Durable wall lining for malaria control in Liberia: results of a cluster randomized trial

• Published in: Malaria Journal
• Main Authors: David Giesbrecht, Tuwuyor G. Belleh, Julie Pontarollo, Victor S. Hinneh, Oliver Pratt, Sajid Kamal, Richard Allan
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2023
• Subjects: Malaria; Vectors; LLINs; Durable wall lining; Rural housing; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1186/s12936-022-04429-7; https://doaj.org/article/8af332ec701f4649a69b99177eaf6f2a

Abstract Background Malaria control in Liberia depends upon universal coverage with pyrethroid-impregnated long-lasting insecticidal nets (LLINs). Despite regular mass distribution, LLIN coverage and usage is patchy. Pyrethroid resistance in malaria vectors may further reduce LLIN efficacy. Durable Wall Lining (DWL), a novel material treated with two non-pyrethroid class insecticides, was designed to be installed onto the surface of inner walls, and cover openings and ceiling surfaces of rural houses. Objectives Aim To determine the malaria control efficacy of DWL. Primary objective To determine if DWL has an additional protective effect in an area of pyrethroid resistance. Secondary objectives To compare surface bio-availability of insecticides and entomological effectiveness over the study duration. Design A cluster randomized trial. Participants Children aged 2–59 months. Control arm 50 houses per 20 clusters, all of which received LLIN within the previous 12 months. Active arm 50 houses per 20 experimental clusters, all of which received LLINs with the previous 12 months, and had internal walls and ceilings lined with DWL. Randomisation Cluster villages were randomly allocated to control or active arms, and paired on 4 covariates. Main outcome measures Primary measure Prevalence of infection with P. falciparum in children aged 2 to 59 months. Secondary measure Surface bioavailability and entomological effectiveness of DWL active ingredients. Results Plasmodium falciparum prevalence in active clusters after 12 months was 34.6% compared to 40.1% in control clusters (p = 0.052). The effect varied with elevation and was significant (RR = 1.3, p = 0.022) in 14 pairs of upland villages. It was not significant (RR = 1.3, p = 0.344) in 6 pairs of coastal villages. Pooled risk ratio (RR) was calculated in SAS (Cary, NC, USA) using the Cochran–Mantel–Haenszel (CMH) test for upland and coastal cluster pairs. DWL efficacy was sustained at almost 100% for 12 months. Conclusions Findings indicate that DWL is a scalable ...