Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis
OBJECTIVE: To identify and summarize randomized clinical trials (RCTs) that assessed the effectiveness of chemoprophylaxis to prevent leprosy in contacts of patients newly diagnosed with the disease. METHODS: All studies were extracted from Medline (PubMed 1966 to November 2008), the Cochrane Contro...
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Pan American Health Organization
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ftdoajarticles:oai:doaj.org/article:8d31031f3a1f4681a50ab293a7d6c55e 2023-05-15T15:17:09+02:00 Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis Ludovic Reveiz Jefferson A. Buendía Diana Téllez 2009-10-01T00:00:00Z https://doaj.org/article/8d31031f3a1f4681a50ab293a7d6c55e EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009001000009 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/8d31031f3a1f4681a50ab293a7d6c55e Revista Panamericana de Salud Pública, Vol 26, Iss 4, Pp 341-349 (2009) Lepra quimioprevención trazado de contacto ensayos clínicos aleatorios metanálisis Leprosy chemoprophylaxis contact tracing randomized clinical trials meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles 2022-12-31T06:25:39Z OBJECTIVE: To identify and summarize randomized clinical trials (RCTs) that assessed the effectiveness of chemoprophylaxis to prevent leprosy in contacts of patients newly diagnosed with the disease. METHODS: All studies were extracted from Medline (PubMed 1966 to November 2008), the Cochrane Controlled Trials Register (number 3 2008), LILACS (1982 to November 2008), and Scirus (November 2008). Manual searches and searches of crossed references of assessed articles were also done. RCTs' risk of bias was assessed according to the methodology proposed by the Cochrane Collaboration. The main outcome measure was diagnosis of leprosy (secondary cases) in contacts of patients with the disease (primary cases). RESULTS: The search identified 320 references, from which 7 RCTs with a total of 66 311 participants were included and evaluated. The combined results from the RCTs favored chemoprophylaxis to placebo with 2-4 years of follow-up (6 RCTs, 66 107 participants, relative risk (RR) 0.59, 95% confidence interval (CI) 0.50-0.70, I² = 0 (I² describes percent total variation across studies caused by heterogeneity)). Single-dose rifampicin (21 711 participants, RR 0.43, 95% CI 0.28-0.67, number needed to treat 285), dapsone once or twice weekly for at least 2 years (3 RCTs, 43 137 participants, RR 0.60, 95% CI 0.48-0.76, I² = 0), and acedapsone every 10 weeks for 7 months (2 RCTs, 1 259 participants, RR 0.49, 95% CI 0.33-0.72, I² = 0) were significantly superior to placebo in preventing secondary cases of leprosy. CONCLUSION: Chemoprophylaxis is effective in lowering the incidence of leprosy in contacts of patients diagnosed with the disease. OBJETIVO: Identificar y hacer un compendio de los ensayos clínicos aleatorizados (ECA) que evaluaron la eficacia de la quimioprofilaxis para prevenir la lepra en los contactos de pacientes con diagnóstico reciente de esa enfermedad. MÉTODOS: Se extrajeron todos los estudios de Medline (PubMed, de 1966 a noviembre de 2008), el Registro de Ensayos Controlados de Cochrane (No. 3 de ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Lepra quimioprevención trazado de contacto ensayos clínicos aleatorios metanálisis Leprosy chemoprophylaxis contact tracing randomized clinical trials meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Lepra quimioprevención trazado de contacto ensayos clínicos aleatorios metanálisis Leprosy chemoprophylaxis contact tracing randomized clinical trials meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ludovic Reveiz Jefferson A. Buendía Diana Téllez Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
topic_facet |
Lepra quimioprevención trazado de contacto ensayos clínicos aleatorios metanálisis Leprosy chemoprophylaxis contact tracing randomized clinical trials meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To identify and summarize randomized clinical trials (RCTs) that assessed the effectiveness of chemoprophylaxis to prevent leprosy in contacts of patients newly diagnosed with the disease. METHODS: All studies were extracted from Medline (PubMed 1966 to November 2008), the Cochrane Controlled Trials Register (number 3 2008), LILACS (1982 to November 2008), and Scirus (November 2008). Manual searches and searches of crossed references of assessed articles were also done. RCTs' risk of bias was assessed according to the methodology proposed by the Cochrane Collaboration. The main outcome measure was diagnosis of leprosy (secondary cases) in contacts of patients with the disease (primary cases). RESULTS: The search identified 320 references, from which 7 RCTs with a total of 66 311 participants were included and evaluated. The combined results from the RCTs favored chemoprophylaxis to placebo with 2-4 years of follow-up (6 RCTs, 66 107 participants, relative risk (RR) 0.59, 95% confidence interval (CI) 0.50-0.70, I² = 0 (I² describes percent total variation across studies caused by heterogeneity)). Single-dose rifampicin (21 711 participants, RR 0.43, 95% CI 0.28-0.67, number needed to treat 285), dapsone once or twice weekly for at least 2 years (3 RCTs, 43 137 participants, RR 0.60, 95% CI 0.48-0.76, I² = 0), and acedapsone every 10 weeks for 7 months (2 RCTs, 1 259 participants, RR 0.49, 95% CI 0.33-0.72, I² = 0) were significantly superior to placebo in preventing secondary cases of leprosy. CONCLUSION: Chemoprophylaxis is effective in lowering the incidence of leprosy in contacts of patients diagnosed with the disease. OBJETIVO: Identificar y hacer un compendio de los ensayos clínicos aleatorizados (ECA) que evaluaron la eficacia de la quimioprofilaxis para prevenir la lepra en los contactos de pacientes con diagnóstico reciente de esa enfermedad. MÉTODOS: Se extrajeron todos los estudios de Medline (PubMed, de 1966 a noviembre de 2008), el Registro de Ensayos Controlados de Cochrane (No. 3 de ... |
format |
Article in Journal/Newspaper |
author |
Ludovic Reveiz Jefferson A. Buendía Diana Téllez |
author_facet |
Ludovic Reveiz Jefferson A. Buendía Diana Téllez |
author_sort |
Ludovic Reveiz |
title |
Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
title_short |
Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
title_full |
Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
title_fullStr |
Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
title_full_unstemmed |
Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis Quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
title_sort |
chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis quimioprofilaxis en contactos de pacientes con lepra: revisión sistemática y metanálisis |
publisher |
Pan American Health Organization |
publishDate |
2009 |
url |
https://doaj.org/article/8d31031f3a1f4681a50ab293a7d6c55e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 26, Iss 4, Pp 341-349 (2009) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009001000009 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/8d31031f3a1f4681a50ab293a7d6c55e |
_version_ |
1766347411937034240 |