Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017
Background: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. Objective: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergi...
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ftdoajarticles:oai:doaj.org/article:8a9226fd9fdb4afa8f6b325d6a03d8ea 2023-12-10T09:52:10+01:00 Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 Eva Rönmark, PhD Joakim Bunne, MD Anders Bjerg, MD, PhD Matthew Perzanowski, PhD Anna Winberg, MD, PhD Martin Andersson, MD, PhD Thomas Platts-Mills, MD, PhD Linnea Hedman, PhD 2023-11-01T00:00:00Z https://doi.org/10.1016/j.jacig.2023.100150 https://doaj.org/article/8a9226fd9fdb4afa8f6b325d6a03d8ea EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2772829323000759 https://doaj.org/toc/2772-8293 2772-8293 doi:10.1016/j.jacig.2023.100150 https://doaj.org/article/8a9226fd9fdb4afa8f6b325d6a03d8ea Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100150- (2023) Allergic sensitization asthma allergic rhinitis epidemiology OLIN schoolchildren Immunologic diseases. Allergy RC581-607 article 2023 ftdoajarticles https://doi.org/10.1016/j.jacig.2023.100150 2023-11-12T01:36:59Z Background: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. Objective: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergic rhinitis (AR) among children in Northern Sweden. Methods: Three cohorts of children aged 7 to 8 years participated in a skin prick test (SPT) with 10 airborne allergens in 1996, 2006, and 2017, with 2148, 1693, and 1762 participants tested, respectively, representing 87% to 90% of schoolchildren in the catchment communities. Adjusted Poisson regression was used to identify risk factors for allergic sensitization and the association with asthma and AR. Results: The prevalence of any positive SPT response increased from 21% in 1996 to 30% in 2006 and remained at 30% in 2017 (P < .001). Sensitization to cat was the most common for all the years. The risk factor pattern for a positive SPT response was similar in all examinations, with positive and significant associations with a family history of allergy (risk ratio, 1.4-1.5) and negative and significant associations with having a cat at home (risk ratio, 0.7-0.8). The prevalence of physician-diagnosed asthma increased, but the association with allergic sensitization weakened. The opposite trends were found for AR—decreasing prevalence and strengthened association with allergic sensitization. Conclusions: The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR suggest secular trends in the clinical management of allergic diseases. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Journal of Allergy and Clinical Immunology: Global 2 4 100150 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Allergic sensitization asthma allergic rhinitis epidemiology OLIN schoolchildren Immunologic diseases. Allergy RC581-607 |
spellingShingle |
Allergic sensitization asthma allergic rhinitis epidemiology OLIN schoolchildren Immunologic diseases. Allergy RC581-607 Eva Rönmark, PhD Joakim Bunne, MD Anders Bjerg, MD, PhD Matthew Perzanowski, PhD Anna Winberg, MD, PhD Martin Andersson, MD, PhD Thomas Platts-Mills, MD, PhD Linnea Hedman, PhD Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
topic_facet |
Allergic sensitization asthma allergic rhinitis epidemiology OLIN schoolchildren Immunologic diseases. Allergy RC581-607 |
description |
Background: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. Objective: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergic rhinitis (AR) among children in Northern Sweden. Methods: Three cohorts of children aged 7 to 8 years participated in a skin prick test (SPT) with 10 airborne allergens in 1996, 2006, and 2017, with 2148, 1693, and 1762 participants tested, respectively, representing 87% to 90% of schoolchildren in the catchment communities. Adjusted Poisson regression was used to identify risk factors for allergic sensitization and the association with asthma and AR. Results: The prevalence of any positive SPT response increased from 21% in 1996 to 30% in 2006 and remained at 30% in 2017 (P < .001). Sensitization to cat was the most common for all the years. The risk factor pattern for a positive SPT response was similar in all examinations, with positive and significant associations with a family history of allergy (risk ratio, 1.4-1.5) and negative and significant associations with having a cat at home (risk ratio, 0.7-0.8). The prevalence of physician-diagnosed asthma increased, but the association with allergic sensitization weakened. The opposite trends were found for AR—decreasing prevalence and strengthened association with allergic sensitization. Conclusions: The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR suggest secular trends in the clinical management of allergic diseases. |
format |
Article in Journal/Newspaper |
author |
Eva Rönmark, PhD Joakim Bunne, MD Anders Bjerg, MD, PhD Matthew Perzanowski, PhD Anna Winberg, MD, PhD Martin Andersson, MD, PhD Thomas Platts-Mills, MD, PhD Linnea Hedman, PhD |
author_facet |
Eva Rönmark, PhD Joakim Bunne, MD Anders Bjerg, MD, PhD Matthew Perzanowski, PhD Anna Winberg, MD, PhD Martin Andersson, MD, PhD Thomas Platts-Mills, MD, PhD Linnea Hedman, PhD |
author_sort |
Eva Rönmark, PhD |
title |
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_short |
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_full |
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_fullStr |
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_full_unstemmed |
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_sort |
prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.jacig.2023.100150 https://doaj.org/article/8a9226fd9fdb4afa8f6b325d6a03d8ea |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100150- (2023) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2772829323000759 https://doaj.org/toc/2772-8293 2772-8293 doi:10.1016/j.jacig.2023.100150 https://doaj.org/article/8a9226fd9fdb4afa8f6b325d6a03d8ea |
op_doi |
https://doi.org/10.1016/j.jacig.2023.100150 |
container_title |
Journal of Allergy and Clinical Immunology: Global |
container_volume |
2 |
container_issue |
4 |
container_start_page |
100150 |
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1784898160382967808 |