Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide due to its close association to the metabolic syndrome of type 2 diabetes mellitus (T2DM), obesity and insulin resistance. However, the prevalence and severity of NAFLD in Greenland remain unexplored. We aimed to es...
Published in: | International Journal of Circumpolar Health |
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Taylor & Francis Group
2022
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Online Access: | https://doi.org/10.1080/22423982.2022.2065755 https://doaj.org/article/8a11f535f4f54ba3984ce575eed8b5a6 |
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ftdoajarticles:oai:doaj.org/article:8a11f535f4f54ba3984ce575eed8b5a6 2023-05-15T15:09:54+02:00 Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study Abdullah Ghassan Muhammad Frederik Orm Hansen Rasmus Hvidbjerg Gantzel Karsten Fleischer Rex Gerda Elisabeth Villadsen Henning Grønbæk Michael Lynge Pedersen 2022-12-01T00:00:00Z https://doi.org/10.1080/22423982.2022.2065755 https://doaj.org/article/8a11f535f4f54ba3984ce575eed8b5a6 EN eng Taylor & Francis Group https://www.tandfonline.com/doi/10.1080/22423982.2022.2065755 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2022.2065755 2242-3982 https://doaj.org/article/8a11f535f4f54ba3984ce575eed8b5a6 International Journal of Circumpolar Health, Vol 81, Iss 1 (2022) Liver steatosis liver fibrosis type-2 diabetes mellitus Greenland Greenland Inuit Danes Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1080/22423982.2022.2065755 2022-12-31T02:20:08Z Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide due to its close association to the metabolic syndrome of type 2 diabetes mellitus (T2DM), obesity and insulin resistance. However, the prevalence and severity of NAFLD in Greenland remain unexplored. We aimed to estimate the prevalence of liver steatosis and fibrosis among Greenlanders and Danes with T2DM living in Greenland using biochemical surrogate markers. We included 1409 Greenlanders and 182 Danes with T2DM in this register-based cross-sectional study. Greenlanders had higher BMI and plasma lipid levels and lower HbA1c levels compared with Danes (p<0.05). Their median alanine aminotransferase (ALAT) levels were similar. However, more Greenlanders had elevated ALAT levels (20.5% vs. 11.5%, p<0.05). Greenlanders had lower FIB-4 scores than Danes, 0.91 (IQR: 0.66–1.27) vs. 0.97 (IQR: 0.78–1.34), without difference in FIB-4 score categories (p=0.27). The prevalence of advanced fibrosis was low in both populations (1.7–2.6%). In conclusion, Greenlanders with T2DM had better glycaemic control despite higher BMI and plasma lipids. A larger proportion of Greenlanders had elevated plasma ALAT levels, while FIB-4 scores were lower than Danes. These findings suggest that Greenlanders with T2DM may be less likely to develop liver complications than Danes with T2DM in Greenland. Article in Journal/Newspaper Arctic Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic Greenland International Journal of Circumpolar Health 81 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Liver steatosis liver fibrosis type-2 diabetes mellitus Greenland Greenland Inuit Danes Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Liver steatosis liver fibrosis type-2 diabetes mellitus Greenland Greenland Inuit Danes Arctic medicine. Tropical medicine RC955-962 Abdullah Ghassan Muhammad Frederik Orm Hansen Rasmus Hvidbjerg Gantzel Karsten Fleischer Rex Gerda Elisabeth Villadsen Henning Grønbæk Michael Lynge Pedersen Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
topic_facet |
Liver steatosis liver fibrosis type-2 diabetes mellitus Greenland Greenland Inuit Danes Arctic medicine. Tropical medicine RC955-962 |
description |
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide due to its close association to the metabolic syndrome of type 2 diabetes mellitus (T2DM), obesity and insulin resistance. However, the prevalence and severity of NAFLD in Greenland remain unexplored. We aimed to estimate the prevalence of liver steatosis and fibrosis among Greenlanders and Danes with T2DM living in Greenland using biochemical surrogate markers. We included 1409 Greenlanders and 182 Danes with T2DM in this register-based cross-sectional study. Greenlanders had higher BMI and plasma lipid levels and lower HbA1c levels compared with Danes (p<0.05). Their median alanine aminotransferase (ALAT) levels were similar. However, more Greenlanders had elevated ALAT levels (20.5% vs. 11.5%, p<0.05). Greenlanders had lower FIB-4 scores than Danes, 0.91 (IQR: 0.66–1.27) vs. 0.97 (IQR: 0.78–1.34), without difference in FIB-4 score categories (p=0.27). The prevalence of advanced fibrosis was low in both populations (1.7–2.6%). In conclusion, Greenlanders with T2DM had better glycaemic control despite higher BMI and plasma lipids. A larger proportion of Greenlanders had elevated plasma ALAT levels, while FIB-4 scores were lower than Danes. These findings suggest that Greenlanders with T2DM may be less likely to develop liver complications than Danes with T2DM in Greenland. |
format |
Article in Journal/Newspaper |
author |
Abdullah Ghassan Muhammad Frederik Orm Hansen Rasmus Hvidbjerg Gantzel Karsten Fleischer Rex Gerda Elisabeth Villadsen Henning Grønbæk Michael Lynge Pedersen |
author_facet |
Abdullah Ghassan Muhammad Frederik Orm Hansen Rasmus Hvidbjerg Gantzel Karsten Fleischer Rex Gerda Elisabeth Villadsen Henning Grønbæk Michael Lynge Pedersen |
author_sort |
Abdullah Ghassan Muhammad |
title |
Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
title_short |
Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
title_full |
Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
title_fullStr |
Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
title_full_unstemmed |
Non-alcoholic fatty liver disease in patients with type 2 diabetes in Greenland: a register-based cross-sectional study |
title_sort |
non-alcoholic fatty liver disease in patients with type 2 diabetes in greenland: a register-based cross-sectional study |
publisher |
Taylor & Francis Group |
publishDate |
2022 |
url |
https://doi.org/10.1080/22423982.2022.2065755 https://doaj.org/article/8a11f535f4f54ba3984ce575eed8b5a6 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 81, Iss 1 (2022) |
op_relation |
https://www.tandfonline.com/doi/10.1080/22423982.2022.2065755 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2022.2065755 2242-3982 https://doaj.org/article/8a11f535f4f54ba3984ce575eed8b5a6 |
op_doi |
https://doi.org/10.1080/22423982.2022.2065755 |
container_title |
International Journal of Circumpolar Health |
container_volume |
81 |
container_issue |
1 |
_version_ |
1766340996165009408 |