Ebola viral disease: a review literature
Ebola virus is transmitted to people as a result of direct contact with body fluids containing virus of an infected patient. The incubation period usually lasts 5 to 7 d and approximately 95% of the patients appear signs within 21 d after exposure. Typical features include fever, profound weakness,...
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ftdoajarticles:oai:doaj.org/article:8f65ad9a0a694aa6b26659b79454e417 2023-05-15T15:12:22+02:00 Ebola viral disease: a review literature Saeed Reza Jamali Moghadam Negar Omidi Samaneh Bayrami Sepideh Jamali Moghadam SeyedAhmad SeyedAlinaghi 2015-04-01T00:00:00Z https://doi.org/10.1016/S2221-1691(15)30341-5 https://doaj.org/article/8f65ad9a0a694aa6b26659b79454e417 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115303415 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30341-5 https://doaj.org/article/8f65ad9a0a694aa6b26659b79454e417 Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 260-267 (2015) Filoviridae Ebola Outbreak Reservoir Transmission Symptoms Hemorrhagic fever Index case ELISA Vaccine Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/S2221-1691(15)30341-5 2022-12-31T13:29:45Z Ebola virus is transmitted to people as a result of direct contact with body fluids containing virus of an infected patient. The incubation period usually lasts 5 to 7 d and approximately 95% of the patients appear signs within 21 d after exposure. Typical features include fever, profound weakness, diarrhea, abdominal pain, cramping, nausea and vomiting for 3-5 days and maybe persisting for up to a week. Laboratory complications including elevated aminotransferase levels, marked lymphocytopenia, and thrombocytopenia may have occurred. Hemorrhagic fever occurs in less than half of patients and it takes place most commonly in the gastrointestinal tract. The symptoms progress over the time and patients suffer from dehydration, stupor, confusion, hypotension, multi-organ failure, leading to fulminant shock and eventually death. The most general assays used for antibody detection are direct IgG and IgM ELISAs and IgM capture ELISA. An IgM or rising IgG titer (four-fold) contributes to strong presumptive diagnosis. Currently neither a licensed vaccine nor an approved treatment is available for human use. Passive transfer of serum collected from survivors of Junin virus or Lassa virus, equine IgG product from horses hypervaccinated with Ebola virus, a “cocktail” of humanized-mouse antibodies (ZMapp), recombinant inhibitor of factor VIIa/tissue factor, activated protein C, RNA-polymerase inhibitors and small interfering RNA nano particles are among the therapies in development. Preclinical evaluation is also underway for various vaccine candidates. One is a chimpanzee adenovirus vector vaccine; other vaccines involve replication-defective adenovirus serotype 5 and recombinant vesicular stomatitis virus. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 4 260 267 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Filoviridae Ebola Outbreak Reservoir Transmission Symptoms Hemorrhagic fever Index case ELISA Vaccine Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Filoviridae Ebola Outbreak Reservoir Transmission Symptoms Hemorrhagic fever Index case ELISA Vaccine Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Saeed Reza Jamali Moghadam Negar Omidi Samaneh Bayrami Sepideh Jamali Moghadam SeyedAhmad SeyedAlinaghi Ebola viral disease: a review literature |
topic_facet |
Filoviridae Ebola Outbreak Reservoir Transmission Symptoms Hemorrhagic fever Index case ELISA Vaccine Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Ebola virus is transmitted to people as a result of direct contact with body fluids containing virus of an infected patient. The incubation period usually lasts 5 to 7 d and approximately 95% of the patients appear signs within 21 d after exposure. Typical features include fever, profound weakness, diarrhea, abdominal pain, cramping, nausea and vomiting for 3-5 days and maybe persisting for up to a week. Laboratory complications including elevated aminotransferase levels, marked lymphocytopenia, and thrombocytopenia may have occurred. Hemorrhagic fever occurs in less than half of patients and it takes place most commonly in the gastrointestinal tract. The symptoms progress over the time and patients suffer from dehydration, stupor, confusion, hypotension, multi-organ failure, leading to fulminant shock and eventually death. The most general assays used for antibody detection are direct IgG and IgM ELISAs and IgM capture ELISA. An IgM or rising IgG titer (four-fold) contributes to strong presumptive diagnosis. Currently neither a licensed vaccine nor an approved treatment is available for human use. Passive transfer of serum collected from survivors of Junin virus or Lassa virus, equine IgG product from horses hypervaccinated with Ebola virus, a “cocktail” of humanized-mouse antibodies (ZMapp), recombinant inhibitor of factor VIIa/tissue factor, activated protein C, RNA-polymerase inhibitors and small interfering RNA nano particles are among the therapies in development. Preclinical evaluation is also underway for various vaccine candidates. One is a chimpanzee adenovirus vector vaccine; other vaccines involve replication-defective adenovirus serotype 5 and recombinant vesicular stomatitis virus. |
format |
Article in Journal/Newspaper |
author |
Saeed Reza Jamali Moghadam Negar Omidi Samaneh Bayrami Sepideh Jamali Moghadam SeyedAhmad SeyedAlinaghi |
author_facet |
Saeed Reza Jamali Moghadam Negar Omidi Samaneh Bayrami Sepideh Jamali Moghadam SeyedAhmad SeyedAlinaghi |
author_sort |
Saeed Reza Jamali Moghadam |
title |
Ebola viral disease: a review literature |
title_short |
Ebola viral disease: a review literature |
title_full |
Ebola viral disease: a review literature |
title_fullStr |
Ebola viral disease: a review literature |
title_full_unstemmed |
Ebola viral disease: a review literature |
title_sort |
ebola viral disease: a review literature |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/S2221-1691(15)30341-5 https://doaj.org/article/8f65ad9a0a694aa6b26659b79454e417 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 260-267 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115303415 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30341-5 https://doaj.org/article/8f65ad9a0a694aa6b26659b79454e417 |
op_doi |
https://doi.org/10.1016/S2221-1691(15)30341-5 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
4 |
container_start_page |
260 |
op_container_end_page |
267 |
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1766343066068713472 |