Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital
Objective. To 1) describe clinical characteristics of adult patients in Chile with severe acute respiratory infections (SARI) associated with influenza viruses, and 2) analyze virus subtypes identified in specimens collected from those patients, hospital resources used in clinical management, clinic...
Published in: | Revista Panamericana de Salud Pública |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English Spanish Portuguese |
Published: |
Pan American Health Organization
2019
|
Subjects: | |
Online Access: | https://doi.org/10.26633/RPSP.2019.1 https://doaj.org/article/8eb69861072d45b9b3661c217fe05a2f |
id |
ftdoajarticles:oai:doaj.org/article:8eb69861072d45b9b3661c217fe05a2f |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:8eb69861072d45b9b3661c217fe05a2f 2023-05-15T15:15:01+02:00 Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital Alberto Fica Viviana Sotomayor Rodrigo Fasce Jeannette Dabanch Andrés Soto Paulo Charpentier Gonzalo Guerrero Felipe Olivares Vjera Triantafilo Nathalie El Omeiri Marina Gaínza-Lein 2019-01-01T00:00:00Z https://doi.org/10.26633/RPSP.2019.1 https://doaj.org/article/8eb69861072d45b9b3661c217fe05a2f EN ES PT eng spa por Pan American Health Organization http://iris.paho.org/xmlui/handle/123456789/49745 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2019.1 https://doaj.org/article/8eb69861072d45b9b3661c217fe05a2f Revista Panamericana de Salud Pública, Vol 43, Pp 1-11 (2019) Influenza human respiratory tract infections adult hospitalization risk factors fatal outcome Chile Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.26633/RPSP.2019.1 2022-12-30T21:14:00Z Objective. To 1) describe clinical characteristics of adult patients in Chile with severe acute respiratory infections (SARI) associated with influenza viruses, and 2) analyze virus subtypes identified in specimens collected from those patients, hospital resources used in clinical management, clinical evolution, and risk factors associated with a fatal outcome, using observational data from the SARI surveillance network (SARInet). Methods. Adults hospitalized from 1 July 2011 to 31 December 2015 with influenza-associated SARI at a SARI sentinel surveillance hospital in Santiago were identified and the presence of influenza in all cases confirmed by reverse transcription polymerase chain reaction (RT-PCR), using respiratory samples. Results. A total of 221 patients (mean age: 74.1 years) were hospitalized with influenza-associated SARI during the study period. Of this study cohort, 91.4% had risk factors for complications and 34.3% had been vaccinated during the most recent campaign. Pneumonia was the most frequent clinical manifestation, occurring in 57.0% of the cohort; other manifestations included influenza-like illness, exacerbated chronic bronchitis, decompensated heart failure, and asthmatic crisis. Cases occurred year-round, with an epidemic peak during autumn–winter. Both influenza A (H1N1pdm09 and H3N2) and B virus co-circulated. Critical care beds were required for 26.7% of the cohort, and 19.5% needed ventilatory assistance. Multivariate analysis identified four significant factors associated with in-hospital mortality: 1) being bedridden (adjusted odds ratio (aOR): 22.3; 95% confidence interval (CI): 3.0–164); 2) admission to critical care unit (aOR: 8.9; CI: 1.44–55); 3) Pa02/Fi02 ratio < 250 (aOR: 5.8; CI: 1.02–33); and 4) increased serum creatinine concentration (> 1 mg/dL) (aOR: 5.47; CI: 1.20–24). Seasonal influenza vaccine was identified as a significant protective factor (aOR: 0.14; CI: 0.021–0.90). Conclusions. Influenza-associated SARI affected mainly elderly patients with underlying ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 43 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Influenza human respiratory tract infections adult hospitalization risk factors fatal outcome Chile Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Influenza human respiratory tract infections adult hospitalization risk factors fatal outcome Chile Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alberto Fica Viviana Sotomayor Rodrigo Fasce Jeannette Dabanch Andrés Soto Paulo Charpentier Gonzalo Guerrero Felipe Olivares Vjera Triantafilo Nathalie El Omeiri Marina Gaínza-Lein Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
topic_facet |
Influenza human respiratory tract infections adult hospitalization risk factors fatal outcome Chile Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Objective. To 1) describe clinical characteristics of adult patients in Chile with severe acute respiratory infections (SARI) associated with influenza viruses, and 2) analyze virus subtypes identified in specimens collected from those patients, hospital resources used in clinical management, clinical evolution, and risk factors associated with a fatal outcome, using observational data from the SARI surveillance network (SARInet). Methods. Adults hospitalized from 1 July 2011 to 31 December 2015 with influenza-associated SARI at a SARI sentinel surveillance hospital in Santiago were identified and the presence of influenza in all cases confirmed by reverse transcription polymerase chain reaction (RT-PCR), using respiratory samples. Results. A total of 221 patients (mean age: 74.1 years) were hospitalized with influenza-associated SARI during the study period. Of this study cohort, 91.4% had risk factors for complications and 34.3% had been vaccinated during the most recent campaign. Pneumonia was the most frequent clinical manifestation, occurring in 57.0% of the cohort; other manifestations included influenza-like illness, exacerbated chronic bronchitis, decompensated heart failure, and asthmatic crisis. Cases occurred year-round, with an epidemic peak during autumn–winter. Both influenza A (H1N1pdm09 and H3N2) and B virus co-circulated. Critical care beds were required for 26.7% of the cohort, and 19.5% needed ventilatory assistance. Multivariate analysis identified four significant factors associated with in-hospital mortality: 1) being bedridden (adjusted odds ratio (aOR): 22.3; 95% confidence interval (CI): 3.0–164); 2) admission to critical care unit (aOR: 8.9; CI: 1.44–55); 3) Pa02/Fi02 ratio < 250 (aOR: 5.8; CI: 1.02–33); and 4) increased serum creatinine concentration (> 1 mg/dL) (aOR: 5.47; CI: 1.20–24). Seasonal influenza vaccine was identified as a significant protective factor (aOR: 0.14; CI: 0.021–0.90). Conclusions. Influenza-associated SARI affected mainly elderly patients with underlying ... |
format |
Article in Journal/Newspaper |
author |
Alberto Fica Viviana Sotomayor Rodrigo Fasce Jeannette Dabanch Andrés Soto Paulo Charpentier Gonzalo Guerrero Felipe Olivares Vjera Triantafilo Nathalie El Omeiri Marina Gaínza-Lein |
author_facet |
Alberto Fica Viviana Sotomayor Rodrigo Fasce Jeannette Dabanch Andrés Soto Paulo Charpentier Gonzalo Guerrero Felipe Olivares Vjera Triantafilo Nathalie El Omeiri Marina Gaínza-Lein |
author_sort |
Alberto Fica |
title |
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
title_short |
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
title_full |
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
title_fullStr |
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
title_full_unstemmed |
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital |
title_sort |
severe acute respiratory infections (sari) from influenza in adult patients in chile: the experience of a sentinel hospital |
publisher |
Pan American Health Organization |
publishDate |
2019 |
url |
https://doi.org/10.26633/RPSP.2019.1 https://doaj.org/article/8eb69861072d45b9b3661c217fe05a2f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 43, Pp 1-11 (2019) |
op_relation |
http://iris.paho.org/xmlui/handle/123456789/49745 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2019.1 https://doaj.org/article/8eb69861072d45b9b3661c217fe05a2f |
op_doi |
https://doi.org/10.26633/RPSP.2019.1 |
container_title |
Revista Panamericana de Salud Pública |
container_volume |
43 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1766345404057649152 |