High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga.
Glossina fuscipes fuscipes is the major vector of human African trypanosomiasis, commonly referred to as sleeping sickness, in Uganda. In western and eastern Africa, the disease has distinct clinical manifestations and is caused by two different parasites: Trypanosoma brucei rhodesiense and T. b. ga...
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ftdoajarticles:oai:doaj.org/article:8c24ae2d4f6a438c8cc2aec97f137e0e 2023-05-15T15:10:47+02:00 High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. Patrick P Abila Michel A Slotman Aristeidis Parmakelis Kirstin B Dion Alan S Robinson Vincent B Muwanika John C K Enyaru Loyce M A Okedi Serap Aksoy Adalgisa Caccone 2008-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000242 https://doaj.org/article/8c24ae2d4f6a438c8cc2aec97f137e0e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2386243?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000242 https://doaj.org/article/8c24ae2d4f6a438c8cc2aec97f137e0e PLoS Neglected Tropical Diseases, Vol 2, Iss 5, p e242 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000242 2023-01-08T01:27:15Z Glossina fuscipes fuscipes is the major vector of human African trypanosomiasis, commonly referred to as sleeping sickness, in Uganda. In western and eastern Africa, the disease has distinct clinical manifestations and is caused by two different parasites: Trypanosoma brucei rhodesiense and T. b. gambiense. Uganda is exceptional in that it harbors both parasites, which are separated by a narrow 160-km belt. This separation is puzzling considering there are no restrictions on the movement of people and animals across this region.We investigated whether genetic heterogeneity of G. f. fuscipes vector populations can provide an explanation for this disjunct distribution of the Trypanosoma parasites. Therefore, we examined genetic structuring of G. f. fuscipes populations across Uganda using newly developed microsatellite markers, as well as mtDNA. Our data show that G. f. fuscipes populations are highly structured, with two clearly defined clusters that are separated by Lake Kyoga, located in central Uganda. Interestingly, we did not find a correlation between genetic heterogeneity and the type of Trypanosoma parasite transmitted.The lack of a correlation between genetic structuring of G. f. fuscipes populations and the distribution of T. b. gambiense and T. b. rhodesiense indicates that it is unlikely that genetic heterogeneity of G. f. fuscipes populations explains the disjunct distribution of the parasites. These results have important epidemiological implications, suggesting that a fusion of the two disease distributions is unlikely to be prevented by an incompatibility between vector populations and parasite. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 5 e242 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patrick P Abila Michel A Slotman Aristeidis Parmakelis Kirstin B Dion Alan S Robinson Vincent B Muwanika John C K Enyaru Loyce M A Okedi Serap Aksoy Adalgisa Caccone High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Glossina fuscipes fuscipes is the major vector of human African trypanosomiasis, commonly referred to as sleeping sickness, in Uganda. In western and eastern Africa, the disease has distinct clinical manifestations and is caused by two different parasites: Trypanosoma brucei rhodesiense and T. b. gambiense. Uganda is exceptional in that it harbors both parasites, which are separated by a narrow 160-km belt. This separation is puzzling considering there are no restrictions on the movement of people and animals across this region.We investigated whether genetic heterogeneity of G. f. fuscipes vector populations can provide an explanation for this disjunct distribution of the Trypanosoma parasites. Therefore, we examined genetic structuring of G. f. fuscipes populations across Uganda using newly developed microsatellite markers, as well as mtDNA. Our data show that G. f. fuscipes populations are highly structured, with two clearly defined clusters that are separated by Lake Kyoga, located in central Uganda. Interestingly, we did not find a correlation between genetic heterogeneity and the type of Trypanosoma parasite transmitted.The lack of a correlation between genetic structuring of G. f. fuscipes populations and the distribution of T. b. gambiense and T. b. rhodesiense indicates that it is unlikely that genetic heterogeneity of G. f. fuscipes populations explains the disjunct distribution of the parasites. These results have important epidemiological implications, suggesting that a fusion of the two disease distributions is unlikely to be prevented by an incompatibility between vector populations and parasite. |
format |
Article in Journal/Newspaper |
author |
Patrick P Abila Michel A Slotman Aristeidis Parmakelis Kirstin B Dion Alan S Robinson Vincent B Muwanika John C K Enyaru Loyce M A Okedi Serap Aksoy Adalgisa Caccone |
author_facet |
Patrick P Abila Michel A Slotman Aristeidis Parmakelis Kirstin B Dion Alan S Robinson Vincent B Muwanika John C K Enyaru Loyce M A Okedi Serap Aksoy Adalgisa Caccone |
author_sort |
Patrick P Abila |
title |
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
title_short |
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
title_full |
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
title_fullStr |
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
title_full_unstemmed |
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. |
title_sort |
high levels of genetic differentiation between ugandan glossina fuscipes fuscipes populations separated by lake kyoga. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000242 https://doaj.org/article/8c24ae2d4f6a438c8cc2aec97f137e0e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 5, p e242 (2008) |
op_relation |
http://europepmc.org/articles/PMC2386243?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000242 https://doaj.org/article/8c24ae2d4f6a438c8cc2aec97f137e0e |
op_doi |
https://doi.org/10.1371/journal.pntd.0000242 |
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PLoS Neglected Tropical Diseases |
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2 |
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5 |
container_start_page |
e242 |
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1766341743788163072 |