miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection

• Published in: Frontiers in Immunology
• Main Authors: Nardos Tesfaye Woldemariam, Oleg Agafonov, Hilde Sindre, Bjørn Høyheim, Ross D. Houston, Diego Robledo, James E. Bron, Rune Andreassen
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2020
• Subjects: Atlantic salmon; microRNA; IPNV; immune response; host-virus interactions; Immunologic diseases. Allergy; RC581-607; Ikka
• Online Access: https://doi.org/10.3389/fimmu.2020.02113; https://doaj.org/article/89b743077d0d4c4ea17ff2f05b5bde1e

Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host mi...