Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis
Four cases of severe pulmonary form of leptospirosis (SPFL) are described. In all four of these blood culture proven cases, there was severe pulmonary injury characterized by alveolar hemorrhage and acute respiratory failure. Three patients died in less than 48 hours after onset of the first respira...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:88a6f13afabe428b88848296febbe636 2023-05-15T15:03:12+02:00 Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis João José Pereira da Silva Marcos Olivier Dalston Jorge Eduardo Manhães de Carvalho Sérgio Setúbal Janice Mery Chiarino de Oliveira Martha Maria Pereira 2002-08-01T00:00:00Z https://doaj.org/article/88a6f13afabe428b88848296febbe636 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000400017&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/88a6f13afabe428b88848296febbe636 Revista da Sociedade Brasileira de Medicina Tropical, Vol 35, Iss 4, Pp 395-399 (2002) Leptospirosis Weil's disease Pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 article 2002 ftdoajarticles 2022-12-30T23:24:23Z Four cases of severe pulmonary form of leptospirosis (SPFL) are described. In all four of these blood culture proven cases, there was severe pulmonary injury characterized by alveolar hemorrhage and acute respiratory failure. Three patients died in less than 48 hours after onset of the first respiratory signs. Leptospiral antigen detection in lung tissues was positive by immunoperoxidase in all three of these cases, suggesting that the microorganism exerts a local direct destructive action. Patients with SPFL should be carefully monitored, as the abrupt onset of severe alveolar hemorrhage can lead to respiratory insufficiency and death. The authors emphasize the importance of radiological findings and blood gas analysis for prompt clinical diagnosis, and suggest that corticosteroids, associated with antibiotics, early respiratory support, and platelet transfusions are useful as an attempt to prevent further development of SPFL. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leptospirosis Weil's disease Pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Leptospirosis Weil's disease Pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 João José Pereira da Silva Marcos Olivier Dalston Jorge Eduardo Manhães de Carvalho Sérgio Setúbal Janice Mery Chiarino de Oliveira Martha Maria Pereira Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
topic_facet |
Leptospirosis Weil's disease Pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 |
description |
Four cases of severe pulmonary form of leptospirosis (SPFL) are described. In all four of these blood culture proven cases, there was severe pulmonary injury characterized by alveolar hemorrhage and acute respiratory failure. Three patients died in less than 48 hours after onset of the first respiratory signs. Leptospiral antigen detection in lung tissues was positive by immunoperoxidase in all three of these cases, suggesting that the microorganism exerts a local direct destructive action. Patients with SPFL should be carefully monitored, as the abrupt onset of severe alveolar hemorrhage can lead to respiratory insufficiency and death. The authors emphasize the importance of radiological findings and blood gas analysis for prompt clinical diagnosis, and suggest that corticosteroids, associated with antibiotics, early respiratory support, and platelet transfusions are useful as an attempt to prevent further development of SPFL. |
format |
Article in Journal/Newspaper |
author |
João José Pereira da Silva Marcos Olivier Dalston Jorge Eduardo Manhães de Carvalho Sérgio Setúbal Janice Mery Chiarino de Oliveira Martha Maria Pereira |
author_facet |
João José Pereira da Silva Marcos Olivier Dalston Jorge Eduardo Manhães de Carvalho Sérgio Setúbal Janice Mery Chiarino de Oliveira Martha Maria Pereira |
author_sort |
João José Pereira da Silva |
title |
Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
title_short |
Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
title_full |
Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
title_fullStr |
Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
title_full_unstemmed |
Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
title_sort |
clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2002 |
url |
https://doaj.org/article/88a6f13afabe428b88848296febbe636 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 35, Iss 4, Pp 395-399 (2002) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000400017&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/88a6f13afabe428b88848296febbe636 |
_version_ |
1766335085333708800 |