Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos
Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-p...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2018
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Online Access: | https://doi.org/10.4103/2221-1691.245971 https://doaj.org/article/88fb5b2f6a0e45dc95ca14ea332deab5 |
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ftdoajarticles:oai:doaj.org/article:88fb5b2f6a0e45dc95ca14ea332deab5 2023-05-15T15:10:43+02:00 Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos Zalilawati Mat Rashid Abdul M Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.245971 https://doaj.org/article/88fb5b2f6a0e45dc95ca14ea332deab5 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=11;spage=554;epage=564;aulast=Rashid https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.245971 https://doaj.org/article/88fb5b2f6a0e45dc95ca14ea332deab5 Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 11, Pp 554-564 (2018) aaptos aaptos fatty acid p-hydroxybenzamide antioxidant cytotoxicity antivirus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.245971 2022-12-31T01:23:21Z Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 11 554 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
aaptos aaptos fatty acid p-hydroxybenzamide antioxidant cytotoxicity antivirus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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aaptos aaptos fatty acid p-hydroxybenzamide antioxidant cytotoxicity antivirus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Zalilawati Mat Rashid Abdul M Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
topic_facet |
aaptos aaptos fatty acid p-hydroxybenzamide antioxidant cytotoxicity antivirus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process. |
format |
Article in Journal/Newspaper |
author |
Zalilawati Mat Rashid Abdul M Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad |
author_facet |
Zalilawati Mat Rashid Abdul M Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad |
author_sort |
Zalilawati Mat Rashid |
title |
Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
title_short |
Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
title_full |
Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
title_fullStr |
Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
title_full_unstemmed |
Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos |
title_sort |
phenolics, fatty acids composition and biological activities of various extracts and fractions of malaysian aaptos aaptos |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.245971 https://doaj.org/article/88fb5b2f6a0e45dc95ca14ea332deab5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 11, Pp 554-564 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=11;spage=554;epage=564;aulast=Rashid https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.245971 https://doaj.org/article/88fb5b2f6a0e45dc95ca14ea332deab5 |
op_doi |
https://doi.org/10.4103/2221-1691.245971 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
8 |
container_issue |
11 |
container_start_page |
554 |
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1766341685064761344 |