Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019
Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findin...
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ftdoajarticles:oai:doaj.org/article:8d6db939b4a844528e775d8214312e1d 2023-05-15T15:10:28+02:00 Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 Narges Amani Hamedani Majid Pirestani Abdolhossein Dalimi 2022-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.364002 https://doaj.org/article/8d6db939b4a844528e775d8214312e1d EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=558;epage=567;aulast=Hamedani https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.364002 https://doaj.org/article/8d6db939b4a844528e775d8214312e1d Asian Pacific Journal of Tropical Medicine, Vol 15, Iss 12, Pp 558-567 (2022) human cystic echinococcosis clinical features genotype tehran Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.4103/1995-7645.364002 2023-01-15T01:25:47Z Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findings, and laboratory data were collected. Formalin-fixed, paraffin-embedded and fresh tissue samples of 175 cystic echinococcosis patients were evaluated for molecular characterization. The samples’ isolated DNA was used to amplify cytochrome c oxidase I and NADH dehydrogenase subunit I genes. Also, the morphological features of fresh samples were examined. Results: In total, 175 patients with a mean age of 45 (9-98) years were admitted to Tehran’s hospitals diagnosed with cystic echinococcosis. Moreover, the highest (26.9%) and the lowest (2.9%) prevalence of cystic echinococcosis cases were in the 16-30 and 1-15 years range, respectively. Male/female ratio was 0.96 (49.1% vs. 50.9%). The liver was affected in 92 patients (52.6%), and two or more organs were infected in 7 patients (4.0%). The cysts’ diameter varied from 1 to 25 cm, and 96.0% of the patients had a single hydatid cyst. All patients underwent radical surgery and the PAIR technique was applied for all cases. No significant difference was observed between the protoscolex hooks of pulmonary and hepatic cysts. G1-G3 had the highest percentage (99.4%) over other identified G6 genotypes (0.6%). Conclusions: The sheep-dog cycle plays an important role in transmitting the human cystic echinococcosis infection in Tehran. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 15 12 558 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
human cystic echinococcosis clinical features genotype tehran Arctic medicine. Tropical medicine RC955-962 |
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human cystic echinococcosis clinical features genotype tehran Arctic medicine. Tropical medicine RC955-962 Narges Amani Hamedani Majid Pirestani Abdolhossein Dalimi Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
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human cystic echinococcosis clinical features genotype tehran Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findings, and laboratory data were collected. Formalin-fixed, paraffin-embedded and fresh tissue samples of 175 cystic echinococcosis patients were evaluated for molecular characterization. The samples’ isolated DNA was used to amplify cytochrome c oxidase I and NADH dehydrogenase subunit I genes. Also, the morphological features of fresh samples were examined. Results: In total, 175 patients with a mean age of 45 (9-98) years were admitted to Tehran’s hospitals diagnosed with cystic echinococcosis. Moreover, the highest (26.9%) and the lowest (2.9%) prevalence of cystic echinococcosis cases were in the 16-30 and 1-15 years range, respectively. Male/female ratio was 0.96 (49.1% vs. 50.9%). The liver was affected in 92 patients (52.6%), and two or more organs were infected in 7 patients (4.0%). The cysts’ diameter varied from 1 to 25 cm, and 96.0% of the patients had a single hydatid cyst. All patients underwent radical surgery and the PAIR technique was applied for all cases. No significant difference was observed between the protoscolex hooks of pulmonary and hepatic cysts. G1-G3 had the highest percentage (99.4%) over other identified G6 genotypes (0.6%). Conclusions: The sheep-dog cycle plays an important role in transmitting the human cystic echinococcosis infection in Tehran. |
format |
Article in Journal/Newspaper |
author |
Narges Amani Hamedani Majid Pirestani Abdolhossein Dalimi |
author_facet |
Narges Amani Hamedani Majid Pirestani Abdolhossein Dalimi |
author_sort |
Narges Amani Hamedani |
title |
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
title_short |
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
title_full |
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
title_fullStr |
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
title_full_unstemmed |
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 |
title_sort |
clinical and molecular features of human cystic echinococcosis in tehran, iran, 2011-2019 |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/1995-7645.364002 https://doaj.org/article/8d6db939b4a844528e775d8214312e1d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 15, Iss 12, Pp 558-567 (2022) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=558;epage=567;aulast=Hamedani https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.364002 https://doaj.org/article/8d6db939b4a844528e775d8214312e1d |
op_doi |
https://doi.org/10.4103/1995-7645.364002 |
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Asian Pacific Journal of Tropical Medicine |
container_volume |
15 |
container_issue |
12 |
container_start_page |
558 |
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