HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population
Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients...
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ftdoajarticles:oai:doaj.org/article:8d5fd170b0184bcd853e30fc5dc963b2 2024-09-09T19:26:12+00:00 HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population Liciana Xavier Eurico de Alencar Ulisses de Mendonça Braga-Neto Eduardo José Moura do Nascimento Marli Tenório Cordeiro Ana Maria Silva Carlos Alexandre Antunes de Brito Maria da Paz Carvalho da Silva Laura Helena Vega Gonzales Gil Silvia Maria Lucena Montenegro Ernesto Torres de Azevedo Marques 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/648475 https://doaj.org/article/8d5fd170b0184bcd853e30fc5dc963b2 EN eng Wiley http://dx.doi.org/10.1155/2013/648475 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/648475 https://doaj.org/article/8d5fd170b0184bcd853e30fc5dc963b2 Journal of Tropical Medicine, Vol 2013 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1155/2013/648475 2024-08-05T17:48:45Z Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher’s association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97–4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0–0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0–0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B*44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B*07 supertype alleles and DR*13 might be involved in cross-dengue serotype immunity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2013 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Liciana Xavier Eurico de Alencar Ulisses de Mendonça Braga-Neto Eduardo José Moura do Nascimento Marli Tenório Cordeiro Ana Maria Silva Carlos Alexandre Antunes de Brito Maria da Paz Carvalho da Silva Laura Helena Vega Gonzales Gil Silvia Maria Lucena Montenegro Ernesto Torres de Azevedo Marques HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher’s association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97–4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0–0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0–0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B*44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B*07 supertype alleles and DR*13 might be involved in cross-dengue serotype immunity. |
format |
Article in Journal/Newspaper |
author |
Liciana Xavier Eurico de Alencar Ulisses de Mendonça Braga-Neto Eduardo José Moura do Nascimento Marli Tenório Cordeiro Ana Maria Silva Carlos Alexandre Antunes de Brito Maria da Paz Carvalho da Silva Laura Helena Vega Gonzales Gil Silvia Maria Lucena Montenegro Ernesto Torres de Azevedo Marques |
author_facet |
Liciana Xavier Eurico de Alencar Ulisses de Mendonça Braga-Neto Eduardo José Moura do Nascimento Marli Tenório Cordeiro Ana Maria Silva Carlos Alexandre Antunes de Brito Maria da Paz Carvalho da Silva Laura Helena Vega Gonzales Gil Silvia Maria Lucena Montenegro Ernesto Torres de Azevedo Marques |
author_sort |
Liciana Xavier Eurico de Alencar |
title |
HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
title_short |
HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
title_full |
HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
title_fullStr |
HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
title_full_unstemmed |
HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
title_sort |
hla-b*44 is associated with dengue severity caused by denv-3 in a brazilian population |
publisher |
Wiley |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/648475 https://doaj.org/article/8d5fd170b0184bcd853e30fc5dc963b2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/648475 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/648475 https://doaj.org/article/8d5fd170b0184bcd853e30fc5dc963b2 |
op_doi |
https://doi.org/10.1155/2013/648475 |
container_title |
Journal of Tropical Medicine |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1809895864243585024 |