Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence
Abstract Several regions of the world frequently use the species Moringa oleifera Lam. (Moringaceae) in traditional medicine. This situation is even more common in African countries. Many literature reports point to the antimalarial potential of this species, indicating the efficacy of its chemical...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:89c215be31594624b4cef6f668099d55 2023-06-18T03:39:37+02:00 Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence José Jailson Lima Bezerra Anderson Angel Vieira Pinheiro Douglas Dourado 2023-05-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2022-0079 https://doaj.org/article/89c215be31594624b4cef6f668099d55 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100202&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2022-0079 https://doaj.org/article/89c215be31594624b4cef6f668099d55 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) Malaria Medicinal plants Flavonoids Plasmodium Antiplasmodial Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2023 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2022-0079 2023-06-04T00:39:26Z Abstract Several regions of the world frequently use the species Moringa oleifera Lam. (Moringaceae) in traditional medicine. This situation is even more common in African countries. Many literature reports point to the antimalarial potential of this species, indicating the efficacy of its chemical compounds against malaria-causing parasites of the genus Plasmodium. From this perspective, the present study reviews the ethnobotanical, pharmacological, toxicological, and phytochemical (flavonoids) evidence of M. oleifera, focusing on the treatment of malaria. Scientific articles were retrieved from Google Scholar, PubMed®, ScienceDirect®, and SciELO databases. Only articles published between 2002 and 2022 were selected. After applying the inclusion and exclusion criteria, this review used a total of 72 articles. These documents mention a large use of M. oleifera for the treatment of malaria in African and Asian countries. The leaves (63%) of this plant are the main parts used in the preparation of herbal medicines. The in vivo antimalarial activity of M. oleifera was confirmed through several studies using polar and nonpolar extracts, fractions obtained from the extracts, infusion, pellets, and oils obtained from this plant and tested in rodents infected by the following parasites of the genus Plasmodium: P. berghei, P. falciparum, P. yoelii, and P. chabaudi. Extracts obtained from M. oleifera showed no toxicity in preclinical tests. A total of 46 flavonoids were identified in the leaves and seeds of M. oleifera by different chromatography and mass spectrometry methods. Despite the scarcity of research on the antimalarial potential of compounds isolated from M. oleifera, the positive effects against malaria-causing parasites in previous studies are likely to correlate with the flavonoids that occur in this species. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 29 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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Malaria Medicinal plants Flavonoids Plasmodium Antiplasmodial Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
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Malaria Medicinal plants Flavonoids Plasmodium Antiplasmodial Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 José Jailson Lima Bezerra Anderson Angel Vieira Pinheiro Douglas Dourado Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
topic_facet |
Malaria Medicinal plants Flavonoids Plasmodium Antiplasmodial Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Several regions of the world frequently use the species Moringa oleifera Lam. (Moringaceae) in traditional medicine. This situation is even more common in African countries. Many literature reports point to the antimalarial potential of this species, indicating the efficacy of its chemical compounds against malaria-causing parasites of the genus Plasmodium. From this perspective, the present study reviews the ethnobotanical, pharmacological, toxicological, and phytochemical (flavonoids) evidence of M. oleifera, focusing on the treatment of malaria. Scientific articles were retrieved from Google Scholar, PubMed®, ScienceDirect®, and SciELO databases. Only articles published between 2002 and 2022 were selected. After applying the inclusion and exclusion criteria, this review used a total of 72 articles. These documents mention a large use of M. oleifera for the treatment of malaria in African and Asian countries. The leaves (63%) of this plant are the main parts used in the preparation of herbal medicines. The in vivo antimalarial activity of M. oleifera was confirmed through several studies using polar and nonpolar extracts, fractions obtained from the extracts, infusion, pellets, and oils obtained from this plant and tested in rodents infected by the following parasites of the genus Plasmodium: P. berghei, P. falciparum, P. yoelii, and P. chabaudi. Extracts obtained from M. oleifera showed no toxicity in preclinical tests. A total of 46 flavonoids were identified in the leaves and seeds of M. oleifera by different chromatography and mass spectrometry methods. Despite the scarcity of research on the antimalarial potential of compounds isolated from M. oleifera, the positive effects against malaria-causing parasites in previous studies are likely to correlate with the flavonoids that occur in this species. |
format |
Article in Journal/Newspaper |
author |
José Jailson Lima Bezerra Anderson Angel Vieira Pinheiro Douglas Dourado |
author_facet |
José Jailson Lima Bezerra Anderson Angel Vieira Pinheiro Douglas Dourado |
author_sort |
José Jailson Lima Bezerra |
title |
Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
title_short |
Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
title_full |
Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
title_fullStr |
Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
title_full_unstemmed |
Antimalarial potential of Moringa oleifera Lam. (Moringaceae): A review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
title_sort |
antimalarial potential of moringa oleifera lam. (moringaceae): a review of the ethnomedicinal, pharmacological, toxicological, and phytochemical evidence |
publisher |
SciELO |
publishDate |
2023 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2022-0079 https://doaj.org/article/89c215be31594624b4cef6f668099d55 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100202&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2022-0079 https://doaj.org/article/89c215be31594624b4cef6f668099d55 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2022-0079 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
29 |
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1769004336336076800 |