Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden
Background: Since Strongyloides can persist in its host for decades, and cause life threatening infections data on prevalence, the burden and risk factors for infection is crucial in migrant populations. Methods: In this observational retrospective cohort study, we describe the epidemiological, clin...
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ftdoajarticles:oai:doaj.org/article:8a1f2ef129e0409fb18688054207567b 2024-01-14T10:04:48+01:00 Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden Ana Requena-Méndez Emilia Roos Suzanne D. van der Werff Katja Wyss Leigh Davidsson Pontus Naucler Anna Färnert Hilmir Asgeirsson 2023-11-01T00:00:00Z https://doi.org/10.1016/j.tmaid.2023.102666 https://doaj.org/article/8a1f2ef129e0409fb18688054207567b EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1477893923001266 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102666 https://doaj.org/article/8a1f2ef129e0409fb18688054207567b Travel Medicine and Infectious Disease, Vol 56, Iss , Pp 102666- (2023) Strongyloides Sweden Migrants Travellers Serology PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1016/j.tmaid.2023.102666 2023-12-17T01:50:15Z Background: Since Strongyloides can persist in its host for decades, and cause life threatening infections data on prevalence, the burden and risk factors for infection is crucial in migrant populations. Methods: In this observational retrospective cohort study, we describe the epidemiological, clinical, and microbiological characteristics of imported strongyloidiasis diagnosed at the Karolinska University Hospital, Stockholm, Sweden, during 2010–2021. Results: We identified 98 individuals with strongyloidiasis, 89 (90.8%) born in endemic and 9 (9.2%) in non-endemic countries. Sub-Saharan Africa was the most common origin among the group born in endemic countries (62, 69.7%), (p < 0.005). There were 22 individuals with an underlying immunosuppressive condition.Gastrointestinal symptoms (53/98, 54.1%) were the symptoms most frequently described, and were more frequent in adults (57.0%) vs children (0%) (p = 0.013). Eosinophilia was detected in 74 (75.5%), being more frequent in the endemic-borne group (79.8% vs 33.3%, p = 0.002). Eight persons developed complications of strongyloidiasis because of either hyperinfection or disseminated disease. No people living with HIV with CD4 <500/mm3 (n = 6) developed severe strongyloidiasis. Conclusion: A limited number of strongyloidiasis cases was identified, with few complicated cases in immunosuppressed patients. Further studies focusing on identifying and exploring the risk of complicated strongyloidiasis in immunosuppressed patients are needed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Travel Medicine and Infectious Disease 56 102666 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Strongyloides Sweden Migrants Travellers Serology PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Strongyloides Sweden Migrants Travellers Serology PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ana Requena-Méndez Emilia Roos Suzanne D. van der Werff Katja Wyss Leigh Davidsson Pontus Naucler Anna Färnert Hilmir Asgeirsson Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
topic_facet |
Strongyloides Sweden Migrants Travellers Serology PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Background: Since Strongyloides can persist in its host for decades, and cause life threatening infections data on prevalence, the burden and risk factors for infection is crucial in migrant populations. Methods: In this observational retrospective cohort study, we describe the epidemiological, clinical, and microbiological characteristics of imported strongyloidiasis diagnosed at the Karolinska University Hospital, Stockholm, Sweden, during 2010–2021. Results: We identified 98 individuals with strongyloidiasis, 89 (90.8%) born in endemic and 9 (9.2%) in non-endemic countries. Sub-Saharan Africa was the most common origin among the group born in endemic countries (62, 69.7%), (p < 0.005). There were 22 individuals with an underlying immunosuppressive condition.Gastrointestinal symptoms (53/98, 54.1%) were the symptoms most frequently described, and were more frequent in adults (57.0%) vs children (0%) (p = 0.013). Eosinophilia was detected in 74 (75.5%), being more frequent in the endemic-borne group (79.8% vs 33.3%, p = 0.002). Eight persons developed complications of strongyloidiasis because of either hyperinfection or disseminated disease. No people living with HIV with CD4 <500/mm3 (n = 6) developed severe strongyloidiasis. Conclusion: A limited number of strongyloidiasis cases was identified, with few complicated cases in immunosuppressed patients. Further studies focusing on identifying and exploring the risk of complicated strongyloidiasis in immunosuppressed patients are needed. |
format |
Article in Journal/Newspaper |
author |
Ana Requena-Méndez Emilia Roos Suzanne D. van der Werff Katja Wyss Leigh Davidsson Pontus Naucler Anna Färnert Hilmir Asgeirsson |
author_facet |
Ana Requena-Méndez Emilia Roos Suzanne D. van der Werff Katja Wyss Leigh Davidsson Pontus Naucler Anna Färnert Hilmir Asgeirsson |
author_sort |
Ana Requena-Méndez |
title |
Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
title_short |
Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
title_full |
Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
title_fullStr |
Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
title_full_unstemmed |
Clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, Stockholm, Sweden |
title_sort |
clinical presentation and diagnosis of imported strongyloidiasis at a tertiary hospital, stockholm, sweden |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.tmaid.2023.102666 https://doaj.org/article/8a1f2ef129e0409fb18688054207567b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Travel Medicine and Infectious Disease, Vol 56, Iss , Pp 102666- (2023) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1477893923001266 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102666 https://doaj.org/article/8a1f2ef129e0409fb18688054207567b |
op_doi |
https://doi.org/10.1016/j.tmaid.2023.102666 |
container_title |
Travel Medicine and Infectious Disease |
container_volume |
56 |
container_start_page |
102666 |
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1788059250373689344 |