Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil.
BACKGROUND:Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of e...
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ftdoajarticles:oai:doaj.org/article:89f8a712cc1142459d5ac6806f781119 2023-05-15T15:18:26+02:00 Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. Rita Medeiros Viviane Jusot Guy Houillon Anvar Rasuli Luzia Martorelli Ana Paula Kataoka Mohamed Ben Mechlia Anne-Sophie Le Guern Liliam Rodrigues Rhomero Assef Alvino Maestri Reynaldo Lima Yolande Rotivel Valérie Bosch-Castells Noël Tordo 2016-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004920 https://doaj.org/article/89f8a712cc1142459d5ac6806f781119 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5031405?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004920 https://doaj.org/article/89f8a712cc1142459d5ac6806f781119 PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004920 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004920 2022-12-31T01:42:03Z BACKGROUND:Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. METHODOLOGY/PRINCIPAL FINDINGS:This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers ≤0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0% of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9% of the interviewed population) had received at least one dose of booster since their vaccination in 2005. CONCLUSIONS/SIGNIFICANCE:This study and the events preceding it underscore ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Augusto ENVELOPE(-61.613,-61.613,-64.054,-64.054) Correa ENVELOPE(-61.500,-61.500,-64.400,-64.400) PLOS Neglected Tropical Diseases 10 9 e0004920 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rita Medeiros Viviane Jusot Guy Houillon Anvar Rasuli Luzia Martorelli Ana Paula Kataoka Mohamed Ben Mechlia Anne-Sophie Le Guern Liliam Rodrigues Rhomero Assef Alvino Maestri Reynaldo Lima Yolande Rotivel Valérie Bosch-Castells Noël Tordo Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. METHODOLOGY/PRINCIPAL FINDINGS:This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers ≤0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0% of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9% of the interviewed population) had received at least one dose of booster since their vaccination in 2005. CONCLUSIONS/SIGNIFICANCE:This study and the events preceding it underscore ... |
format |
Article in Journal/Newspaper |
author |
Rita Medeiros Viviane Jusot Guy Houillon Anvar Rasuli Luzia Martorelli Ana Paula Kataoka Mohamed Ben Mechlia Anne-Sophie Le Guern Liliam Rodrigues Rhomero Assef Alvino Maestri Reynaldo Lima Yolande Rotivel Valérie Bosch-Castells Noël Tordo |
author_facet |
Rita Medeiros Viviane Jusot Guy Houillon Anvar Rasuli Luzia Martorelli Ana Paula Kataoka Mohamed Ben Mechlia Anne-Sophie Le Guern Liliam Rodrigues Rhomero Assef Alvino Maestri Reynaldo Lima Yolande Rotivel Valérie Bosch-Castells Noël Tordo |
author_sort |
Rita Medeiros |
title |
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
title_short |
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
title_full |
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
title_fullStr |
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
title_full_unstemmed |
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil. |
title_sort |
persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004920 https://doaj.org/article/89f8a712cc1142459d5ac6806f781119 |
long_lat |
ENVELOPE(-61.613,-61.613,-64.054,-64.054) ENVELOPE(-61.500,-61.500,-64.400,-64.400) |
geographic |
Arctic Augusto Correa |
geographic_facet |
Arctic Augusto Correa |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004920 (2016) |
op_relation |
http://europepmc.org/articles/PMC5031405?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004920 https://doaj.org/article/89f8a712cc1142459d5ac6806f781119 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004920 |
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PLOS Neglected Tropical Diseases |
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10 |
container_issue |
9 |
container_start_page |
e0004920 |
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1766348636736716800 |