veiga Rashida Khanam Tânia T. Rosa Luiz F. Junqueira Jr. Plínio C. Brant Alberto N. Raick Horacio Friedman Phillip D. Marsden |
author_facet |
Joel Paulo R. Veiga Rashida Khanam Tânia T. Rosa Luiz F. Junqueira Jr. Plínio C. Brant Alberto N. Raick Horacio Friedman Phillip D. Marsden |
author_sort |
Joel Paulo R. Veiga |
title |
Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
title_short |
Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
title_full |
Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
title_fullStr |
Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
title_full_unstemmed |
Pentavalent antimonial nephrotoxicity in the rat Disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
title_sort |
pentavalent antimonial nephrotoxicity in the rat disfunção tubular renal em ratos tratados com antimoniais pentavalentes |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1990 |
url |
https://doi.org/10.1590/S0036-46651990000400012 https://doaj.org/article/8f81d0ecb2324e9eb88b1b0c5eb1f031 |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Aguda Arctic |
geographic_facet |
Aguda Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 32, Iss 4, Pp 304-309 (1990) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000400012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651990000400012 0036-4665 1678-9946 https://doaj.org/article/8f81d0ecb2324e9eb88b1b0c5eb1f031 |
op_doi |
https://doi.org/10.1590/S0036-46651990000400012 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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32 |
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4 |
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304 |
op_container_end_page |
309 |
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