Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study.
BACKGROUND: Elevated platelet count is associated with risk of venous thromboembolism in cancer patients initiating chemotherapy. It is not known whether this risk by platelet count is causal or merely reflects the malignant disease. We investigated whether pre-cancer platelet count alone or togethe...
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ftdoajarticles:oai:doaj.org/article:8c4fdfcf7a0647de811aee6df170a8d0 2023-05-15T18:34:32+02:00 Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. Hilde Jensvoll Kristine Blix Sigrid K Brækkan John-Bjarne Hansen 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0092011 https://doaj.org/article/8c4fdfcf7a0647de811aee6df170a8d0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3958406?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0092011 https://doaj.org/article/8c4fdfcf7a0647de811aee6df170a8d0 PLoS ONE, Vol 9, Iss 3, p e92011 (2014) Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1371/journal.pone.0092011 2022-12-31T04:15:19Z BACKGROUND: Elevated platelet count is associated with risk of venous thromboembolism in cancer patients initiating chemotherapy. It is not known whether this risk by platelet count is causal or merely reflects the malignant disease. We investigated whether pre-cancer platelet count alone or together with high leukocyte count was associated with risk of venous thromboembolism in subjects who did and did not develop cancer during follow-up in a population-based cohort study. METHODS: Platelet count and other baseline characteristics were measured in 25160 initially cancer-free subjects who participated in the Tromsø Study in 1994-1995. Incident cancer and symptomatic venous thromboembolism events were registered up to December 31st, 2009. Multivariable Cox regression models were used to calculate hazard ratio for venous thromboembolism across categories of platelet count (<40th, 40-80th, and >80th percentile) with 95% confidence interval. RESULTS: During follow-up, 2082 subjects were diagnosed with cancer. Platelet count was measured on average 8.3 years before the cancer diagnosis. There were 129 venous thromboembolism events in the cancer cohort (13.5 per 1000 person-years) and 377 in the non-cancer cohort (1.2 per 1000 person-years). In cancer patients, pre-cancer platelet count above the 80th percentile (≥295×10(9)/L) was associated with a 2-fold higher risk of venous thromboembolism (Hazard ratio: 1.98, 95% confidence interval 1.21-3.23) compared to platelet count below the 40th percentile (<235×10(9)/L). Concomitant high platelet and leukocyte counts showed a synergistic effect on the VTE risk. In cancer-free subjects, no association was found. COMMENT: In conclusion, pre-cancer platelet count was associated with risk of symptomatic venous thromboembolism in cancer patients, but not in cancer-free subjects. Our findings suggest that platelet count and platelet-leukocyte interactions may play a role in the pathogenesis of cancer-related venous thromboembolism. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø PLoS ONE 9 3 e92011 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Medicine R Science Q |
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Medicine R Science Q Hilde Jensvoll Kristine Blix Sigrid K Brækkan John-Bjarne Hansen Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
topic_facet |
Medicine R Science Q |
description |
BACKGROUND: Elevated platelet count is associated with risk of venous thromboembolism in cancer patients initiating chemotherapy. It is not known whether this risk by platelet count is causal or merely reflects the malignant disease. We investigated whether pre-cancer platelet count alone or together with high leukocyte count was associated with risk of venous thromboembolism in subjects who did and did not develop cancer during follow-up in a population-based cohort study. METHODS: Platelet count and other baseline characteristics were measured in 25160 initially cancer-free subjects who participated in the Tromsø Study in 1994-1995. Incident cancer and symptomatic venous thromboembolism events were registered up to December 31st, 2009. Multivariable Cox regression models were used to calculate hazard ratio for venous thromboembolism across categories of platelet count (<40th, 40-80th, and >80th percentile) with 95% confidence interval. RESULTS: During follow-up, 2082 subjects were diagnosed with cancer. Platelet count was measured on average 8.3 years before the cancer diagnosis. There were 129 venous thromboembolism events in the cancer cohort (13.5 per 1000 person-years) and 377 in the non-cancer cohort (1.2 per 1000 person-years). In cancer patients, pre-cancer platelet count above the 80th percentile (≥295×10(9)/L) was associated with a 2-fold higher risk of venous thromboembolism (Hazard ratio: 1.98, 95% confidence interval 1.21-3.23) compared to platelet count below the 40th percentile (<235×10(9)/L). Concomitant high platelet and leukocyte counts showed a synergistic effect on the VTE risk. In cancer-free subjects, no association was found. COMMENT: In conclusion, pre-cancer platelet count was associated with risk of symptomatic venous thromboembolism in cancer patients, but not in cancer-free subjects. Our findings suggest that platelet count and platelet-leukocyte interactions may play a role in the pathogenesis of cancer-related venous thromboembolism. |
format |
Article in Journal/Newspaper |
author |
Hilde Jensvoll Kristine Blix Sigrid K Brækkan John-Bjarne Hansen |
author_facet |
Hilde Jensvoll Kristine Blix Sigrid K Brækkan John-Bjarne Hansen |
author_sort |
Hilde Jensvoll |
title |
Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
title_short |
Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
title_full |
Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
title_fullStr |
Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
title_full_unstemmed |
Platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the Tromsø Study. |
title_sort |
platelet count measured prior to cancer development is a risk factor for future symptomatic venous thromboembolism: the tromsø study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pone.0092011 https://doaj.org/article/8c4fdfcf7a0647de811aee6df170a8d0 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS ONE, Vol 9, Iss 3, p e92011 (2014) |
op_relation |
http://europepmc.org/articles/PMC3958406?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0092011 https://doaj.org/article/8c4fdfcf7a0647de811aee6df170a8d0 |
op_doi |
https://doi.org/10.1371/journal.pone.0092011 |
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PLoS ONE |
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9 |
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3 |
container_start_page |
e92011 |
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1766219315225296896 |