Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon
Abstract Infectious salmon anaemia (ISA) virus (ISAV) is a fish orthomyxovirus that has recently been assigned to the new genus Isavirus within the family Orthomyxoviridae . It possesses the major functional characteristics of the virus family including haemagglutinating, receptor destroying enzyme...
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ftdoajarticles:oai:doaj.org/article:897edb68a43942a79b8fb1e0f3833744 2023-05-15T15:28:09+02:00 Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon Kibenge Molly JT Wright Glenda M Wadowska Dorota W Workenhe Samuel T Kibenge Frederick SB 2007-01-01T00:00:00Z https://doi.org/10.1186/1743-422X-4-13 https://doaj.org/article/897edb68a43942a79b8fb1e0f3833744 EN eng BMC http://www.virologyj.com/content/4/1/13 https://doaj.org/toc/1743-422X doi:10.1186/1743-422X-4-13 1743-422X https://doaj.org/article/897edb68a43942a79b8fb1e0f3833744 Virology Journal, Vol 4, Iss 1, p 13 (2007) Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1743-422X-4-13 2022-12-31T04:05:38Z Abstract Infectious salmon anaemia (ISA) virus (ISAV) is a fish orthomyxovirus that has recently been assigned to the new genus Isavirus within the family Orthomyxoviridae . It possesses the major functional characteristics of the virus family including haemagglutinating, receptor destroying enzyme (RDE), and fusion activities associated with the virion surface proteins. It is generally accepted that ISAV agglutinates erythrocytes of several fish species and that the ISAV RDE activity dissolves this haemagglutination reaction except for Atlantic salmon ( Salmo salar ) erythrocytes. We used electron microscopy to examine the physical interaction between ISAV and erythrocytes from Atlantic salmon and rainbow trout ( Oncorhynchus mykiss ) during haemagglutination. We present evidence that ISAV enters into Atlantic salmon erythrocytes. Atlantic salmon erythrocytes incubated with ISAV for 4 hours showed endocytosis of the virus particles, which is consistent with virus infection. These observations suggest that the lack of dissolution of ISAV-induced haemagglutination of Atlantic salmon erythrocytes favours virus infection of the erythrocytes. Moreover, such a haemagglutination-infection phenotype is fundamentally different from haemagglutination by avian and mammalian orthomyxoviruses, and is indicative of a different pathogenesis for the fish orthomyxovirus. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles Virology Journal 4 1 13 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Infectious and parasitic diseases RC109-216 |
spellingShingle |
Infectious and parasitic diseases RC109-216 Kibenge Molly JT Wright Glenda M Wadowska Dorota W Workenhe Samuel T Kibenge Frederick SB Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
topic_facet |
Infectious and parasitic diseases RC109-216 |
description |
Abstract Infectious salmon anaemia (ISA) virus (ISAV) is a fish orthomyxovirus that has recently been assigned to the new genus Isavirus within the family Orthomyxoviridae . It possesses the major functional characteristics of the virus family including haemagglutinating, receptor destroying enzyme (RDE), and fusion activities associated with the virion surface proteins. It is generally accepted that ISAV agglutinates erythrocytes of several fish species and that the ISAV RDE activity dissolves this haemagglutination reaction except for Atlantic salmon ( Salmo salar ) erythrocytes. We used electron microscopy to examine the physical interaction between ISAV and erythrocytes from Atlantic salmon and rainbow trout ( Oncorhynchus mykiss ) during haemagglutination. We present evidence that ISAV enters into Atlantic salmon erythrocytes. Atlantic salmon erythrocytes incubated with ISAV for 4 hours showed endocytosis of the virus particles, which is consistent with virus infection. These observations suggest that the lack of dissolution of ISAV-induced haemagglutination of Atlantic salmon erythrocytes favours virus infection of the erythrocytes. Moreover, such a haemagglutination-infection phenotype is fundamentally different from haemagglutination by avian and mammalian orthomyxoviruses, and is indicative of a different pathogenesis for the fish orthomyxovirus. |
format |
Article in Journal/Newspaper |
author |
Kibenge Molly JT Wright Glenda M Wadowska Dorota W Workenhe Samuel T Kibenge Frederick SB |
author_facet |
Kibenge Molly JT Wright Glenda M Wadowska Dorota W Workenhe Samuel T Kibenge Frederick SB |
author_sort |
Kibenge Molly JT |
title |
Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
title_short |
Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
title_full |
Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
title_fullStr |
Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
title_full_unstemmed |
Demonstration of infectious salmon anaemia virus (ISAV) endocytosis in erythrocytes of Atlantic salmon |
title_sort |
demonstration of infectious salmon anaemia virus (isav) endocytosis in erythrocytes of atlantic salmon |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1743-422X-4-13 https://doaj.org/article/897edb68a43942a79b8fb1e0f3833744 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Virology Journal, Vol 4, Iss 1, p 13 (2007) |
op_relation |
http://www.virologyj.com/content/4/1/13 https://doaj.org/toc/1743-422X doi:10.1186/1743-422X-4-13 1743-422X https://doaj.org/article/897edb68a43942a79b8fb1e0f3833744 |
op_doi |
https://doi.org/10.1186/1743-422X-4-13 |
container_title |
Virology Journal |
container_volume |
4 |
container_issue |
1 |
container_start_page |
13 |
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1766358539418206208 |