Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C ( 1 ), 5′-methoxy-6-m...
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ftdoajarticles:oai:doaj.org/article:8dd76bb74be84d0a82b958cdf3af9149 2023-05-15T14:01:43+02:00 Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh 2022-11-01T00:00:00Z https://doi.org/10.3390/ijms232314642 https://doaj.org/article/8dd76bb74be84d0a82b958cdf3af9149 EN eng MDPI AG https://www.mdpi.com/1422-0067/23/23/14642 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms232314642 1422-0067 1661-6596 https://doaj.org/article/8dd76bb74be84d0a82b958cdf3af9149 International Journal of Molecular Sciences, Vol 23, Iss 14642, p 14642 (2022) Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Biology (General) QH301-705.5 Chemistry QD1-999 article 2022 ftdoajarticles https://doi.org/10.3390/ijms232314642 2022-12-30T19:35:50Z Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C ( 1 ), 5′-methoxy-6-methyl-biphenyl-3,4,3′-triol ( 2 ), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin ( 3 ), and alternariol monomethyl ether ( 4 ). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound 1 inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound 1 showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound 1 inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic The Antarctic International Journal of Molecular Sciences 23 23 14642 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Biology (General) QH301-705.5 Chemistry QD1-999 |
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Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Biology (General) QH301-705.5 Chemistry QD1-999 Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
topic_facet |
Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C ( 1 ), 5′-methoxy-6-methyl-biphenyl-3,4,3′-triol ( 2 ), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin ( 3 ), and alternariol monomethyl ether ( 4 ). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound 1 inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound 1 showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound 1 inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD. |
format |
Article in Journal/Newspaper |
author |
Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh |
author_facet |
Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh |
author_sort |
Linsha Dong |
title |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_short |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_full |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_fullStr |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_full_unstemmed |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_sort |
anti-inflammatory effects exerted by 14-methoxyalternate c from antarctic fungal strain pleosporales sp. sf-7343 via the regulation of nf-κb and jak2/stat3 in hacat human keratinocytes |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms232314642 https://doaj.org/article/8dd76bb74be84d0a82b958cdf3af9149 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
International Journal of Molecular Sciences, Vol 23, Iss 14642, p 14642 (2022) |
op_relation |
https://www.mdpi.com/1422-0067/23/23/14642 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms232314642 1422-0067 1661-6596 https://doaj.org/article/8dd76bb74be84d0a82b958cdf3af9149 |
op_doi |
https://doi.org/10.3390/ijms232314642 |
container_title |
International Journal of Molecular Sciences |
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23 |
container_issue |
23 |
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14642 |
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1766271762776981504 |