High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya.
BACKGROUND:Chikungunya virus (CHIKV) and o'nyong nyong virus (ONNV) are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographi...
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ftdoajarticles:oai:doaj.org/article:8dff75e89f7546ac988ab9288c006cf1 2023-05-15T15:14:55+02:00 High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. A Desiree LaBeaud Tamara Banda Julie Brichard Eric M Muchiri Peter L Mungai Francis M Mutuku Erin Borland Ginny Gildengorin Sarah Pfeil Crystal Y Teng Kristin Long Mark Heise Ann M Powers Uriel Kitron Charles H King 2015-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003436 https://doaj.org/article/8dff75e89f7546ac988ab9288c006cf1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4319898?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003436 https://doaj.org/article/8dff75e89f7546ac988ab9288c006cf1 PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003436 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003436 2022-12-31T10:38:05Z BACKGROUND:Chikungunya virus (CHIKV) and o'nyong nyong virus (ONNV) are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors. METHODOLOGY:Demographic and exposure questionnaires were administered to 1,848 participants recruited from two village clusters (Milalani-Nganja and Vuga) in 2009. Sera were tested for alphavirus exposure using standardized CHIKV IgG ELISA protocols and confirmed with plaque reduction neutralization tests (PRNT). Logistic regression models were used to determine the variables associated with seropositivity. Weighted K test for global clustering of houses with alphavirus positive participants was performed for distance ranges of 50-1,000 meters, and G* statistic and kernel density mapping were used to identify locations of higher seroprevalence. PRINCIPAL FINDINGS:486 (26%) participants were seropositive by IgG ELISA. Of 443 PRNT confirmed positives, 25 samples (6%) were CHIKV+, 250 samples (56%) were ONNV+, and 168 samples (38%) had high titers for both. Age was significantly associated with seropositivity (OR 1.01 per year, 95% C.I. 1.00-1.01); however, younger adults were more likely to be seropositive than older adults. Males were less likely to be seropositive (p<0.05; OR 0.79, 95% C.I. 0.64-0.97). Adults who owned a bicycle (p<0.05; OR 1.37, 95% C.I. 1.00-1.85) or motor vehicle (p<0.05; OR 4.64, 95% C.I. 1.19-18.05) were more likely to be seropositive. Spatial analysis demonstrated hotspots of transmission within each village and clustering among local households in Milalani-Nganja, peaking at the 200-500m range. CONCLUSIONS/SIGNIFICANCE:Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor for the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 2 e0003436 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 A Desiree LaBeaud Tamara Banda Julie Brichard Eric M Muchiri Peter L Mungai Francis M Mutuku Erin Borland Ginny Gildengorin Sarah Pfeil Crystal Y Teng Kristin Long Mark Heise Ann M Powers Uriel Kitron Charles H King High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Chikungunya virus (CHIKV) and o'nyong nyong virus (ONNV) are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors. METHODOLOGY:Demographic and exposure questionnaires were administered to 1,848 participants recruited from two village clusters (Milalani-Nganja and Vuga) in 2009. Sera were tested for alphavirus exposure using standardized CHIKV IgG ELISA protocols and confirmed with plaque reduction neutralization tests (PRNT). Logistic regression models were used to determine the variables associated with seropositivity. Weighted K test for global clustering of houses with alphavirus positive participants was performed for distance ranges of 50-1,000 meters, and G* statistic and kernel density mapping were used to identify locations of higher seroprevalence. PRINCIPAL FINDINGS:486 (26%) participants were seropositive by IgG ELISA. Of 443 PRNT confirmed positives, 25 samples (6%) were CHIKV+, 250 samples (56%) were ONNV+, and 168 samples (38%) had high titers for both. Age was significantly associated with seropositivity (OR 1.01 per year, 95% C.I. 1.00-1.01); however, younger adults were more likely to be seropositive than older adults. Males were less likely to be seropositive (p<0.05; OR 0.79, 95% C.I. 0.64-0.97). Adults who owned a bicycle (p<0.05; OR 1.37, 95% C.I. 1.00-1.85) or motor vehicle (p<0.05; OR 4.64, 95% C.I. 1.19-18.05) were more likely to be seropositive. Spatial analysis demonstrated hotspots of transmission within each village and clustering among local households in Milalani-Nganja, peaking at the 200-500m range. CONCLUSIONS/SIGNIFICANCE:Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor for the ... |
format |
Article in Journal/Newspaper |
author |
A Desiree LaBeaud Tamara Banda Julie Brichard Eric M Muchiri Peter L Mungai Francis M Mutuku Erin Borland Ginny Gildengorin Sarah Pfeil Crystal Y Teng Kristin Long Mark Heise Ann M Powers Uriel Kitron Charles H King |
author_facet |
A Desiree LaBeaud Tamara Banda Julie Brichard Eric M Muchiri Peter L Mungai Francis M Mutuku Erin Borland Ginny Gildengorin Sarah Pfeil Crystal Y Teng Kristin Long Mark Heise Ann M Powers Uriel Kitron Charles H King |
author_sort |
A Desiree LaBeaud |
title |
High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
title_short |
High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
title_full |
High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
title_fullStr |
High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
title_full_unstemmed |
High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. |
title_sort |
high rates of o'nyong nyong and chikungunya virus transmission in coastal kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003436 https://doaj.org/article/8dff75e89f7546ac988ab9288c006cf1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003436 (2015) |
op_relation |
http://europepmc.org/articles/PMC4319898?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003436 https://doaj.org/article/8dff75e89f7546ac988ab9288c006cf1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003436 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
2 |
container_start_page |
e0003436 |
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1766345311924518912 |