Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection
Abstract Background Epigastric pain, vomiting, and other gastrointestinal problems are among the most important symptoms of malaria infection as they suggest the possibility that the condition is serious. Pathophysiologies such as gastric mucosal changes and delayed gastric emptying have been report...
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ftdoajarticles:oai:doaj.org/article:8be829e49f9446c6baf1cc08c3e83cc5 2023-05-15T15:11:50+02:00 Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection Mizuho Shimada Yoshie Hirose Kazuhiko Shimizu Daisuke S. Yamamoto Eri H. Hayakawa Hiroyuki Matsuoka 2019-03-01T00:00:00Z https://doi.org/10.1186/s41182-019-0146-9 https://doaj.org/article/8be829e49f9446c6baf1cc08c3e83cc5 EN eng BMC http://link.springer.com/article/10.1186/s41182-019-0146-9 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-019-0146-9 1349-4147 https://doaj.org/article/8be829e49f9446c6baf1cc08c3e83cc5 Tropical Medicine and Health, Vol 47, Iss 1, Pp 1-11 (2019) Plasmodium berghei ANKA Anopheles stephensi Stomach Small intestine Gastric red patches Submucosal edema Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1186/s41182-019-0146-9 2022-12-31T02:04:40Z Abstract Background Epigastric pain, vomiting, and other gastrointestinal problems are among the most important symptoms of malaria infection as they suggest the possibility that the condition is serious. Pathophysiologies such as gastric mucosal changes and delayed gastric emptying have been reported in serious cases of malaria infection. However, it is unclear whether or not pathophysiological involvement of the upper gastrointestinal tract occurs in Plasmodium berghei ANKA (PbA)-infected mice. Methods PbA-infective Anopheles mosquitoes were used to infect mice via the natural route of infection. Fifteen PbA-C57BL/6 mice were used as a cerebral malaria model and the same numbers of PbA-BALB/c mice were used as a cerebral malaria-resistant model, and then we investigated the pathophysiological involvement of the stomach and small intestine. Results On day 8 post infection, six PbA-C57BL/6 mice showed cerebral malaria and nine others had uncomplicated infection. All the PbA-C57BL/6 mice on that same day showed severe weight loss with multiple, red gastric patches and changes to the course of the small intestine with villus goblet cell enlargement. In addition, cerebral malaria cases showed gastric gas retention with submucosal edema and small intestinal shortening. In PbA-BALB/c mice, overextension of the stomach and gas retention were evident from week 2 after PbA infection, as well as changes to the course of the small intestine and mesenteric thinning with fragility. Conclusions We described the upper gastrointestinal pathophysiology representing new findings directly linked to malarial severity and subsequent death in PbA-infected mice as a mouse model of malaria infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 47 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Plasmodium berghei ANKA Anopheles stephensi Stomach Small intestine Gastric red patches Submucosal edema Arctic medicine. Tropical medicine RC955-962 |
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Plasmodium berghei ANKA Anopheles stephensi Stomach Small intestine Gastric red patches Submucosal edema Arctic medicine. Tropical medicine RC955-962 Mizuho Shimada Yoshie Hirose Kazuhiko Shimizu Daisuke S. Yamamoto Eri H. Hayakawa Hiroyuki Matsuoka Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
topic_facet |
Plasmodium berghei ANKA Anopheles stephensi Stomach Small intestine Gastric red patches Submucosal edema Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Epigastric pain, vomiting, and other gastrointestinal problems are among the most important symptoms of malaria infection as they suggest the possibility that the condition is serious. Pathophysiologies such as gastric mucosal changes and delayed gastric emptying have been reported in serious cases of malaria infection. However, it is unclear whether or not pathophysiological involvement of the upper gastrointestinal tract occurs in Plasmodium berghei ANKA (PbA)-infected mice. Methods PbA-infective Anopheles mosquitoes were used to infect mice via the natural route of infection. Fifteen PbA-C57BL/6 mice were used as a cerebral malaria model and the same numbers of PbA-BALB/c mice were used as a cerebral malaria-resistant model, and then we investigated the pathophysiological involvement of the stomach and small intestine. Results On day 8 post infection, six PbA-C57BL/6 mice showed cerebral malaria and nine others had uncomplicated infection. All the PbA-C57BL/6 mice on that same day showed severe weight loss with multiple, red gastric patches and changes to the course of the small intestine with villus goblet cell enlargement. In addition, cerebral malaria cases showed gastric gas retention with submucosal edema and small intestinal shortening. In PbA-BALB/c mice, overextension of the stomach and gas retention were evident from week 2 after PbA infection, as well as changes to the course of the small intestine and mesenteric thinning with fragility. Conclusions We described the upper gastrointestinal pathophysiology representing new findings directly linked to malarial severity and subsequent death in PbA-infected mice as a mouse model of malaria infection. |
format |
Article in Journal/Newspaper |
author |
Mizuho Shimada Yoshie Hirose Kazuhiko Shimizu Daisuke S. Yamamoto Eri H. Hayakawa Hiroyuki Matsuoka |
author_facet |
Mizuho Shimada Yoshie Hirose Kazuhiko Shimizu Daisuke S. Yamamoto Eri H. Hayakawa Hiroyuki Matsuoka |
author_sort |
Mizuho Shimada |
title |
Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
title_short |
Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
title_full |
Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
title_fullStr |
Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
title_full_unstemmed |
Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection |
title_sort |
upper gastrointestinal pathophysiology due to mouse malaria plasmodium berghei anka infection |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s41182-019-0146-9 https://doaj.org/article/8be829e49f9446c6baf1cc08c3e83cc5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 47, Iss 1, Pp 1-11 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s41182-019-0146-9 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-019-0146-9 1349-4147 https://doaj.org/article/8be829e49f9446c6baf1cc08c3e83cc5 |
op_doi |
https://doi.org/10.1186/s41182-019-0146-9 |
container_title |
Tropical Medicine and Health |
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47 |
container_issue |
1 |
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1766342622422499328 |