The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission.
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body.Using notification data and clinical records review, we conducted a retrospective obs...
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ftdoajarticles:oai:doaj.org/article:89a3c0ba1f7b4084b21babc0933cc941 2023-05-15T15:11:52+02:00 The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. Arvind Yerramilli Ee Laine Tay Andrew J Stewardson Peter G Kelley Emma Bishop Grant A Jenkin Mike Starr Janine Trevillyan Andrew Hughes N Deborah Friedman Daniel P O'Brien Paul D R Johnson 2017-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005800 https://doaj.org/article/89a3c0ba1f7b4084b21babc0933cc941 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5584971?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005800 https://doaj.org/article/89a3c0ba1f7b4084b21babc0933cc941 PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005800 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005800 2022-12-31T13:04:06Z Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body.Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection.We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38-2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34-0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52-6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14-5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year.Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 8 e0005800 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Arvind Yerramilli Ee Laine Tay Andrew J Stewardson Peter G Kelley Emma Bishop Grant A Jenkin Mike Starr Janine Trevillyan Andrew Hughes N Deborah Friedman Daniel P O'Brien Paul D R Johnson The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body.Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection.We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38-2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34-0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52-6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14-5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year.Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission. |
format |
Article in Journal/Newspaper |
author |
Arvind Yerramilli Ee Laine Tay Andrew J Stewardson Peter G Kelley Emma Bishop Grant A Jenkin Mike Starr Janine Trevillyan Andrew Hughes N Deborah Friedman Daniel P O'Brien Paul D R Johnson |
author_facet |
Arvind Yerramilli Ee Laine Tay Andrew J Stewardson Peter G Kelley Emma Bishop Grant A Jenkin Mike Starr Janine Trevillyan Andrew Hughes N Deborah Friedman Daniel P O'Brien Paul D R Johnson |
author_sort |
Arvind Yerramilli |
title |
The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
title_short |
The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
title_full |
The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
title_fullStr |
The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
title_full_unstemmed |
The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission. |
title_sort |
location of australian buruli ulcer lesions-implications for unravelling disease transmission. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005800 https://doaj.org/article/89a3c0ba1f7b4084b21babc0933cc941 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005800 (2017) |
op_relation |
http://europepmc.org/articles/PMC5584971?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005800 https://doaj.org/article/89a3c0ba1f7b4084b21babc0933cc941 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005800 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
8 |
container_start_page |
e0005800 |
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1766342653667966976 |