Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.
BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0003647 https://doaj.org/article/8c89374d797643288c9a29ece433f721 |
id |
ftdoajarticles:oai:doaj.org/article:8c89374d797643288c9a29ece433f721 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:8c89374d797643288c9a29ece433f721 2023-05-15T15:10:29+02:00 Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. Justin S Antony Olusola Ojurongbe Peter G Kremsner Thirumalaisamy P Velavan 2015-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003647 https://doaj.org/article/8c89374d797643288c9a29ece433f721 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4373859?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003647 https://doaj.org/article/8c89374d797643288c9a29ece433f721 PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003647 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003647 2022-12-31T05:33:52Z BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose. METHODOLOGY/PRINCIPAL FINDINGS:We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and investigated the contribution of CL-K1 deficiency and of COLEC11 polymorphisms to infection phenotype. Higher CL-K1 serum levels were associated with decreased risk of schistosome infection (P corr = 0.0004). CL-K1 serum levels were differentially distributed between the COLEC11 genotypes and haplotypes observed. The non-synonymous variant p.R216H was associated with the occurrence of schistosomiasis (OR = 0.44, 95%CI = 0.22-0.72, P corr = 0.0004). The reconstructed COLEC11*TCCA haplotypes were associated with higher CL-K1 serum levels (P = 0.002) and with decreased schistosomiasis (OR = 0.38, 95%CI = 0.23-0.63, P corr = 0.0001). CONCLUSIONS:In agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 3 e0003647 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Justin S Antony Olusola Ojurongbe Peter G Kremsner Thirumalaisamy P Velavan Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose. METHODOLOGY/PRINCIPAL FINDINGS:We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and investigated the contribution of CL-K1 deficiency and of COLEC11 polymorphisms to infection phenotype. Higher CL-K1 serum levels were associated with decreased risk of schistosome infection (P corr = 0.0004). CL-K1 serum levels were differentially distributed between the COLEC11 genotypes and haplotypes observed. The non-synonymous variant p.R216H was associated with the occurrence of schistosomiasis (OR = 0.44, 95%CI = 0.22-0.72, P corr = 0.0004). The reconstructed COLEC11*TCCA haplotypes were associated with higher CL-K1 serum levels (P = 0.002) and with decreased schistosomiasis (OR = 0.38, 95%CI = 0.23-0.63, P corr = 0.0001). CONCLUSIONS:In agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations. |
format |
Article in Journal/Newspaper |
author |
Justin S Antony Olusola Ojurongbe Peter G Kremsner Thirumalaisamy P Velavan |
author_facet |
Justin S Antony Olusola Ojurongbe Peter G Kremsner Thirumalaisamy P Velavan |
author_sort |
Justin S Antony |
title |
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
title_short |
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
title_full |
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
title_fullStr |
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
title_full_unstemmed |
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. |
title_sort |
lectin complement protein collectin 11 (cl-k1) and susceptibility to urinary schistosomiasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003647 https://doaj.org/article/8c89374d797643288c9a29ece433f721 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003647 (2015) |
op_relation |
http://europepmc.org/articles/PMC4373859?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003647 https://doaj.org/article/8c89374d797643288c9a29ece433f721 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003647 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
3 |
container_start_page |
e0003647 |
_version_ |
1766341505964834816 |