Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness
The breeds of domestic dog, Canis lupus familiaris, display a range of coat types with variation in color, texture, length, curl, and growth pattern. One trait of interest is that of partial or full hairlessness, which is found in a small number of breeds. While the standard for some breeds, such as...
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ftdoajarticles:oai:doaj.org/article:8d6f59317e084af1ae599f1582df4195 2023-05-15T15:49:47+02:00 Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness Heidi G. Parker D. Thad Whitaker Alexander C. Harris Elaine A. Ostrander 2020-01-01T00:00:00Z https://doi.org/10.1534/g3.119.400885 https://doaj.org/article/8d6f59317e084af1ae599f1582df4195 EN eng Oxford University Press http://g3journal.org/lookup/doi/10.1534/g3.119.400885 https://doaj.org/toc/2160-1836 2160-1836 doi:10.1534/g3.119.400885 https://doaj.org/article/8d6f59317e084af1ae599f1582df4195 G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 293-297 (2020) canis lupus familiaris fur hair dog genetics QH426-470 article 2020 ftdoajarticles https://doi.org/10.1534/g3.119.400885 2022-12-31T05:32:38Z The breeds of domestic dog, Canis lupus familiaris, display a range of coat types with variation in color, texture, length, curl, and growth pattern. One trait of interest is that of partial or full hairlessness, which is found in a small number of breeds. While the standard for some breeds, such as the Xoloitzcuintli, requires sparse hair on their extremities, others are entirely bald, including the American Hairless Terrier. We identified a small, rare family of Scottish Deerhounds in which coated parents produced a mixed litter of coated and hairless offspring. To identify the underlying variant, we performed whole genome sequencing of the dam and five offspring, comparing single nucleotide polymorphisms and small insertions/deletions against an established catalog of 91 million canine variants. Of 325 homozygous alternative alleles found in both hairless dogs, 56 displayed the expected pattern of segregation and only a single, high impact variant within a coding region was observed: a single base pair insertion in exon two of SGK3 leading to a potential frameshift, thus verifying recently published findings. In addition, we observed that gene expression levels between coated and hairless dogs are similar, suggesting a mechanism other than non-sense mediated decay is responsible for the phenotype. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Curl ENVELOPE(-63.071,-63.071,-70.797,-70.797) G3 Genes|Genomes|Genetics 10 1 293 297 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
canis lupus familiaris fur hair dog genetics QH426-470 |
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canis lupus familiaris fur hair dog genetics QH426-470 Heidi G. Parker D. Thad Whitaker Alexander C. Harris Elaine A. Ostrander Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
topic_facet |
canis lupus familiaris fur hair dog genetics QH426-470 |
description |
The breeds of domestic dog, Canis lupus familiaris, display a range of coat types with variation in color, texture, length, curl, and growth pattern. One trait of interest is that of partial or full hairlessness, which is found in a small number of breeds. While the standard for some breeds, such as the Xoloitzcuintli, requires sparse hair on their extremities, others are entirely bald, including the American Hairless Terrier. We identified a small, rare family of Scottish Deerhounds in which coated parents produced a mixed litter of coated and hairless offspring. To identify the underlying variant, we performed whole genome sequencing of the dam and five offspring, comparing single nucleotide polymorphisms and small insertions/deletions against an established catalog of 91 million canine variants. Of 325 homozygous alternative alleles found in both hairless dogs, 56 displayed the expected pattern of segregation and only a single, high impact variant within a coding region was observed: a single base pair insertion in exon two of SGK3 leading to a potential frameshift, thus verifying recently published findings. In addition, we observed that gene expression levels between coated and hairless dogs are similar, suggesting a mechanism other than non-sense mediated decay is responsible for the phenotype. |
format |
Article in Journal/Newspaper |
author |
Heidi G. Parker D. Thad Whitaker Alexander C. Harris Elaine A. Ostrander |
author_facet |
Heidi G. Parker D. Thad Whitaker Alexander C. Harris Elaine A. Ostrander |
author_sort |
Heidi G. Parker |
title |
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
title_short |
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
title_full |
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
title_fullStr |
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
title_full_unstemmed |
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness |
title_sort |
whole genome analysis of a single scottish deerhound dog family provides independent corroboration that a sgk3 coding variant leads to hairlessness |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
https://doi.org/10.1534/g3.119.400885 https://doaj.org/article/8d6f59317e084af1ae599f1582df4195 |
long_lat |
ENVELOPE(-63.071,-63.071,-70.797,-70.797) |
geographic |
Curl |
geographic_facet |
Curl |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 293-297 (2020) |
op_relation |
http://g3journal.org/lookup/doi/10.1534/g3.119.400885 https://doaj.org/toc/2160-1836 2160-1836 doi:10.1534/g3.119.400885 https://doaj.org/article/8d6f59317e084af1ae599f1582df4195 |
op_doi |
https://doi.org/10.1534/g3.119.400885 |
container_title |
G3 Genes|Genomes|Genetics |
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10 |
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293 |
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