High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia
Objectives. The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer herders fo...
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ftdoajarticles:oai:doaj.org/article:8d8b486d5f57416ca4594b3ad3babe96 2023-05-15T15:09:59+02:00 High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia Yulia Khabarova Valentina Grigoryeva Sari Tuomisto Pekka J. Karhunen Kari Mattila Mauri Isokoski 2012-04-01T00:00:00Z https://doi.org/10.3402/ijch.v71i0.17898 https://doaj.org/article/8d8b486d5f57416ca4594b3ad3babe96 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/17898/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v71i0.17898 2242-3982 https://doaj.org/article/8d8b486d5f57416ca4594b3ad3babe96 International Journal of Circumpolar Health, Vol 71, Iss 0, Pp 1-6 (2012) adult-type hypolactasia lactase non-persistence cultural historical hypothesis nomadic Nenets genotyping Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.3402/ijch.v71i0.17898 2022-12-31T14:08:54Z Objectives. The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer herders for generations and have therefore not consumed any dairy products. The hypotheses here was that the prevalence of lactase non-persistence (−13910 C/C genotype) among Nenets people having four Nenets grandparents is high, while the prevalence among Nenets originating from ethnically mixed families is lower. Study design. The material was collected in four typical Nenets settlements in the Nenets Autonomous Okrug in Russia. One-third of the adult Nenets population were invited to answer a questionnaire and to donate buccal samples for genotyping by a doctor from the team of medical professionals who make rounds in this area. The total number of available participants was 177. Methods. Genotyping was performed with the AbiPrism system. We used the method of concordance of grandparents’ national origin to ascribe ethnicity. Results. The prevalence of adult-type hypolactasia (−13910 C/C) among Nenets who had four Nenets grandparents was found to be 90%. The figures among others reporting three, two and one grandparent of Nenets origin were 72, 60 and 28%, respectively. Conclusion. The findings are in accord with the cultural historical hypothesis. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health nenets Nenets Autonomous Okrug North-West Russia Directory of Open Access Journals: DOAJ Articles Arctic International Journal of Circumpolar Health 71 1 17898 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
adult-type hypolactasia lactase non-persistence cultural historical hypothesis nomadic Nenets genotyping Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
adult-type hypolactasia lactase non-persistence cultural historical hypothesis nomadic Nenets genotyping Arctic medicine. Tropical medicine RC955-962 Yulia Khabarova Valentina Grigoryeva Sari Tuomisto Pekka J. Karhunen Kari Mattila Mauri Isokoski High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
topic_facet |
adult-type hypolactasia lactase non-persistence cultural historical hypothesis nomadic Nenets genotyping Arctic medicine. Tropical medicine RC955-962 |
description |
Objectives. The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer herders for generations and have therefore not consumed any dairy products. The hypotheses here was that the prevalence of lactase non-persistence (−13910 C/C genotype) among Nenets people having four Nenets grandparents is high, while the prevalence among Nenets originating from ethnically mixed families is lower. Study design. The material was collected in four typical Nenets settlements in the Nenets Autonomous Okrug in Russia. One-third of the adult Nenets population were invited to answer a questionnaire and to donate buccal samples for genotyping by a doctor from the team of medical professionals who make rounds in this area. The total number of available participants was 177. Methods. Genotyping was performed with the AbiPrism system. We used the method of concordance of grandparents’ national origin to ascribe ethnicity. Results. The prevalence of adult-type hypolactasia (−13910 C/C) among Nenets who had four Nenets grandparents was found to be 90%. The figures among others reporting three, two and one grandparent of Nenets origin were 72, 60 and 28%, respectively. Conclusion. The findings are in accord with the cultural historical hypothesis. |
format |
Article in Journal/Newspaper |
author |
Yulia Khabarova Valentina Grigoryeva Sari Tuomisto Pekka J. Karhunen Kari Mattila Mauri Isokoski |
author_facet |
Yulia Khabarova Valentina Grigoryeva Sari Tuomisto Pekka J. Karhunen Kari Mattila Mauri Isokoski |
author_sort |
Yulia Khabarova |
title |
High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
title_short |
High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
title_full |
High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
title_fullStr |
High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
title_full_unstemmed |
High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia |
title_sort |
high prevalence of lactase non-persistence among indigenous nomadic nenets, north-west russia |
publisher |
Taylor & Francis Group |
publishDate |
2012 |
url |
https://doi.org/10.3402/ijch.v71i0.17898 https://doaj.org/article/8d8b486d5f57416ca4594b3ad3babe96 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health nenets Nenets Autonomous Okrug North-West Russia |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health nenets Nenets Autonomous Okrug North-West Russia |
op_source |
International Journal of Circumpolar Health, Vol 71, Iss 0, Pp 1-6 (2012) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/17898/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v71i0.17898 2242-3982 https://doaj.org/article/8d8b486d5f57416ca4594b3ad3babe96 |
op_doi |
https://doi.org/10.3402/ijch.v71i0.17898 |
container_title |
International Journal of Circumpolar Health |
container_volume |
71 |
container_issue |
1 |
container_start_page |
17898 |
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1766341063984807936 |