Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique.
BACKGROUND:In the last two decades, chikungunya virus (CHIKV) has rapidly expanded to several geographical areas, causing frequent outbreaks in sub-Saharan Africa, South East Asia, South America, and Europe. Therefore, the disease remains heavily neglected in Mozambique, and no recent study has been...
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ftdoajarticles:oai:doaj.org/article:8e207c1bedf8403e9692b9c5d6ad5e3f 2023-05-15T15:09:06+02:00 Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. Eduardo Samo Gudo Gabriela Pinto Sirkka Vene Arcildo Mandlaze Argentina Felisbela Muianga Julie Cliff Kerstin Falk 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004146 https://doaj.org/article/8e207c1bedf8403e9692b9c5d6ad5e3f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4608817?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004146 https://doaj.org/article/8e207c1bedf8403e9692b9c5d6ad5e3f PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004146 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004146 2022-12-31T00:26:14Z BACKGROUND:In the last two decades, chikungunya virus (CHIKV) has rapidly expanded to several geographical areas, causing frequent outbreaks in sub-Saharan Africa, South East Asia, South America, and Europe. Therefore, the disease remains heavily neglected in Mozambique, and no recent study has been conducted. METHODS:Between January and September 2013, acute febrile patients with no other evident cause of fever and attending a health center in a suburban area of Maputo city, Mozambique, were consecutively invited to participate. Paired acute and convalescent serum samples were requested from each participant. Convalescent samples were initially screened for anti-CHIKV IgG using a commercial indirect immunofluorescence test, and if positive, the corresponding acute sample was screened using the same test. RESULTS:Four hundred patients were enrolled. The median age of study participants was 26 years (IQR: 21-33 years) and 57.5% (224/391) were female. Paired blood samples were obtained from 209 patients, of which 26.4% (55/208) were presented anti-CHIKV IgG antibodies in the convalescent sample. Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients. CONCLUSION:The results of this study strongly suggest that CHIKV is circulating in southern Mozambique. We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 10 e0004146 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Eduardo Samo Gudo Gabriela Pinto Sirkka Vene Arcildo Mandlaze Argentina Felisbela Muianga Julie Cliff Kerstin Falk Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:In the last two decades, chikungunya virus (CHIKV) has rapidly expanded to several geographical areas, causing frequent outbreaks in sub-Saharan Africa, South East Asia, South America, and Europe. Therefore, the disease remains heavily neglected in Mozambique, and no recent study has been conducted. METHODS:Between January and September 2013, acute febrile patients with no other evident cause of fever and attending a health center in a suburban area of Maputo city, Mozambique, were consecutively invited to participate. Paired acute and convalescent serum samples were requested from each participant. Convalescent samples were initially screened for anti-CHIKV IgG using a commercial indirect immunofluorescence test, and if positive, the corresponding acute sample was screened using the same test. RESULTS:Four hundred patients were enrolled. The median age of study participants was 26 years (IQR: 21-33 years) and 57.5% (224/391) were female. Paired blood samples were obtained from 209 patients, of which 26.4% (55/208) were presented anti-CHIKV IgG antibodies in the convalescent sample. Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients. CONCLUSION:The results of this study strongly suggest that CHIKV is circulating in southern Mozambique. We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented. |
format |
Article in Journal/Newspaper |
author |
Eduardo Samo Gudo Gabriela Pinto Sirkka Vene Arcildo Mandlaze Argentina Felisbela Muianga Julie Cliff Kerstin Falk |
author_facet |
Eduardo Samo Gudo Gabriela Pinto Sirkka Vene Arcildo Mandlaze Argentina Felisbela Muianga Julie Cliff Kerstin Falk |
author_sort |
Eduardo Samo Gudo |
title |
Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
title_short |
Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
title_full |
Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
title_fullStr |
Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
title_full_unstemmed |
Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique. |
title_sort |
serological evidence of chikungunya virus among acute febrile patients in southern mozambique. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0004146 https://doaj.org/article/8e207c1bedf8403e9692b9c5d6ad5e3f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004146 (2015) |
op_relation |
http://europepmc.org/articles/PMC4608817?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004146 https://doaj.org/article/8e207c1bedf8403e9692b9c5d6ad5e3f |
op_doi |
https://doi.org/10.1371/journal.pntd.0004146 |
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PLOS Neglected Tropical Diseases |
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9 |
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10 |
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