Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study.
Background A global stockpile of oral cholera vaccine (OCV) was established in 2013 for use in outbreak response and are licensed as two-dose regimens. Vaccine availability, however, remains limited. Previous studies have found that a single dose of OCV may provide substantial protection against cho...
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ftdoajarticles:oai:doaj.org/article:89a45d4783e540bcae193c2baa34f5c7 2023-05-15T15:12:19+02:00 Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. Tiffany Leung Julia Eaton Laura Matrajt 2022-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010358 https://doaj.org/article/89a45d4783e540bcae193c2baa34f5c7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010358 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010358 https://doaj.org/article/89a45d4783e540bcae193c2baa34f5c7 PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010358 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010358 2022-12-30T22:27:12Z Background A global stockpile of oral cholera vaccine (OCV) was established in 2013 for use in outbreak response and are licensed as two-dose regimens. Vaccine availability, however, remains limited. Previous studies have found that a single dose of OCV may provide substantial protection against cholera. Methods Using a mathematical model with two age groups paired with optimization algorithms, we determine the optimal vaccination strategy with one and two doses of vaccine to minimize cumulative overall infections, symptomatic infections, and deaths. We explore counterfactual vaccination scenarios in three distinct settings: Maela, the largest refugee camp in Thailand, with high in- and out-migration; N'Djamena, Chad, a densely populated region; and Haiti, where departments are connected by rivers and roads. Results Over the short term under limited vaccine supply, the optimal strategies for all objectives prioritize one dose to the older age group (over five years old), irrespective of setting and level of vaccination coverage. As more vaccine becomes available, it is optimal to administer a second dose for long-term protection. With enough vaccine to cover the whole population with one dose, the optimal strategies can avert up to 30% to 90% of deaths and 36% to 92% of symptomatic infections across the three settings over one year. The one-dose optimal strategies can avert 1.2 to 1.8 times as many cases and deaths compared to the standard two-dose strategy. Conclusions In an outbreak setting, speedy vaccination campaigns with a single dose of OCV is likely to avert more cases and deaths than a two-dose pro-rata campaign under a limited vaccine supply. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Rata ENVELOPE(19.216,19.216,69.928,69.928) PLOS Neglected Tropical Diseases 16 4 e0010358 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tiffany Leung Julia Eaton Laura Matrajt Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background A global stockpile of oral cholera vaccine (OCV) was established in 2013 for use in outbreak response and are licensed as two-dose regimens. Vaccine availability, however, remains limited. Previous studies have found that a single dose of OCV may provide substantial protection against cholera. Methods Using a mathematical model with two age groups paired with optimization algorithms, we determine the optimal vaccination strategy with one and two doses of vaccine to minimize cumulative overall infections, symptomatic infections, and deaths. We explore counterfactual vaccination scenarios in three distinct settings: Maela, the largest refugee camp in Thailand, with high in- and out-migration; N'Djamena, Chad, a densely populated region; and Haiti, where departments are connected by rivers and roads. Results Over the short term under limited vaccine supply, the optimal strategies for all objectives prioritize one dose to the older age group (over five years old), irrespective of setting and level of vaccination coverage. As more vaccine becomes available, it is optimal to administer a second dose for long-term protection. With enough vaccine to cover the whole population with one dose, the optimal strategies can avert up to 30% to 90% of deaths and 36% to 92% of symptomatic infections across the three settings over one year. The one-dose optimal strategies can avert 1.2 to 1.8 times as many cases and deaths compared to the standard two-dose strategy. Conclusions In an outbreak setting, speedy vaccination campaigns with a single dose of OCV is likely to avert more cases and deaths than a two-dose pro-rata campaign under a limited vaccine supply. |
format |
Article in Journal/Newspaper |
author |
Tiffany Leung Julia Eaton Laura Matrajt |
author_facet |
Tiffany Leung Julia Eaton Laura Matrajt |
author_sort |
Tiffany Leung |
title |
Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
title_short |
Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
title_full |
Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
title_fullStr |
Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
title_full_unstemmed |
Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study. |
title_sort |
optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: a modeling study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010358 https://doaj.org/article/89a45d4783e540bcae193c2baa34f5c7 |
long_lat |
ENVELOPE(19.216,19.216,69.928,69.928) |
geographic |
Arctic Rata |
geographic_facet |
Arctic Rata |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010358 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010358 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010358 https://doaj.org/article/89a45d4783e540bcae193c2baa34f5c7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010358 |
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PLOS Neglected Tropical Diseases |
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16 |
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4 |
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e0010358 |
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