Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population
The aim of this study was to investigate the relationship between the HTR2A 1438A/G (rs6311) SNP and the risk of nicotine addiction in Yakuts. Methods and Results: A total of 292 people of Yakut nationality were tested (77 women and 215 men). Two groups of examined persons were formed: smokers (n=14...
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International Medical Research and Development Corporation
2022
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ftdoajarticles:oai:doaj.org/article:8f3bcd1616b64f4cb710c6cd704d590f 2023-05-15T18:45:16+02:00 Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population Nadezhda I. Pavlova Aleksey A. Bochurov Vladislav A. Alekseev Aleksandra T. Diakonova Vladimir V. Dodokhov Khariton A. Kurtanov 2022-03-01T00:00:00Z https://doi.org/10.21103/Article12(1)_OA18 https://doaj.org/article/8f3bcd1616b64f4cb710c6cd704d590f EN eng International Medical Research and Development Corporation http://www.ijbm.org/articles/i45/ijbm_12(1)_oa18.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article12(1)_OA18 2158-0510 2158-0529 https://doaj.org/article/8f3bcd1616b64f4cb710c6cd704d590f International Journal of Biomedicine, Vol 12, Iss 1, Pp 151-154 (2022) htr2a rs6311 snp addictive behavior Medicine R article 2022 ftdoajarticles https://doi.org/10.21103/Article12(1)_OA18 2022-12-31T12:59:21Z The aim of this study was to investigate the relationship between the HTR2A 1438A/G (rs6311) SNP and the risk of nicotine addiction in Yakuts. Methods and Results: A total of 292 people of Yakut nationality were tested (77 women and 215 men). Two groups of examined persons were formed: smokers (n=141) and non-smokers (NS, n=151). To determine the association of the studied SNP with the degree of smoking, the smoker group was divided into two subgroups: Heavy smokers (HS) and Light smokers (LS). Subjects who were smokers were classified based on their consumption of cigarettes per day (cpd), as follows: LS (n=10), those who consumed between 1 and 10 cpd, and HS (n=131), those who consumed ≥20 cpd. The study of the HTR2A 1438A/G (rs6311) SNP was performed by PCR and RFLP analysis. The A allele of the HTR2A 1438A/G (rs6311) SNP was associated with more of a risk for the HS group than the LS. Using the A allele as a risk factor, RR analysis showed a significant association with a risk factor when comparing HS with LS (RR=1.086; 95% CI=1.032-1.142; P=0.049). The analysis of the OR and RR between the HS and LS showed that the AA and AG genotypes were associated with an increased risk for heavy smoking (OR=9.714; 95% CI=1.196-78.874; RR =1.126; 95% CI=1.027-1.235; P=0.026). We cannot dismiss the possibility that our results may reflect the small sample size. Despite this potential limitation, the significant associations should not be disregarded and merit further investigation for clarification of these results. Article in Journal/Newspaper Yakuts Directory of Open Access Journals: DOAJ Articles International Journal of Biomedicine 12 1 151 154 |
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topic |
htr2a rs6311 snp addictive behavior Medicine R |
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htr2a rs6311 snp addictive behavior Medicine R Nadezhda I. Pavlova Aleksey A. Bochurov Vladislav A. Alekseev Aleksandra T. Diakonova Vladimir V. Dodokhov Khariton A. Kurtanov Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
topic_facet |
htr2a rs6311 snp addictive behavior Medicine R |
description |
The aim of this study was to investigate the relationship between the HTR2A 1438A/G (rs6311) SNP and the risk of nicotine addiction in Yakuts. Methods and Results: A total of 292 people of Yakut nationality were tested (77 women and 215 men). Two groups of examined persons were formed: smokers (n=141) and non-smokers (NS, n=151). To determine the association of the studied SNP with the degree of smoking, the smoker group was divided into two subgroups: Heavy smokers (HS) and Light smokers (LS). Subjects who were smokers were classified based on their consumption of cigarettes per day (cpd), as follows: LS (n=10), those who consumed between 1 and 10 cpd, and HS (n=131), those who consumed ≥20 cpd. The study of the HTR2A 1438A/G (rs6311) SNP was performed by PCR and RFLP analysis. The A allele of the HTR2A 1438A/G (rs6311) SNP was associated with more of a risk for the HS group than the LS. Using the A allele as a risk factor, RR analysis showed a significant association with a risk factor when comparing HS with LS (RR=1.086; 95% CI=1.032-1.142; P=0.049). The analysis of the OR and RR between the HS and LS showed that the AA and AG genotypes were associated with an increased risk for heavy smoking (OR=9.714; 95% CI=1.196-78.874; RR =1.126; 95% CI=1.027-1.235; P=0.026). We cannot dismiss the possibility that our results may reflect the small sample size. Despite this potential limitation, the significant associations should not be disregarded and merit further investigation for clarification of these results. |
format |
Article in Journal/Newspaper |
author |
Nadezhda I. Pavlova Aleksey A. Bochurov Vladislav A. Alekseev Aleksandra T. Diakonova Vladimir V. Dodokhov Khariton A. Kurtanov |
author_facet |
Nadezhda I. Pavlova Aleksey A. Bochurov Vladislav A. Alekseev Aleksandra T. Diakonova Vladimir V. Dodokhov Khariton A. Kurtanov |
author_sort |
Nadezhda I. Pavlova |
title |
Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
title_short |
Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
title_full |
Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
title_fullStr |
Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
title_full_unstemmed |
Analysis of the Association of 5-Hydroxytryptamine Receptor 2A Gene Variants in Nicotine Addiction in the Yakut Population |
title_sort |
analysis of the association of 5-hydroxytryptamine receptor 2a gene variants in nicotine addiction in the yakut population |
publisher |
International Medical Research and Development Corporation |
publishDate |
2022 |
url |
https://doi.org/10.21103/Article12(1)_OA18 https://doaj.org/article/8f3bcd1616b64f4cb710c6cd704d590f |
genre |
Yakuts |
genre_facet |
Yakuts |
op_source |
International Journal of Biomedicine, Vol 12, Iss 1, Pp 151-154 (2022) |
op_relation |
http://www.ijbm.org/articles/i45/ijbm_12(1)_oa18.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article12(1)_OA18 2158-0510 2158-0529 https://doaj.org/article/8f3bcd1616b64f4cb710c6cd704d590f |
op_doi |
https://doi.org/10.21103/Article12(1)_OA18 |
container_title |
International Journal of Biomedicine |
container_volume |
12 |
container_issue |
1 |
container_start_page |
151 |
op_container_end_page |
154 |
_version_ |
1766236315288862720 |