Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis.
Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phospho...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0005615 https://doaj.org/article/8ca6b36420ea42a9a1de557c5ab5520c |
id |
ftdoajarticles:oai:doaj.org/article:8ca6b36420ea42a9a1de557c5ab5520c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:8ca6b36420ea42a9a1de557c5ab5520c 2023-05-15T15:06:05+02:00 Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. Patrícia A E Abreu Antonio C Seguro Daniele Canale Ana Maria G da Silva Larissa do R B Matos Tatiane B Gotti Denize Monaris Denise A de Jesus Sílvio A Vasconcellos Thales de Brito Antonio J B Magaldi 2017-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005615 https://doaj.org/article/8ca6b36420ea42a9a1de557c5ab5520c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5444857?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005615 https://doaj.org/article/8ca6b36420ea42a9a1de557c5ab5520c PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005615 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005615 2022-12-31T16:24:22Z Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 5 e0005615 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patrícia A E Abreu Antonio C Seguro Daniele Canale Ana Maria G da Silva Larissa do R B Matos Tatiane B Gotti Denize Monaris Denise A de Jesus Sílvio A Vasconcellos Thales de Brito Antonio J B Magaldi Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality. |
format |
Article in Journal/Newspaper |
author |
Patrícia A E Abreu Antonio C Seguro Daniele Canale Ana Maria G da Silva Larissa do R B Matos Tatiane B Gotti Denize Monaris Denise A de Jesus Sílvio A Vasconcellos Thales de Brito Antonio J B Magaldi |
author_facet |
Patrícia A E Abreu Antonio C Seguro Daniele Canale Ana Maria G da Silva Larissa do R B Matos Tatiane B Gotti Denize Monaris Denise A de Jesus Sílvio A Vasconcellos Thales de Brito Antonio J B Magaldi |
author_sort |
Patrícia A E Abreu |
title |
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
title_short |
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
title_full |
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
title_fullStr |
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
title_full_unstemmed |
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
title_sort |
lp25 membrane protein from pathogenic leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005615 https://doaj.org/article/8ca6b36420ea42a9a1de557c5ab5520c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005615 (2017) |
op_relation |
http://europepmc.org/articles/PMC5444857?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005615 https://doaj.org/article/8ca6b36420ea42a9a1de557c5ab5520c |
op_doi |
https://doi.org/10.1371/journal.pntd.0005615 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
5 |
container_start_page |
e0005615 |
_version_ |
1766337739328847872 |