Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India.
Brucellosis is endemic in the bovine population in India and causes a loss of US$ 3·4 billion to the livestock industry besides having a significant human health impact.We developed a stochastic simulation model to estimate the impact of three alternative vaccination strategies on the prevalence of...
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ftdoajarticles:oai:doaj.org/article:8d536b3a565541d4a79fb3451460f5da 2023-05-15T15:14:14+02:00 Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. Balbir B Singh Polychronis Kostoulas Jatinder P S Gill Navneet K Dhand 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006488 https://doaj.org/article/8d536b3a565541d4a79fb3451460f5da EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5963803?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006488 https://doaj.org/article/8d536b3a565541d4a79fb3451460f5da PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006488 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006488 2022-12-31T02:16:11Z Brucellosis is endemic in the bovine population in India and causes a loss of US$ 3·4 billion to the livestock industry besides having a significant human health impact.We developed a stochastic simulation model to estimate the impact of three alternative vaccination strategies on the prevalence of Brucella infection in the bovine populations in India for the next two decades: (a) annual mass vaccination only for the replacement calves and (b) vaccination of both the adult and young population at the beginning of the program followed by an annual vaccination of the replacement calves and, (c) annual mass vaccination of replacements for a decade followed by a decade of a test and slaughter strategy.For all interventions, our results indicate that the prevalence of Brucella infection will drop below 2% in cattle and, below 3% in buffalo after 20 years of the implementation of a disease control program. For cattle, the Net Present Value (NPV) was found to be US $ 4·16 billion for intervention (a), US $ 8·31 billion for intervention (b) and, US $ 4·26 for intervention (c). For buffalo, the corresponding NPVs were US $ 8·77 billion, US $ 13·42 and, US $ 7·66, respectively. The benefit cost ratio (BCR) for the first, second and the third intervention for cattle were 7·98, 10·62 and, 3·16, respectively. Corresponding BCR estimates for buffalo were 17·81, 21·27 and, 3·79, respectively.These results suggest that all interventions will be cost-effective with the intervention (b), i.e. the vaccination of replacements with mass vaccination at the beginning of the program, being the most cost-effective choice. Further, sensitivity analysis revealed that all interventions will be cost-effective even at the 50% of the current prevalence estimates. The results advocate for the implementation of a disease control program for brucellosis in India. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic Slaughter ENVELOPE(-85.633,-85.633,-78.617,-78.617) PLOS Neglected Tropical Diseases 12 5 e0006488 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Balbir B Singh Polychronis Kostoulas Jatinder P S Gill Navneet K Dhand Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Brucellosis is endemic in the bovine population in India and causes a loss of US$ 3·4 billion to the livestock industry besides having a significant human health impact.We developed a stochastic simulation model to estimate the impact of three alternative vaccination strategies on the prevalence of Brucella infection in the bovine populations in India for the next two decades: (a) annual mass vaccination only for the replacement calves and (b) vaccination of both the adult and young population at the beginning of the program followed by an annual vaccination of the replacement calves and, (c) annual mass vaccination of replacements for a decade followed by a decade of a test and slaughter strategy.For all interventions, our results indicate that the prevalence of Brucella infection will drop below 2% in cattle and, below 3% in buffalo after 20 years of the implementation of a disease control program. For cattle, the Net Present Value (NPV) was found to be US $ 4·16 billion for intervention (a), US $ 8·31 billion for intervention (b) and, US $ 4·26 for intervention (c). For buffalo, the corresponding NPVs were US $ 8·77 billion, US $ 13·42 and, US $ 7·66, respectively. The benefit cost ratio (BCR) for the first, second and the third intervention for cattle were 7·98, 10·62 and, 3·16, respectively. Corresponding BCR estimates for buffalo were 17·81, 21·27 and, 3·79, respectively.These results suggest that all interventions will be cost-effective with the intervention (b), i.e. the vaccination of replacements with mass vaccination at the beginning of the program, being the most cost-effective choice. Further, sensitivity analysis revealed that all interventions will be cost-effective even at the 50% of the current prevalence estimates. The results advocate for the implementation of a disease control program for brucellosis in India. |
format |
Article in Journal/Newspaper |
author |
Balbir B Singh Polychronis Kostoulas Jatinder P S Gill Navneet K Dhand |
author_facet |
Balbir B Singh Polychronis Kostoulas Jatinder P S Gill Navneet K Dhand |
author_sort |
Balbir B Singh |
title |
Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
title_short |
Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
title_full |
Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
title_fullStr |
Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
title_full_unstemmed |
Cost-benefit analysis of intervention policies for prevention and control of brucellosis in India. |
title_sort |
cost-benefit analysis of intervention policies for prevention and control of brucellosis in india. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006488 https://doaj.org/article/8d536b3a565541d4a79fb3451460f5da |
long_lat |
ENVELOPE(-85.633,-85.633,-78.617,-78.617) |
geographic |
Arctic Slaughter |
geographic_facet |
Arctic Slaughter |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006488 (2018) |
op_relation |
http://europepmc.org/articles/PMC5963803?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006488 https://doaj.org/article/8d536b3a565541d4a79fb3451460f5da |
op_doi |
https://doi.org/10.1371/journal.pntd.0006488 |
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PLOS Neglected Tropical Diseases |
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12 |
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5 |
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e0006488 |
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