POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS
Aim: The objective was to describe an outbreak of bloodstream infections by Burkholderia cepacia complex (Bcc) in bone marrow transplant and hematology outpatients. Methods: On February 15, 2008 a Bcc outbreak was suspected. 24 cases were identified. Demographic and clinical data were evaluated. Env...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2014
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ftdoajarticles:oai:doaj.org/article:8dac176208cf489aaa17250d6887d18e 2024-09-09T19:27:04+00:00 POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS Icaro Boszczowski Gladys Villas Boas do Prado Mirian F. Dalben Roberto C. P. Telles Maristela Pinheiro Freire Thais Guimaraes Maura S. Oliveira Juliana F. Rosa Robson E. Soares Pedro Enrique Dorlhiac Llacer Frederico Luiz Dulley Silvia F. Costa Anna S. Levin 2014-01-01T00:00:00Z https://doi.org/10.1590/S0036-46652014000100011 https://doaj.org/article/8dac176208cf489aaa17250d6887d18e EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000100071&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000100011 https://doaj.org/article/8dac176208cf489aaa17250d6887d18e Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 1, Pp 71-76 (2014) Burkholderia cepacia complex Bloodstream infection Nosocomial infection Hematology Bone marrow transplant Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2014 ftdoajarticles https://doi.org/10.1590/S0036-46652014000100011 2024-08-05T17:49:31Z Aim: The objective was to describe an outbreak of bloodstream infections by Burkholderia cepacia complex (Bcc) in bone marrow transplant and hematology outpatients. Methods: On February 15, 2008 a Bcc outbreak was suspected. 24 cases were identified. Demographic and clinical data were evaluated. Environment and healthcare workers' (HCW) hands were cultured. Species were determined and typed. Reinforcement of hand hygiene, central venous catheter (CVC) care, infusion therapy, and maintenance of laminar flow cabinet were undertaken. 16 different HCWs had cared for the CVCs. Multi-dose heparin and saline were prepared on counter common to both units. Findings: 14 patients had B. multivorans (one patient had also B. cenopacia), six non-multivorans Bcc and one did not belong to Bcc. Clone A B. multivorans occurred in 12 patients (from Hematology); in 10 their CVC had been used on February 11/12. Environmental and HCW cultures were negative. All patients were treated with meropenem, and ceftazidime lock-therapy. Eight patients (30%) were hospitalized. No deaths occurred. After control measures (multidose vial for single patient; CVC lock with ceftazidime; cleaning of laminar flow cabinet; hand hygiene improvement; use of cabinet to store prepared medication), no new cases occurred. Conclusions: This polyclonal outbreak may be explained by a common source containing multiple species of Bcc, maybe the laminar flow cabinet common to both units. There may have been contamination by B. multivorans (clone A) of multi-dose vials. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 56 1 71 76 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Burkholderia cepacia complex Bloodstream infection Nosocomial infection Hematology Bone marrow transplant Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Burkholderia cepacia complex Bloodstream infection Nosocomial infection Hematology Bone marrow transplant Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Icaro Boszczowski Gladys Villas Boas do Prado Mirian F. Dalben Roberto C. P. Telles Maristela Pinheiro Freire Thais Guimaraes Maura S. Oliveira Juliana F. Rosa Robson E. Soares Pedro Enrique Dorlhiac Llacer Frederico Luiz Dulley Silvia F. Costa Anna S. Levin POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
topic_facet |
Burkholderia cepacia complex Bloodstream infection Nosocomial infection Hematology Bone marrow transplant Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Aim: The objective was to describe an outbreak of bloodstream infections by Burkholderia cepacia complex (Bcc) in bone marrow transplant and hematology outpatients. Methods: On February 15, 2008 a Bcc outbreak was suspected. 24 cases were identified. Demographic and clinical data were evaluated. Environment and healthcare workers' (HCW) hands were cultured. Species were determined and typed. Reinforcement of hand hygiene, central venous catheter (CVC) care, infusion therapy, and maintenance of laminar flow cabinet were undertaken. 16 different HCWs had cared for the CVCs. Multi-dose heparin and saline were prepared on counter common to both units. Findings: 14 patients had B. multivorans (one patient had also B. cenopacia), six non-multivorans Bcc and one did not belong to Bcc. Clone A B. multivorans occurred in 12 patients (from Hematology); in 10 their CVC had been used on February 11/12. Environmental and HCW cultures were negative. All patients were treated with meropenem, and ceftazidime lock-therapy. Eight patients (30%) were hospitalized. No deaths occurred. After control measures (multidose vial for single patient; CVC lock with ceftazidime; cleaning of laminar flow cabinet; hand hygiene improvement; use of cabinet to store prepared medication), no new cases occurred. Conclusions: This polyclonal outbreak may be explained by a common source containing multiple species of Bcc, maybe the laminar flow cabinet common to both units. There may have been contamination by B. multivorans (clone A) of multi-dose vials. |
format |
Article in Journal/Newspaper |
author |
Icaro Boszczowski Gladys Villas Boas do Prado Mirian F. Dalben Roberto C. P. Telles Maristela Pinheiro Freire Thais Guimaraes Maura S. Oliveira Juliana F. Rosa Robson E. Soares Pedro Enrique Dorlhiac Llacer Frederico Luiz Dulley Silvia F. Costa Anna S. Levin |
author_facet |
Icaro Boszczowski Gladys Villas Boas do Prado Mirian F. Dalben Roberto C. P. Telles Maristela Pinheiro Freire Thais Guimaraes Maura S. Oliveira Juliana F. Rosa Robson E. Soares Pedro Enrique Dorlhiac Llacer Frederico Luiz Dulley Silvia F. Costa Anna S. Levin |
author_sort |
Icaro Boszczowski |
title |
POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
title_short |
POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
title_full |
POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
title_fullStr |
POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
title_full_unstemmed |
POLYCLONAL OUTBREAK OF BLOODSTREAM INFECTIONS CAUSED BY Burkholderia cepacia COMPLEX IN HEMATOLOGY AND BONE MARROW TRANSPLANT OUTPATIENT UNITS |
title_sort |
polyclonal outbreak of bloodstream infections caused by burkholderia cepacia complex in hematology and bone marrow transplant outpatient units |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2014 |
url |
https://doi.org/10.1590/S0036-46652014000100011 https://doaj.org/article/8dac176208cf489aaa17250d6887d18e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 1, Pp 71-76 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000100071&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000100011 https://doaj.org/article/8dac176208cf489aaa17250d6887d18e |
op_doi |
https://doi.org/10.1590/S0036-46652014000100011 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
56 |
container_issue |
1 |
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71 |
op_container_end_page |
76 |
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