Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
ABSTRACT Human immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infe...
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ftdoajarticles:oai:doaj.org/article:8f47d52eaf9f438a9275d303bbfdc220 2024-09-09T19:25:20+00:00 Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review Flávia Esper Dahy Christina T. G. Novaes Gabriela A. Bandeira Laís F. Ramin Augusto César Penalva de Oliveira Jerusa Smid 2021-03-01T00:00:00Z https://doi.org/10.1590/s1678-9946202163023 https://doaj.org/article/8f47d52eaf9f438a9275d303bbfdc220 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100504&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163023 https://doaj.org/article/8f47d52eaf9f438a9275d303bbfdc220 Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) HIV Dementia Prion disease Creutzfeldt-Jakob disease HAND Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1590/s1678-9946202163023 2024-08-05T17:49:31Z ABSTRACT Human immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly patients. Our objective is to describe two cases of PLHIV presenting with controlled infections and sCJD, and to review the literature. Our patients were younger than expected for sCJD and one of them had a longer disease course. As aging is expected to occur earlier in PLHIV, sCJD must be excluded in younger PLHIV presenting with RPD and without CNS infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 63 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
HIV Dementia Prion disease Creutzfeldt-Jakob disease HAND Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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HIV Dementia Prion disease Creutzfeldt-Jakob disease HAND Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Flávia Esper Dahy Christina T. G. Novaes Gabriela A. Bandeira Laís F. Ramin Augusto César Penalva de Oliveira Jerusa Smid Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
topic_facet |
HIV Dementia Prion disease Creutzfeldt-Jakob disease HAND Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Human immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly patients. Our objective is to describe two cases of PLHIV presenting with controlled infections and sCJD, and to review the literature. Our patients were younger than expected for sCJD and one of them had a longer disease course. As aging is expected to occur earlier in PLHIV, sCJD must be excluded in younger PLHIV presenting with RPD and without CNS infection. |
format |
Article in Journal/Newspaper |
author |
Flávia Esper Dahy Christina T. G. Novaes Gabriela A. Bandeira Laís F. Ramin Augusto César Penalva de Oliveira Jerusa Smid |
author_facet |
Flávia Esper Dahy Christina T. G. Novaes Gabriela A. Bandeira Laís F. Ramin Augusto César Penalva de Oliveira Jerusa Smid |
author_sort |
Flávia Esper Dahy |
title |
Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
title_short |
Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
title_full |
Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
title_fullStr |
Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
title_full_unstemmed |
Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review |
title_sort |
sporadic creutzfeldt-jakob disease in two clinically and virologically controlled brazilian hiv patients who progressed rapidly to dementia: case reports and literature review |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2021 |
url |
https://doi.org/10.1590/s1678-9946202163023 https://doaj.org/article/8f47d52eaf9f438a9275d303bbfdc220 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100504&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163023 https://doaj.org/article/8f47d52eaf9f438a9275d303bbfdc220 |
op_doi |
https://doi.org/10.1590/s1678-9946202163023 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
63 |
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