Patterns of anti-malarial drug treatment among pregnant women in Uganda
Abstract Background Prompt use of an effective anti-malarial drug is essential for controlling malaria and its adverse effects in pregnancy. The World Health Organization recommends an artemisinin-based combination therapy as the first-line treatment of uncomplicated malaria in the second and third...
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ftdoajarticles:oai:doaj.org/article:896005143bea4b11b9d896aa6611edd2 2023-05-15T15:12:48+02:00 Patterns of anti-malarial drug treatment among pregnant women in Uganda Staedke Sarah G Richardson Barbra A Brentlinger Paula E Weiss Noel S Sangaré Laura R Kiwuwa Mpungu S Stergachis Andy 2011-06-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-152 https://doaj.org/article/896005143bea4b11b9d896aa6611edd2 EN eng BMC http://www.malariajournal.com/content/10/1/152 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-152 1475-2875 https://doaj.org/article/896005143bea4b11b9d896aa6611edd2 Malaria Journal, Vol 10, Iss 1, p 152 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-152 2022-12-31T08:54:40Z Abstract Background Prompt use of an effective anti-malarial drug is essential for controlling malaria and its adverse effects in pregnancy. The World Health Organization recommends an artemisinin-based combination therapy as the first-line treatment of uncomplicated malaria in the second and third trimesters of pregnancy. The study objective was to determine the degree to which presumed episodes of uncomplicated symptomatic malaria in pregnancy were treated with a recommended anti-malarial regimen in a region of Uganda. Methods Utilizing a population-based random sample, we interviewed women living in Jinja, Uganda who had been pregnant in the past year. Results Self-reported malaria during the index pregnancy was reported among 67% (n = 334) of the 500 participants. Among the 637 self-reported episodes of malaria, an anti-malarial drug was used for treatment in 85% of the episodes. Use of a currently recommended treatment in the first trimester was uncommon (5.6%). A contraindicated anti-malarial drug (sulphadoxine-pyrimethamine and/or artemether-lumefantrine) was involved in 70% of first trimester episodes. Recommended anti-malarials were used according to the guidelines in only 30.1% of all second and third trimester episodes. Conclusions Self-reported malaria was extremely common in this population and adherence to treatment guidelines for the management of malaria in pregnancy was poor. Use of artemether-lumefantrine combined with non-recommended anti-malarials was common practice. Overuse of anti-malarial drugs, especially ones that are no longer recommended, undermines malaria control efforts by fueling the spread of drug resistance and delaying appropriate treatment of non-malarial febrile illnesses. Improved diagnostic capacity is essential to ultimately improving the management of malaria-like symptoms during pregnancy and appropriate use of currently available anti-malarials. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Staedke Sarah G Richardson Barbra A Brentlinger Paula E Weiss Noel S Sangaré Laura R Kiwuwa Mpungu S Stergachis Andy Patterns of anti-malarial drug treatment among pregnant women in Uganda |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Prompt use of an effective anti-malarial drug is essential for controlling malaria and its adverse effects in pregnancy. The World Health Organization recommends an artemisinin-based combination therapy as the first-line treatment of uncomplicated malaria in the second and third trimesters of pregnancy. The study objective was to determine the degree to which presumed episodes of uncomplicated symptomatic malaria in pregnancy were treated with a recommended anti-malarial regimen in a region of Uganda. Methods Utilizing a population-based random sample, we interviewed women living in Jinja, Uganda who had been pregnant in the past year. Results Self-reported malaria during the index pregnancy was reported among 67% (n = 334) of the 500 participants. Among the 637 self-reported episodes of malaria, an anti-malarial drug was used for treatment in 85% of the episodes. Use of a currently recommended treatment in the first trimester was uncommon (5.6%). A contraindicated anti-malarial drug (sulphadoxine-pyrimethamine and/or artemether-lumefantrine) was involved in 70% of first trimester episodes. Recommended anti-malarials were used according to the guidelines in only 30.1% of all second and third trimester episodes. Conclusions Self-reported malaria was extremely common in this population and adherence to treatment guidelines for the management of malaria in pregnancy was poor. Use of artemether-lumefantrine combined with non-recommended anti-malarials was common practice. Overuse of anti-malarial drugs, especially ones that are no longer recommended, undermines malaria control efforts by fueling the spread of drug resistance and delaying appropriate treatment of non-malarial febrile illnesses. Improved diagnostic capacity is essential to ultimately improving the management of malaria-like symptoms during pregnancy and appropriate use of currently available anti-malarials. |
format |
Article in Journal/Newspaper |
author |
Staedke Sarah G Richardson Barbra A Brentlinger Paula E Weiss Noel S Sangaré Laura R Kiwuwa Mpungu S Stergachis Andy |
author_facet |
Staedke Sarah G Richardson Barbra A Brentlinger Paula E Weiss Noel S Sangaré Laura R Kiwuwa Mpungu S Stergachis Andy |
author_sort |
Staedke Sarah G |
title |
Patterns of anti-malarial drug treatment among pregnant women in Uganda |
title_short |
Patterns of anti-malarial drug treatment among pregnant women in Uganda |
title_full |
Patterns of anti-malarial drug treatment among pregnant women in Uganda |
title_fullStr |
Patterns of anti-malarial drug treatment among pregnant women in Uganda |
title_full_unstemmed |
Patterns of anti-malarial drug treatment among pregnant women in Uganda |
title_sort |
patterns of anti-malarial drug treatment among pregnant women in uganda |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-152 https://doaj.org/article/896005143bea4b11b9d896aa6611edd2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 152 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/152 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-152 1475-2875 https://doaj.org/article/896005143bea4b11b9d896aa6611edd2 |
op_doi |
https://doi.org/10.1186/1475-2875-10-152 |
container_title |
Malaria Journal |
container_volume |
10 |
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1 |
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1766343446646226944 |