Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study
Objective: To evaluate the clinical safety and efficacy of Lianhuaqingwen (LHQW) capsules in patients with high-risk common type COVID-19 pneumonia. Methods: A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted. Patients were categorized as the standa...
Published in: | Asian Pacific Journal of Tropical Medicine |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2023
|
Subjects: | |
Online Access: | https://doi.org/10.4103/1995-7645.386076 https://doaj.org/article/8b3156c6a7c645f3bcd4aee9665ea782 |
id |
ftdoajarticles:oai:doaj.org/article:8b3156c6a7c645f3bcd4aee9665ea782 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:8b3156c6a7c645f3bcd4aee9665ea782 2023-11-12T04:13:46+01:00 Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study Bin Liu Liang Li Lei Liu Min Ye Wei Zhang Xiangdong Zhou Qi Li 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.386076 https://doaj.org/article/8b3156c6a7c645f3bcd4aee9665ea782 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=9;spage=418;epage=424;aulast=Liu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.386076 https://doaj.org/article/8b3156c6a7c645f3bcd4aee9665ea782 Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 9, Pp 418-424 (2023) lianhuaqingwen capsules covid-19 pneumonia high-risk common type clinical efficacy Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.386076 2023-10-29T00:38:43Z Objective: To evaluate the clinical safety and efficacy of Lianhuaqingwen (LHQW) capsules in patients with high-risk common type COVID-19 pneumonia. Methods: A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted. Patients were categorized as the standard treatment (SDT) group (n=168) and the LHQW+SDT group (n=215). The primary endpoint was the rate of symptom (fever, fatigue, coughing) recovery and the secondary endpoints included the time to symptom recovery, the proportion of patients with improvement in chest CT images, the proportion of patients with clinical cure, the timing and rate of negative conversion of SARS-CoV-2 RNA assay. Results: The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group (89.7% vs. 72.0%, P<0.01). The combined use of LHQW+SDT also showed shorter time for symptom recovery, as well as shorter time for individual symptom of fever, fatigue and coughing recovery than use of SDT alone. A higher proportion of patients in the LHQW+SDT group with improvements in chest CT images and clinical cure (77.7% vs. 57.1%, P<0.01) but the proportion of patients deteriorating to severe cases (1% vs. 25%, P<0.01) in this group was significant lower than those in the SDT group. No significant difference in negative conversion rate of viral assay results was observed (76.8% vs. 75.0%, P>0.05). No serious adverse events were reported. Conclusions: LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Medicine 16 9 418 424 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lianhuaqingwen capsules covid-19 pneumonia high-risk common type clinical efficacy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
lianhuaqingwen capsules covid-19 pneumonia high-risk common type clinical efficacy Arctic medicine. Tropical medicine RC955-962 Bin Liu Liang Li Lei Liu Min Ye Wei Zhang Xiangdong Zhou Qi Li Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
topic_facet |
lianhuaqingwen capsules covid-19 pneumonia high-risk common type clinical efficacy Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the clinical safety and efficacy of Lianhuaqingwen (LHQW) capsules in patients with high-risk common type COVID-19 pneumonia. Methods: A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted. Patients were categorized as the standard treatment (SDT) group (n=168) and the LHQW+SDT group (n=215). The primary endpoint was the rate of symptom (fever, fatigue, coughing) recovery and the secondary endpoints included the time to symptom recovery, the proportion of patients with improvement in chest CT images, the proportion of patients with clinical cure, the timing and rate of negative conversion of SARS-CoV-2 RNA assay. Results: The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group (89.7% vs. 72.0%, P<0.01). The combined use of LHQW+SDT also showed shorter time for symptom recovery, as well as shorter time for individual symptom of fever, fatigue and coughing recovery than use of SDT alone. A higher proportion of patients in the LHQW+SDT group with improvements in chest CT images and clinical cure (77.7% vs. 57.1%, P<0.01) but the proportion of patients deteriorating to severe cases (1% vs. 25%, P<0.01) in this group was significant lower than those in the SDT group. No significant difference in negative conversion rate of viral assay results was observed (76.8% vs. 75.0%, P>0.05). No serious adverse events were reported. Conclusions: LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia. |
format |
Article in Journal/Newspaper |
author |
Bin Liu Liang Li Lei Liu Min Ye Wei Zhang Xiangdong Zhou Qi Li |
author_facet |
Bin Liu Liang Li Lei Liu Min Ye Wei Zhang Xiangdong Zhou Qi Li |
author_sort |
Bin Liu |
title |
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
title_short |
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
title_full |
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
title_fullStr |
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
title_full_unstemmed |
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study |
title_sort |
efficacy and safety of lianhuaqingwen capsules in high-risk common type covid-19 pneumonia: a multicenter retrospective study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.386076 https://doaj.org/article/8b3156c6a7c645f3bcd4aee9665ea782 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 9, Pp 418-424 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=9;spage=418;epage=424;aulast=Liu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.386076 https://doaj.org/article/8b3156c6a7c645f3bcd4aee9665ea782 |
op_doi |
https://doi.org/10.4103/1995-7645.386076 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
9 |
container_start_page |
418 |
op_container_end_page |
424 |
_version_ |
1782331616998195200 |