Multiple uses of fibrin sealant for nervous system treatment following injury and disease
Abstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, incre...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:8ecd9f2837f54f3d8a2070db34af3afc 2023-05-15T15:10:49+02:00 Multiple uses of fibrin sealant for nervous system treatment following injury and disease Natalia Perussi Biscola Luciana Politti Cartarozzi Suzana Ulian-Benitez Roberta Barbizan Mateus Vidigal Castro Aline Barroso Spejo Rui Seabra Ferreira Jr. Benedito Barraviera Alexandre Leite Rodrigues Oliveira 2017-04-01T00:00:00Z https://doi.org/10.1186/s40409-017-0103-1 https://doaj.org/article/8ecd9f2837f54f3d8a2070db34af3afc EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-017-0103-1 https://doaj.org/article/8ecd9f2837f54f3d8a2070db34af3afc Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 0 (2017) Central nervous system Peripheral nervous system Commercial fibrin sealant New heterologous fibrin sealant Nervous system injury Fibrin tissue adhesive Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2017 ftdoajarticles https://doi.org/10.1186/s40409-017-0103-1 2022-12-31T00:35:58Z Abstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery. To date, several studies have demonstrated that human blood derived fibrin sealant produces positive effects in different interventions, becoming an efficient alternative to suturing. To provide an alternative to homologous fibrin sealants, the Center for the Study of Venoms and Venomous Animals (CEVAP, Brazil) has proposed a new bioproduct composed of certified animal components, including a thrombin-like enzyme obtained from snake venom and bubaline fibrinogen. Thus, the present review brings up to date literature assessment on the use of fibrin sealant for nervous system repair and positions the new heterologous bioproduct from CEVAP as an alternative to the commercial counterparts. In this way, clinical and pre-clinical data are discussed in different topics, ranging from central nervous system to peripheral nervous system applications, specifying positive results as well as future enhancements that are necessary for improving the use of fibrin sealant therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 23 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Central nervous system Peripheral nervous system Commercial fibrin sealant New heterologous fibrin sealant Nervous system injury Fibrin tissue adhesive Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Central nervous system Peripheral nervous system Commercial fibrin sealant New heterologous fibrin sealant Nervous system injury Fibrin tissue adhesive Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Natalia Perussi Biscola Luciana Politti Cartarozzi Suzana Ulian-Benitez Roberta Barbizan Mateus Vidigal Castro Aline Barroso Spejo Rui Seabra Ferreira Jr. Benedito Barraviera Alexandre Leite Rodrigues Oliveira Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
topic_facet |
Central nervous system Peripheral nervous system Commercial fibrin sealant New heterologous fibrin sealant Nervous system injury Fibrin tissue adhesive Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery. To date, several studies have demonstrated that human blood derived fibrin sealant produces positive effects in different interventions, becoming an efficient alternative to suturing. To provide an alternative to homologous fibrin sealants, the Center for the Study of Venoms and Venomous Animals (CEVAP, Brazil) has proposed a new bioproduct composed of certified animal components, including a thrombin-like enzyme obtained from snake venom and bubaline fibrinogen. Thus, the present review brings up to date literature assessment on the use of fibrin sealant for nervous system repair and positions the new heterologous bioproduct from CEVAP as an alternative to the commercial counterparts. In this way, clinical and pre-clinical data are discussed in different topics, ranging from central nervous system to peripheral nervous system applications, specifying positive results as well as future enhancements that are necessary for improving the use of fibrin sealant therapy. |
format |
Article in Journal/Newspaper |
author |
Natalia Perussi Biscola Luciana Politti Cartarozzi Suzana Ulian-Benitez Roberta Barbizan Mateus Vidigal Castro Aline Barroso Spejo Rui Seabra Ferreira Jr. Benedito Barraviera Alexandre Leite Rodrigues Oliveira |
author_facet |
Natalia Perussi Biscola Luciana Politti Cartarozzi Suzana Ulian-Benitez Roberta Barbizan Mateus Vidigal Castro Aline Barroso Spejo Rui Seabra Ferreira Jr. Benedito Barraviera Alexandre Leite Rodrigues Oliveira |
author_sort |
Natalia Perussi Biscola |
title |
Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
title_short |
Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
title_full |
Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
title_fullStr |
Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
title_full_unstemmed |
Multiple uses of fibrin sealant for nervous system treatment following injury and disease |
title_sort |
multiple uses of fibrin sealant for nervous system treatment following injury and disease |
publisher |
SciELO |
publishDate |
2017 |
url |
https://doi.org/10.1186/s40409-017-0103-1 https://doaj.org/article/8ecd9f2837f54f3d8a2070db34af3afc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 0 (2017) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-017-0103-1 https://doaj.org/article/8ecd9f2837f54f3d8a2070db34af3afc |
op_doi |
https://doi.org/10.1186/s40409-017-0103-1 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
23 |
container_issue |
1 |
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1766341771696013312 |