Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control
Michael J Taylor, Tara A Garrard, Francis J O'Donahoo, Kirstin E Ross Health and Environment, School of the Environment, Flinders University, Adelaide, SA, Australia Abstract: Strongyloides is a human parasitic nematode that is poorly understood outside a clinical context. This article identifi...
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ftdoajarticles:oai:doaj.org/article:8af60a1f29d143c7b6de205abe9f87c4 2023-05-15T15:13:29+02:00 Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control Taylor MJ Garrard TA O'Donahoo FJ Ross KE 2014-08-01T00:00:00Z https://doaj.org/article/8af60a1f29d143c7b6de205abe9f87c4 EN eng Dove Medical Press http://www.dovepress.com/human-strongyloidiasis-identifying-knowledge-gaps-with-emphasis-on-env-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/8af60a1f29d143c7b6de205abe9f87c4 Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 55-63 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles 2022-12-31T13:23:56Z Michael J Taylor, Tara A Garrard, Francis J O'Donahoo, Kirstin E Ross Health and Environment, School of the Environment, Flinders University, Adelaide, SA, Australia Abstract: Strongyloides is a human parasitic nematode that is poorly understood outside a clinical context. This article identifies gaps within the literature, with particular emphasis on gaps that are hindering environmental control of Strongyloides. The prevalence and distribution of Strongyloides is unclear. An estimate of 100–370 million people infected worldwide has been proposed; however, inaccuracy of diagnosis, unreliability of prevalence mapping, and the fact that strongyloidiasis remains a neglected disease suggest that the higher figure of more than 300 million cases is likely to be a more accurate estimate. The complexity of Strongyloides life cycle means that laboratory cultures cannot be maintained outside of a host. This currently limits the range of laboratory-based research, which is vital to controlling Strongyloides through environmental alteration or treatment. Successful clinical treatment with antihelminthic drugs has meant that controlling Strongyloides through environmental control, rather than clinical intervention, has been largely overlooked. These control measures may encompass alteration of the soil environment through physical means, such as desiccation or removal of nutrients, or through chemical or biological agents. Repeated antihelminthic treatment of individuals with recurrent strongyloidiasis has not been observed to result in the selection of resistant strains; however, this has not been explicitly demonstrated, and relying on such assumptions in the long-term may prove to be shortsighted. It is ultimately naive to assume that continued administration of antihelminthics will be without any negative long-term effects. In Australia, strongyloidiasis primarily affects Indigenous communities, including communities from arid central Australia. This suggests that the range of Strongyloides extends beyond the reported ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Flinders ENVELOPE(-66.667,-66.667,-69.267,-69.267) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Taylor MJ Garrard TA O'Donahoo FJ Ross KE Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Michael J Taylor, Tara A Garrard, Francis J O'Donahoo, Kirstin E Ross Health and Environment, School of the Environment, Flinders University, Adelaide, SA, Australia Abstract: Strongyloides is a human parasitic nematode that is poorly understood outside a clinical context. This article identifies gaps within the literature, with particular emphasis on gaps that are hindering environmental control of Strongyloides. The prevalence and distribution of Strongyloides is unclear. An estimate of 100–370 million people infected worldwide has been proposed; however, inaccuracy of diagnosis, unreliability of prevalence mapping, and the fact that strongyloidiasis remains a neglected disease suggest that the higher figure of more than 300 million cases is likely to be a more accurate estimate. The complexity of Strongyloides life cycle means that laboratory cultures cannot be maintained outside of a host. This currently limits the range of laboratory-based research, which is vital to controlling Strongyloides through environmental alteration or treatment. Successful clinical treatment with antihelminthic drugs has meant that controlling Strongyloides through environmental control, rather than clinical intervention, has been largely overlooked. These control measures may encompass alteration of the soil environment through physical means, such as desiccation or removal of nutrients, or through chemical or biological agents. Repeated antihelminthic treatment of individuals with recurrent strongyloidiasis has not been observed to result in the selection of resistant strains; however, this has not been explicitly demonstrated, and relying on such assumptions in the long-term may prove to be shortsighted. It is ultimately naive to assume that continued administration of antihelminthics will be without any negative long-term effects. In Australia, strongyloidiasis primarily affects Indigenous communities, including communities from arid central Australia. This suggests that the range of Strongyloides extends beyond the reported ... |
format |
Article in Journal/Newspaper |
author |
Taylor MJ Garrard TA O'Donahoo FJ Ross KE |
author_facet |
Taylor MJ Garrard TA O'Donahoo FJ Ross KE |
author_sort |
Taylor MJ |
title |
Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
title_short |
Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
title_full |
Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
title_fullStr |
Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
title_full_unstemmed |
Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
title_sort |
human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control |
publisher |
Dove Medical Press |
publishDate |
2014 |
url |
https://doaj.org/article/8af60a1f29d143c7b6de205abe9f87c4 |
long_lat |
ENVELOPE(-66.667,-66.667,-69.267,-69.267) |
geographic |
Arctic Flinders |
geographic_facet |
Arctic Flinders |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 55-63 (2014) |
op_relation |
http://www.dovepress.com/human-strongyloidiasis-identifying-knowledge-gaps-with-emphasis-on-env-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/8af60a1f29d143c7b6de205abe9f87c4 |
_version_ |
1766344044694208512 |