Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure
ABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), an...
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ftdoajarticles:oai:doaj.org/article:8d4c4b75de82496e939e5bcdaed8acf1 2023-05-15T15:05:26+02:00 Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi https://doi.org/10.1590/0037-8682-0461-2016 https://doaj.org/article/8d4c4b75de82496e939e5bcdaed8acf1 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100075&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0461-2016 https://doaj.org/article/8d4c4b75de82496e939e5bcdaed8acf1 Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 75-79 Antiseptics Susceptibility Candida dubliniensis Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0461-2016 2022-12-30T23:24:30Z ABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. RESULTS: Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. CONCLUSIONS: The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 1 75 79 |
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Antiseptics Susceptibility Candida dubliniensis Arctic medicine. Tropical medicine RC955-962 |
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Antiseptics Susceptibility Candida dubliniensis Arctic medicine. Tropical medicine RC955-962 Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
topic_facet |
Antiseptics Susceptibility Candida dubliniensis Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. RESULTS: Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. CONCLUSIONS: The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested. |
format |
Article in Journal/Newspaper |
author |
Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi |
author_facet |
Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi |
author_sort |
Cássia Franco Reginato |
title |
Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
title_short |
Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
title_full |
Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
title_fullStr |
Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
title_full_unstemmed |
Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
title_sort |
antifungal activity of synthetic antiseptics and natural compounds against candida dubliniensis before and after in vitro fluconazole exposure |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0461-2016 https://doaj.org/article/8d4c4b75de82496e939e5bcdaed8acf1 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
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Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 75-79 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100075&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0461-2016 https://doaj.org/article/8d4c4b75de82496e939e5bcdaed8acf1 |
op_doi |
https://doi.org/10.1590/0037-8682-0461-2016 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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50 |
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75 |
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79 |
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