Association of the AGT Gene M235T (rs699) Polymorphism with Arterial Hypertension and Metabolic Risk Factors in the Indigenous People of Yakutia

• Published in: International Journal of Biomedicine
• Main Authors: Sargylana Sofronova, Maria Kirillina, Irina Kononova, Anna Romanova, Vyacheslav Nikolaev, Sardana Kononova
• Format: Article in Journal/Newspaper
• Language: English
• Published: International Medical Research and Development Corporation 2019
• Subjects: agt gene; polymorphism; arterial hypertension; risk factors; indigenous people; Medicine; R; Arctic; Yakutia
• Online Access: https://doi.org/10.21103/Article9(4)_OA2; https://doaj.org/article/8c4843ba9470462684d0af0041538c8f

The research objective was to study the association of the AGT rs699 missense SNP with arterial hypertension (AH) and metabolic risk factors among indigenous people of the Arctic territory of Yakutia. The obtained data show that representatives of indigenous people of the Arctic territory of Yakutia with the homozygous GG genotype for the AGT SNP rs699 are characterized by high levels of systolic blood pressure. The carriage of the GG genotype in AH patients is associated with a high frequency of hypo-HDL cholesterolemia. The carriage of GG genotype in AH patients, compared to subjects without AH, is characterized by higher blood levels of total cholesterol, LDL-C, and triglycerides and is associated with a high frequency of abdominal obesity. Thus, the AGT rs699 missense SNP was found to be associated with metabolic risk factors in indigenous AH persons of the Arctic territory of Yakutia.