Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar
Abstract Background Estimation of prevalence of Strongyloides stercoralis infection is required in endemic areas, in order to identify areas in need of control programmes. Data on prevalence of strongyloidiasis in Madagascar are scant. Aim of this work was to estimate prevalence of S. stercoralis in...
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ftdoajarticles:oai:doaj.org/article:8e2c65a2ed734a30a1b352d987aef62b 2024-09-09T19:27:36+00:00 Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar Salvatore Scarso Rivo Andry Rakotoarivelo Jana Christina Hey Tahinamandranto Rasamoelina Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Nantenaina Mathieu Razafindralava Aaron Remkes Njary Rakotozandrindrainy Clara Fabienne Rasoamanamihaja Norbert Georg Schwarz Jürgen May Raphael Rakotozandrindrainy Valentina Marchese Fabio Formenti Francesca Perandin Francesca Tamarozzi Cristina Mazzi Daniela Fusco Dora Buonfrate 2024-07-01T00:00:00Z https://doi.org/10.1186/s41182-024-00619-y https://doaj.org/article/8e2c65a2ed734a30a1b352d987aef62b EN eng BMC https://doi.org/10.1186/s41182-024-00619-y https://doaj.org/toc/1349-4147 doi:10.1186/s41182-024-00619-y 1349-4147 https://doaj.org/article/8e2c65a2ed734a30a1b352d987aef62b Tropical Medicine and Health, Vol 52, Iss 1, Pp 1-8 (2024) Strongyloides stercoralis Strongyloidiasis Helminth Prevalence study Madagascar Ascaris lumbricoides Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.1186/s41182-024-00619-y 2024-08-05T17:50:07Z Abstract Background Estimation of prevalence of Strongyloides stercoralis infection is required in endemic areas, in order to identify areas in need of control programmes. Data on prevalence of strongyloidiasis in Madagascar are scant. Aim of this work was to estimate prevalence of S. stercoralis in four districts of Madagascar. Methods Fecal and serum samples collected in the context of a previous study on schistosomiasis were tested with S. stercoralis real-time PCR and serology, respectively. A multiplex real-time PCR for Ascaris lumbricoides, Ancylostoma duodenalis, Necator americanus, and Trichuris trichiura was done on fecal samples collected in the areas demonstrating higher prevalence of strongyloidiasis. Comparisons between proportions were made using Fisher exact test, with false discovery rate correction used for post-hoc comparisons. A multivariable Firth logistic regression model was used to assess potential risk factors for S. stercoralis infection. Results Overall, 1775 serum samples were tested, of which 102 of 487 (20.9%) and 104 of 296 (35.2%) were serological-positive in Marovoay and in Vatomandry districts (both coastal areas), respectively, compared to 28 of 496 (5.6%) and 30 of 496 (6.1%) in Tsiroanomandidy and in Ambositra districts (both highlands), respectively (adj. p < 0.001). PCR for S. stercoralis was positive in 15 of 210 (7.1%) and in 11 of 296 (3.7%) samples from Marovoay from Vatomandry, respectively, while was negative for all samples tested in the other two districts. High prevalence of A. lumbricoides (45.9%), hookworm (44.6%) and T. trichiura (32.1%) was found in Vatomandry. In the multivariable analysis, strongyloidiasis was associated with hookworm infection. Hookworm infection was also associated with male sex and lower education level. Conclusions S. stercoralis prevalence proved higher in coastal areas compared to highlands. Different climatic conditions may explain this distribution, along with previous rounds of anthelminthics distributed in the country, which may ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 52 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Strongyloides stercoralis Strongyloidiasis Helminth Prevalence study Madagascar Ascaris lumbricoides Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Strongyloides stercoralis Strongyloidiasis Helminth Prevalence study Madagascar Ascaris lumbricoides Arctic medicine. Tropical medicine RC955-962 Salvatore Scarso Rivo Andry Rakotoarivelo Jana Christina Hey Tahinamandranto Rasamoelina Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Nantenaina Mathieu Razafindralava Aaron Remkes Njary Rakotozandrindrainy Clara Fabienne Rasoamanamihaja Norbert Georg Schwarz Jürgen May Raphael Rakotozandrindrainy Valentina Marchese Fabio Formenti Francesca Perandin Francesca Tamarozzi Cristina Mazzi Daniela Fusco Dora Buonfrate Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
topic_facet |
Strongyloides stercoralis Strongyloidiasis Helminth Prevalence study Madagascar Ascaris lumbricoides Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Estimation of prevalence of Strongyloides stercoralis infection is required in endemic areas, in order to identify areas in need of control programmes. Data on prevalence of strongyloidiasis in Madagascar are scant. Aim of this work was to estimate prevalence of S. stercoralis in four districts of Madagascar. Methods Fecal and serum samples collected in the context of a previous study on schistosomiasis were tested with S. stercoralis real-time PCR and serology, respectively. A multiplex real-time PCR for Ascaris lumbricoides, Ancylostoma duodenalis, Necator americanus, and Trichuris trichiura was done on fecal samples collected in the areas demonstrating higher prevalence of strongyloidiasis. Comparisons between proportions were made using Fisher exact test, with false discovery rate correction used for post-hoc comparisons. A multivariable Firth logistic regression model was used to assess potential risk factors for S. stercoralis infection. Results Overall, 1775 serum samples were tested, of which 102 of 487 (20.9%) and 104 of 296 (35.2%) were serological-positive in Marovoay and in Vatomandry districts (both coastal areas), respectively, compared to 28 of 496 (5.6%) and 30 of 496 (6.1%) in Tsiroanomandidy and in Ambositra districts (both highlands), respectively (adj. p < 0.001). PCR for S. stercoralis was positive in 15 of 210 (7.1%) and in 11 of 296 (3.7%) samples from Marovoay from Vatomandry, respectively, while was negative for all samples tested in the other two districts. High prevalence of A. lumbricoides (45.9%), hookworm (44.6%) and T. trichiura (32.1%) was found in Vatomandry. In the multivariable analysis, strongyloidiasis was associated with hookworm infection. Hookworm infection was also associated with male sex and lower education level. Conclusions S. stercoralis prevalence proved higher in coastal areas compared to highlands. Different climatic conditions may explain this distribution, along with previous rounds of anthelminthics distributed in the country, which may ... |
format |
Article in Journal/Newspaper |
author |
Salvatore Scarso Rivo Andry Rakotoarivelo Jana Christina Hey Tahinamandranto Rasamoelina Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Nantenaina Mathieu Razafindralava Aaron Remkes Njary Rakotozandrindrainy Clara Fabienne Rasoamanamihaja Norbert Georg Schwarz Jürgen May Raphael Rakotozandrindrainy Valentina Marchese Fabio Formenti Francesca Perandin Francesca Tamarozzi Cristina Mazzi Daniela Fusco Dora Buonfrate |
author_facet |
Salvatore Scarso Rivo Andry Rakotoarivelo Jana Christina Hey Tahinamandranto Rasamoelina Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Nantenaina Mathieu Razafindralava Aaron Remkes Njary Rakotozandrindrainy Clara Fabienne Rasoamanamihaja Norbert Georg Schwarz Jürgen May Raphael Rakotozandrindrainy Valentina Marchese Fabio Formenti Francesca Perandin Francesca Tamarozzi Cristina Mazzi Daniela Fusco Dora Buonfrate |
author_sort |
Salvatore Scarso |
title |
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
title_short |
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
title_full |
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
title_fullStr |
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
title_full_unstemmed |
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar |
title_sort |
prevalence of strongyloides stercoralis and other helminths in four districts of madagascar |
publisher |
BMC |
publishDate |
2024 |
url |
https://doi.org/10.1186/s41182-024-00619-y https://doaj.org/article/8e2c65a2ed734a30a1b352d987aef62b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 52, Iss 1, Pp 1-8 (2024) |
op_relation |
https://doi.org/10.1186/s41182-024-00619-y https://doaj.org/toc/1349-4147 doi:10.1186/s41182-024-00619-y 1349-4147 https://doaj.org/article/8e2c65a2ed734a30a1b352d987aef62b |
op_doi |
https://doi.org/10.1186/s41182-024-00619-y |
container_title |
Tropical Medicine and Health |
container_volume |
52 |
container_issue |
1 |
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1809897018849492992 |