Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana.
Background As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, integrated serologica...
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ftdoajarticles:oai:doaj.org/article:895af05547b047f69b13744c11be7836 2023-05-15T15:08:37+02:00 Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan 2022-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010227 https://doaj.org/article/895af05547b047f69b13744c11be7836 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010227 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010227 https://doaj.org/article/895af05547b047f69b13744c11be7836 PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010227 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010227 2022-12-30T21:41:39Z Background As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, integrated serological surveys enable simultaneous characterisation of residual transmission of multiple pathogens. Methodology/principal findings Here, we combine integrated serological surveys with geostatistical modelling and remote sensing-derived environmental data to estimate the spatial distribution of exposure to multiple diseases in children in Northern Ghana. The study utilised the trachoma surveillance survey platform (cross-sectional two-stage cluster-sampled surveys) to collect information on additional identified diseases at different stages of elimination with minimal additional cost. Geostatistical modelling of serological data allowed identification of areas with high probabilities of recent exposure to diseases of interest, including areas previously unknown to control programmes. We additionally demonstrate how serological surveys can be used to identify areas with exposure to multiple diseases and to prioritise areas with high uncertainty for future surveys. Modelled estimates of cluster-level prevalence were strongly correlated with more operationally feasible metrics of antibody responses. Conclusions/significance This study demonstrates the potential of integrated serological surveillance to characterise spatial distributions of exposure to multiple pathogens in low transmission and elimination settings when the probability of detecting infections is low. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 3 e0010227 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, integrated serological surveys enable simultaneous characterisation of residual transmission of multiple pathogens. Methodology/principal findings Here, we combine integrated serological surveys with geostatistical modelling and remote sensing-derived environmental data to estimate the spatial distribution of exposure to multiple diseases in children in Northern Ghana. The study utilised the trachoma surveillance survey platform (cross-sectional two-stage cluster-sampled surveys) to collect information on additional identified diseases at different stages of elimination with minimal additional cost. Geostatistical modelling of serological data allowed identification of areas with high probabilities of recent exposure to diseases of interest, including areas previously unknown to control programmes. We additionally demonstrate how serological surveys can be used to identify areas with exposure to multiple diseases and to prioritise areas with high uncertainty for future surveys. Modelled estimates of cluster-level prevalence were strongly correlated with more operationally feasible metrics of antibody responses. Conclusions/significance This study demonstrates the potential of integrated serological surveillance to characterise spatial distributions of exposure to multiple pathogens in low transmission and elimination settings when the probability of detecting infections is low. |
format |
Article in Journal/Newspaper |
author |
Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan |
author_facet |
Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan |
author_sort |
Kimberly M Fornace |
title |
Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
title_short |
Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
title_full |
Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
title_fullStr |
Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
title_full_unstemmed |
Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
title_sort |
characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in northern ghana. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010227 https://doaj.org/article/895af05547b047f69b13744c11be7836 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010227 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010227 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010227 https://doaj.org/article/895af05547b047f69b13744c11be7836 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010227 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
3 |
container_start_page |
e0010227 |
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1766339944426504192 |