Congenital cytomegalovirus mortality in the United States, 1990-2006.
BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most common intrauterine infection in the United States disproportionately affecting minority races and those of lower socio-economic class. Despite its importance there is little information on the burden of congenital CMV-related mortali...
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ftdoajarticles:oai:doaj.org/article:8b1458ed25714ab9bbe58bb666f7f997 2023-05-15T15:12:38+02:00 Congenital cytomegalovirus mortality in the United States, 1990-2006. Benjamin N Bristow Kaitlin A O'Keefe Shira C Shafir Frank J Sorvillo 2011-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001140 https://doaj.org/article/8b1458ed25714ab9bbe58bb666f7f997 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3082510?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001140 https://doaj.org/article/8b1458ed25714ab9bbe58bb666f7f997 PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1140 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001140 2022-12-31T05:55:47Z BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most common intrauterine infection in the United States disproportionately affecting minority races and those of lower socio-economic class. Despite its importance there is little information on the burden of congenital CMV-related mortality in the US. To measure congenital CMV-associated mortality in the US and assess possible racial/ethnic disparities, we reviewed national death certificate data for a 17-year period. METHODS:Congenital CMV-associated deaths from 1990 through 2006 were identified from multiple-cause-coded death records and were combined with US census data to calculate mortality rates. RESULTS:A total of 777 congenital CMV-associated deaths occurred over the 17-year study period resulting in 56,355 years of age-adjusted years of potential life lost. 71.7% (557) of congenital CMV-associated deaths occurred in infants (age less than 1 year). Age-adjusted mortality rates stratified by race/ethnicity revealed mortality disparities. Age-adjusted rate ratios were calculated for each racial/ethnic group using whites as the reference. Native Americans and African Americans were 2.34 (95% CI, 2.11-2.59) and 1.89 (95% CI, 1.70-2.11) times respectively, more likely to die from congenital CMV than whites. Asians and Hispanics were 0.54 (95% CI, 0.44-0.66) and 0.96 (95% CI, 0.83-1.10) times respectively, less likely to die from congenital CMV than whites. CONCLUSIONS/SIGNIFICANCE:Congenital CMV infection causes appreciable mortality in the US exacting a particular burden among African Americans and Native Americans. Enhanced surveillance and increased screening are necessary to better understand the epidemiology of congenital CMV infection in addition to acceleration of vaccine development efforts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 4 e1140 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Benjamin N Bristow Kaitlin A O'Keefe Shira C Shafir Frank J Sorvillo Congenital cytomegalovirus mortality in the United States, 1990-2006. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most common intrauterine infection in the United States disproportionately affecting minority races and those of lower socio-economic class. Despite its importance there is little information on the burden of congenital CMV-related mortality in the US. To measure congenital CMV-associated mortality in the US and assess possible racial/ethnic disparities, we reviewed national death certificate data for a 17-year period. METHODS:Congenital CMV-associated deaths from 1990 through 2006 were identified from multiple-cause-coded death records and were combined with US census data to calculate mortality rates. RESULTS:A total of 777 congenital CMV-associated deaths occurred over the 17-year study period resulting in 56,355 years of age-adjusted years of potential life lost. 71.7% (557) of congenital CMV-associated deaths occurred in infants (age less than 1 year). Age-adjusted mortality rates stratified by race/ethnicity revealed mortality disparities. Age-adjusted rate ratios were calculated for each racial/ethnic group using whites as the reference. Native Americans and African Americans were 2.34 (95% CI, 2.11-2.59) and 1.89 (95% CI, 1.70-2.11) times respectively, more likely to die from congenital CMV than whites. Asians and Hispanics were 0.54 (95% CI, 0.44-0.66) and 0.96 (95% CI, 0.83-1.10) times respectively, less likely to die from congenital CMV than whites. CONCLUSIONS/SIGNIFICANCE:Congenital CMV infection causes appreciable mortality in the US exacting a particular burden among African Americans and Native Americans. Enhanced surveillance and increased screening are necessary to better understand the epidemiology of congenital CMV infection in addition to acceleration of vaccine development efforts. |
format |
Article in Journal/Newspaper |
author |
Benjamin N Bristow Kaitlin A O'Keefe Shira C Shafir Frank J Sorvillo |
author_facet |
Benjamin N Bristow Kaitlin A O'Keefe Shira C Shafir Frank J Sorvillo |
author_sort |
Benjamin N Bristow |
title |
Congenital cytomegalovirus mortality in the United States, 1990-2006. |
title_short |
Congenital cytomegalovirus mortality in the United States, 1990-2006. |
title_full |
Congenital cytomegalovirus mortality in the United States, 1990-2006. |
title_fullStr |
Congenital cytomegalovirus mortality in the United States, 1990-2006. |
title_full_unstemmed |
Congenital cytomegalovirus mortality in the United States, 1990-2006. |
title_sort |
congenital cytomegalovirus mortality in the united states, 1990-2006. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001140 https://doaj.org/article/8b1458ed25714ab9bbe58bb666f7f997 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1140 (2011) |
op_relation |
http://europepmc.org/articles/PMC3082510?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001140 https://doaj.org/article/8b1458ed25714ab9bbe58bb666f7f997 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001140 |
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PLoS Neglected Tropical Diseases |
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5 |
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4 |
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e1140 |
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